-
1.发明公开SUBSTITUTED PHENYLALANINE TYPE COMPOUNDS WHICH INHIBIT LEUKOCYTE ADHESION MEDIATED BY VLA-4 失效取代的苯丙氨酸衍生物，血液白细胞抑制其VLA-4介导的粘附
公开(公告)号：EP1001972A1
公开(公告)日：2000-05-24
申请号：EP98937990.4
申请日：1998-07-30
发明人： THORSETT, Eugene, D. , SEMKO, Christopher, M. , SARANTAKIS, Dimitrios , PLEISS, Michael, A. , LOMBARDO, Louis, John , KREFT, Anthony , KONRADI, Andrei, W. , GRANT, Francine, S. , DRESSEN, Darren, B. , DAPPEN, Michael, S. , BAUDY, Reinhardt, Bernhard , ASHWELL, Susan
CPC分类号： C07K5/06139 , A61K38/00 , C07K5/06026 , C07K5/0606 , C07K5/06078 , C07K5/06165
摘要： Disclosed are compounds which bind VLA-4. Certain of these compounds also inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by VLA-4. Such compounds are useful in the treatment of inflammatory diseases in a mammalian patient, e.g., human, such as asthma, Alzheimer's disease, atherosclerosis, AIDS dementia, diabetes, inflammatory bowel disease, rheumatoid arthritis, tissue transplantation, tumor metastasis and myocardial ischemia. The compounds are also be administered for the treatment of inflammatory brain diseases such as multiple sclerosis.
-
2.发明公开
公开(公告)号：EP0994895A1
公开(公告)日：2000-04-26
申请号：EP98937991.2
申请日：1998-07-30
发明人： THORSETT, Eugene, D. , SEMKO, Christopher, M. , PLEISS, Michael, A. , KONRADI, Andrei, W. , GRANT, Francine, S. , DRESSEN, Darren, B. , BAUDY, Reinhardt, Bernhard
CPC分类号： C07K5/06026 , A61K38/00 , C07K5/06078 , C07K5/06165
摘要： Diclosed are compounds which bind VLA-4. Certain of these compounds also inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by VLA-4. Such compounds are useful in the treatment of inflammatory diseases in a mammalian patient, e.g., human, such as asthma, Alzheimer's disease, atherosclerosis, AIDS dementia, diabetes, inflammatory bowel disease, rheumatoid arthristis, tissue transplantation, tumor metastasis and myocardial ischemia. The compounds can also be administered for the treatment of inflammatory brain diseases such as multiple sclerosis.
-
3.发明公开ACYL DERIVATIVES WHICH TREAT VLA-4 RELATED DISORDERS 有权ACYL DORIVATE ZUR BEHANDLUNG VON KRANKHEITEN DIE在ZUSAMMENHANG MIT VLA-4 STEHEN
公开(公告)号：EP1144388A1
公开(公告)日：2001-10-17
申请号：EP00913245.7
申请日：2000-01-21
发明人： KONRADI, Andrei , PLEISS, Michael, A. , THORSETT, Eugene, D. , ASHWELL, Susan , WELMAKER, Gregory, S. , KREFT, Anthony , SARANTAKIS, Dimitrios , DRESSEN, Darren, B. , GRANT, Francine, S. , SEMKO, Christopher , XU, Ying-Zi
IPC分类号： C07D239/42 , A61K31/505 , A61P7/00 , C07D401/12 , A61K31/495 , C07D405/12 , C07D409/12 , C07D285/10 , A61K31/41 , C07D417/12
CPC分类号： A61K31/425 , A61K31/41 , A61K31/427 , A61K31/433 , A61K31/44 , A61K31/4439 , A61K31/445 , A61K31/495 , A61K31/496 , A61K31/4965 , A61K31/497 , A61K31/50 , A61K31/505 , A61K31/506 , A61K31/53 , A61K31/535 , A61K31/54 , C07D211/58 , C07D213/74 , C07D213/76 , C07D233/88 , C07D239/32 , C07D239/42 , C07D239/47 , C07D239/48 , C07D239/52 , C07D241/20 , C07D249/06 , C07D251/18 , C07D251/48 , C07D251/50 , C07D251/52 , C07D251/54 , C07D257/06 , C07D285/06 , C07D285/10 , C07D333/36 , C07D333/48 , C07D401/04 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/04 , C07D413/12 , C07D417/12 , Y02A50/463 , A61K2300/00
摘要： Disclosed are compounds which bind VLA-4. Certain of these compounds also inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by VLA-4. Such compounds are useful in the treatment of inflammatory diseases in a mammalian patient, e.g., human, such as asthma, Alzheimer's disease, atherosclerosis, AIDS dementia, diabetes, inflammatory bowel disease, rheumatoid arthritis, tissue transplantation, tumor metastasis and myocardial ischemia. The compounds can also be administered for the treatment of inflammatory brain diseases such as multiple sclerosis.
摘要翻译： 公开了结合VLA-4的化合物。 这些化合物中的某些也抑制白细胞粘附，特别是由VLA-4介导的白细胞粘附。 这样的化合物可用于治疗哺乳动物患者例如人类例如哮喘，阿尔茨海默氏病，动脉粥样硬化，艾滋病痴呆，糖尿病，炎性肠病，类风湿性关节炎，组织移植，肿瘤转移和心肌缺血等炎性疾病。 化合物也可以用于治疗炎性脑疾病如多发性硬化症。
-
4.发明公开COMPOUNDS WHICH INHIBIT LEUKOCYTE ADHESION MEDIATED BY VLA-4 有权VERBINDUNGEN DIE DIE VLA-4 VERMITTELTEADHÄSIONVON LEUKOZYTEN INHIBIEREN
公开(公告)号：EP1144384A1
公开(公告)日：2001-10-17
申请号：EP00904487.6
申请日：2000-01-21
发明人： KONRADI, Andrei, W. , PLEISS, Michael, A. , THORSETT, Eugene, D. , ASHWELL, Susan , SARANTAKIS, Dimitrios , WELMAKER, Gregory, S. , KREFT, Anthony , SEMKO, Christopher , SULLIVAN, Robert, Warren , SOARES, Christopher, Joseph , LY, Kiev, Sui , TARBY, Christine, M.
IPC分类号： C07D233/66 , A61K31/38 , C07D257/06 , A61K31/41 , C07D231/38 , C07D249/06 , C07D233/88 , A61K31/415 , C07D401/04 , A61K31/44 , C07D213/74 , A61K31/53 , C07D403/12 , C07D239/48 , A61K31/505
CPC分类号： A61K31/425 , A61K31/41 , A61K31/427 , A61K31/433 , A61K31/44 , A61K31/4439 , A61K31/445 , A61K31/495 , A61K31/496 , A61K31/4965 , A61K31/497 , A61K31/50 , A61K31/505 , A61K31/506 , A61K31/53 , A61K31/535 , A61K31/54 , C07D211/58 , C07D213/74 , C07D213/76 , C07D233/88 , C07D239/32 , C07D239/42 , C07D239/47 , C07D239/48 , C07D239/52 , C07D241/20 , C07D249/06 , C07D251/18 , C07D251/48 , C07D251/50 , C07D251/52 , C07D251/54 , C07D257/06 , C07D285/06 , C07D285/10 , C07D333/36 , C07D333/48 , C07D401/04 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/04 , C07D413/12 , C07D417/12 , Y02A50/463 , A61K2300/00
摘要： Disclosed are compounds which bind VLA-4. Certain of these compounds also inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by VLA-4. Such compounds are useful in the treatment of inflammatory diseases in a mammalian patient, e.g., human, such as asthma, Alzheimer's disease, atherosclerosis, AIDS dementia, diabetes, inflammatory bowel disease, rheumatoid arthritis, tissue transplantation, tumor metastasis and myocardial ischemia. The compounds can also be administered for the treatment of inflammatory brain diseases such as multiple sclerosis.
摘要翻译： 公开了结合VLA-4的化合物。 这些化合物中的某些也抑制白细胞粘附，特别是由VLA-4介导的白细胞粘附。 这样的化合物可用于治疗哺乳动物患者例如人类例如哮喘，阿尔茨海默氏病，动脉粥样硬化，艾滋病痴呆，糖尿病，炎性肠病，类风湿性关节炎，组织移植，肿瘤转移和心肌缺血等炎性疾病。 化合物也可以用于治疗炎性脑疾病如多发性硬化症。
-
5.发明公开4-AMINO-PHENYLALANINE TYPE COMPOUNDS WHICH INHIBIT LEUKOCYTE ADHESION MEDIATED BY VLA-4 失效WITH A 4-氨基苯丙氨酸LINKS，血液白细胞抑制其VLA-4介导的粘附
公开(公告)号：EP1001974A1
公开(公告)日：2000-05-24
申请号：EP98937049.9
申请日：1998-07-30
发明人： ASHWELL, Susan , GRANT, Francine, S. , KONRADI, Andrei, W. , KREFT, Anthony , LOMBARDO, Louis, John , PLEISS, Michael, A. , SARANTAKIS, Dimitrios , SEMKO, Christopher, M. , THORSETT, Eugene, D.
CPC分类号： C07K5/06139 , A61K38/00 , C07K5/06026 , C07K5/0606 , C07K5/06078 , C07K5/06165
摘要： Disclosed are compounds which bind VLA-4. Certain of these compounds also inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by VLA-4. Such compounds are useful in the treatment of inflammatory diseases in a mammalian patient, e.g, human, such as asthma, Alzheimer's disease, atherosclerosis, AIDS dementia, diabetes, inflammatory bowel disease, rheumatoid arthritis, tissue transplantation, tumor metastasis and myocardial ischemia. The compounds can also be administered for the treatment of inflammatory brain diseases such as multiple sclerosis.
-
6.发明公开CARBAMYLOXY COMPOUNDS WHICH INHIBIT LEUKOCYTE ADHESION MEDIATED BY VLA-4 失效氨基甲酰氧基化合物，用来抑制VLA-4介导的白细胞
公开(公告)号：EP1000051A1
公开(公告)日：2000-05-17
申请号：EP98937052.3
申请日：1998-07-31
发明人： THORSETT, Eugene, D. , SEMKO, Christopher, M. , SARANTAKIS, Dimitrios , PLEISS, Michael, A. , KREFT, Anthony , KONRADI, Andrei, W. , GRANT, Francine, S. , DRESSEN, Darren, B. , ASHWELL, Susan , BAUDY, Reinhardt, Bernhard , LOMBARDO, Louis, John
IPC分类号： C07D311/18 , C07D207/48 , C07D277/56 , C07D279/12 , C07D277/06 , C07D403/12 , A61K31/18 , A61K31/415 , A61K31/425 , A61K31/54 , A61K31/495
CPC分类号： C07K5/06026 , A61K38/00 , C07K5/0215 , C07K5/06139 , C07K5/06165
摘要： Disclosed are compounds which bind VLA-4. Certain of these compounds also inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by VLA-4. Such compounds are useful in the treatment of inflammatory diseases in a mammalian patient, e.g., human, such as asthma, Alzheimer's disease, atherosclerosis, AIDS dementia, diabetes, inflammatory bowel disease, rheumatoid arthritis, tissue transplantation, tumor metastasis and myocardial ischemia. The compounds can also be administered for the treatment of inflammatory brain diseases such as multiple sclerosis.
-
7.发明公开PYROGLUTAMIC ACID DERIVATIVES AND RELATED COMPOUNDS WHICH INHIBIT LEUKOCYTE ADHESION MEDIATED BY VLA-4 有权PYROGLUTAMINSÄUREDERIVATE和相关化合物，通过VLA-4介导的白细胞粘附REDUCE
公开(公告)号：EP1144435A2
公开(公告)日：2001-10-17
申请号：EP00904486.8
申请日：2000-01-21
发明人： DRESSEN, Darren, B. , KREFT, Anthony , KUBRAK, Dennis , MANN, Charles, William , PLEISS, Michael, A. , STACK, Gary, Paul , THORSETT, Eugene, D.
IPC分类号： C07K5/00
CPC分类号： C07K5/06173 , C07K5/06139 , C07K5/06165 , C07K5/06191
摘要： Disclosed are pyroglutamic acid derivatives and related compounds which bind VLA-4. Certain of these compounds also inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by VLA-4. Such compounds are useful in the treatment of inflammatory diseases in a mammalian patient, e.g., human, such as asthma, Alzheimer's disease, atherosclerosis, AIDS dementia, diabetes, inflammatory bowel disease, rheumatoid arthritis, tissue transplantation, tumor metastasis and myocardial ischemia. The compounds can also be administered for the treatment of inflammatory brain diseases such as multiple sclerosis.
-
8.发明公开BENZYL COMPOUNDS WHICH INHIBIT LEUKOCYTE ADHESION MEDIATED BY VLA-4 失效苄THAT INHIBIT血液白细胞的VLA-4-介导的粘附
公开(公告)号：EP1001975A1
公开(公告)日：2000-05-24
申请号：EP98937054.9
申请日：1998-07-31
发明人： THORSETT, Eugene, D. , SEMKO, Christopher, M. , PLEISS, Michael, A. , LOMBARDO, Louis, John , KONRADI, Andrei, W. , GRANT, Francine, S. , DRESSEN, Darren, B. , DAPPEN, Michael, S.
IPC分类号： C07K5/078 , C07D207/16 , A61K38/05 , A61K31/40
CPC分类号： C07K5/06165 , C07K5/06139
摘要： Disclosed are compounds which bind VLA-4. Certain of these compounds also inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by VLA-4. Such compounds are useful in the treatment of inflammatory diseases in a mammalian patient, e.g., human, wherein the disease may be, for example, asthma, Alzheimer's disease, atherosclerosis, AIDS dementia, diabetes, inflammatory bowel disease, rheumatoid arthritis, tissue transplantation, tumor metastasis and myocardial ischemia. The coumpounds can also be administered for the treatment of inflammatory brain diseases such as multiple sclerosis.
-
公开(公告)号：EP1001973A1
公开(公告)日：2000-05-24
申请号：EP98938207.2
申请日：1998-07-31
发明人： DAPPEN, Michael, S. , DRESSEN, Darren, B. , GRANT, Francine, S. , PLEISS, Michael, A. , ROBINSON, Cynthia, Y. , SARANTAKIS, Dimitrios , THORSETT, Eugene, D.
CPC分类号： C07K5/0606 , A61K38/00 , C07K5/06026 , C07K5/06078 , C07K5/06113 , C07K5/06139
摘要： Disclosed are compounds which bind VLA-4. Certain of these compounds also inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by VLA-4. Such compounds are useful in the treatment of inflammatory diseases in a mammalian patient, e.g., human, such as asthma, Alzheimer's disease, atherosclerosis, AIDS dementia, diabetes, inflammatory bowel disease, rheumatoid arthritis, tissue transplantation, tumor metastasis and myocardial ischemia. The compounds can also be administered for the treatment of inflammatory brain diseases such as multiple sclerosis.
-
10.发明公开DIPEPTIDE AND RELATED COMPOUNDS WHICH INHIBIT LEUKOCYTE ADHESION MEDIATED BY VLA-4 失效二肽和相关化合物，血液白细胞抑制其VLA-4介导的粘附
公开(公告)号：EP1001971A1
公开(公告)日：2000-05-24
申请号：EP98937053.1
申请日：1998-07-31
发明人： THORSETT, Eugene, D. , SEMKO, Christopher, M. , PLEISS, Michael, A. , LOMBARDO, Louis, John , GRANT, Francine, S. , DRESSEN, Darren, B. , DAPPEN, Michael, S.
CPC分类号： C07K5/06026 , A61K38/00 , C07K5/06104 , C07K5/06139 , C07K5/06165
摘要： Disclosed are compounds which bind VLA-4. Certain of these compounds also inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by VLA-4. Such compounds are useful in the treatment of inflammatory diseases in a mammalian patient, e.g., human, such as asthma, Alzheimer's disease, atherosclerosis, AIDS dementia, diabetes, inflammatory bowel disease, rheumatoid arthritis, tissue transplantation, tumor metastasis and myocardial ischemia. The compounds can also be administered for the treatment of inflammatory brains diseases such as multiple sclerosis.
-
-
-
-
-
-
-
-
-
搜索结果
41 条记录 (耗时 0.036 秒)
