公开(公告)号：EP1939209A1

公开(公告)日：2008-07-02

申请号：EP06796921.2

申请日：2006-08-29

申请人： Eisai R&D Management Co., Ltd.

发明人： TAGAMI, Katsuya ,  SATO, Keizo ,  MATSUO, Kimihiro ,  ABE, Taichi ,  HAGA, Toyokazu

IPC分类号： C07H15/12

CPC分类号： C07H15/04 ,  C07H1/02

摘要： Discloses is a process for producing α-D-glucopyranose, 3-O-decyl-2-deoxy-6-O-[2-deoxy-3-O-[(3R)-3-methoxydecyl]-6-O-methyl-2-[(11Z)-1-oxo-11-octadecenyl]amino]-4-O-phosphono-β-D-glucopyranosyl]-2-[(1,3-dioxotetradecyl)amino]- or 1-(dihydrogen phosphate) tetrasodium salt which is useful as an active ingredient of a pharmaceutical or an intermediate for the synthesis thereof, which is environment-friendly and excellent in safety, operationality and reproducibility. A process for producing a compound represented by the formula (I) comprising the steps of reacting a compound represented by the formula (VIII) with a palladium catalyst in the presence of a nucleopholic agent and treating the product with a sodium source.

摘要翻译： 公开了一种生产±-D-吡喃葡萄糖，3-O-癸基-2-脱氧-6-O- [2-脱氧-3-O - [（3R）-3-甲氧基癸基] -6-O-甲基 -2 - [（11Z）-1-氧代-11-十八碳烯基]氨基] -4-O-膦酰基-2-D-吡喃葡萄糖基] -2 - [（1,3-二氧代十四烷基）氨基] - 或1-（二氢 磷酸盐）四钠盐，其可用作其合成的药物或中间体的活性成分，其环境友好并且安全性，可操作性和再现性优异。 一种制备由式（I）表示的化合物的方法，包括以下步骤：使式（VIII）表示的化合物与钯催化剂在一种核仁制剂存在下反应并用钠源处理该产物。

公开(公告)号：EP2096116B1

公开(公告)日：2012-08-15

申请号：EP07832309.4

申请日：2007-11-21

申请人： Eisai R&D Management Co., Ltd.

发明人： SAKURAI, Shin ,  FURUKAWA, Ken ,  MATSUO, Kimihiro ,  TAGAMI, Kenichi

IPC分类号： C07H15/12 ,  A61K47/26

CPC分类号： C07H15/12

摘要： Disclosed are a sodium salt represented by the average formula (I) below, and a method for producing such a sodium salt. (In the formula, m1, n1, m2 and n2 independently represent 0 or a positive number not more than 2, while satisfying m1 + n1 =2, m2 + n2 =2, 0

公开(公告)号：EP2096116A1

公开(公告)日：2009-09-02

申请号：EP07832309.4

申请日：2007-11-21

申请人： Eisai R&D Management Co., Ltd.

发明人： SAKURAI, Shin ,  FURUKAWA, Ken ,  MATSUO, Kimihiro ,  TAGAMI, Kenichi

IPC分类号： C07H15/12 ,  A61K47/26

CPC分类号： C07H15/12

摘要： Abstract: Disclosed are a sodium salt represented by the average formula (I) below, and a method for producing such a sodium salt. (In the formula, m 1 , n 1 m 2 and n 2 independently represent 0 or a positive number not greater than 2, while satisfying m 1 + n 1 = 2, m 2 + n 2 = 2, 0 1 + m 2 1 + n 2

摘要翻译： 摘要：公开了由下述平均式（I）表示的钠盐及其制备方法。 （式中，m 1，n 1 m 2，n 2独立地表示0或不大于2的正数，而满足m 1 + n 1 = 2，m 2 + n 2 = 2,0