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公开(公告)号：EP3464281B1
公开(公告)日：2020-07-08
申请号：EP17728429.6
申请日：2017-05-30
发明人： LUMERAS AMADOR, Wenceslao , BAUER, Renato A. , BOULET, Serge Louis , BURKHOLDER, Timothy Paul , GILMOUR, Raymond , HAHN, Patric James , CARBALLARES MARTIN, Santiago , RANKOVIC, Zoran
IPC分类号： C07D413/04
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公开(公告)号：EP3464281A1
公开(公告)日：2019-04-10
申请号：EP17728429.6
申请日：2017-05-30
发明人： LUMERAS AMADOR, Wenceslao , BAUER, Renato A. , BOULET, Serge Louis , BURKHOLDER, Timothy Paul , GILMOUR, Raymond , HAHN, Patric James , CARBALLARES MARTIN, Santiago , RANKOVIC, Zoran
IPC分类号： C07D413/04
摘要： The present application provides compounds of Formula I: Formula (I) that are useful as inhibitors of mutant IDH1, pharmaceutical compositions, and uses for the treatment of cancer.
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3.发明公开6-SUBSTITUTED-3H-1,3-BENZOTHIAZOL-2-ONE COMPOUNDS AS TARP-GAMMA 8 DEPENDENT AMPA RECEPTOR ANTAGONISTS 审中-公开6-SUBSTITUIERTE-3H-1,3-BENZOTHIAZOL-2-ON-VERBINDUNGEN ALS TARP-GAMMA-8-ABHÄNGIGEAMPA-REZEPTORANTAGONISTEN
公开(公告)号：EP3148995A1
公开(公告)日：2017-04-05
申请号：EP15726843.4
申请日：2015-05-21
发明人： GARDINIER, Kevin Matthew , GERNERT, Douglas Linn , HAHN, Patric James , HOLLINSHEAD, Sean Patrick , KHILEVICH, Albert , MAYHUGH, Daniel Ray , ORNSTEIN, Paul Leslie , PORTER, Warren Jaye , REEL, Jon Kevin , SCHKERYANTZ, Jeffrey Michael , SPINAZZE, Patrick Gianpietro , STEVENS, Freddie Craig , WITKIN, Jeffrey Michael
IPC分类号： C07D417/14 , A61K31/41 , A61P25/00
摘要： A TARP γ8 dependant AMPA receptor antagonist of the formula: wherein X is CH or N; A is and R1 is as defined herein; its pharmaceutically acceptable salts, uses, and methods for its preparation are described.
摘要翻译： TARPγ8依赖性AMPA受体拮抗剂，其具有下式：其中X是CH或N; A是且R 1如本文所定义; 描述了其药学上可接受的盐，用途及其制备方法。
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4.发明授权
公开(公告)号：EP3555105B1
公开(公告)日：2020-10-28
申请号：EP17822882.1
申请日：2017-12-08
发明人： BAUER, Renato Alejandro , BOULET, Serge Louis , BURKHOLDER, Timothy Paul , GILMOUR, Raymond , HAHN, Patric James , RANKOVIC, Zoran
IPC分类号： C07D498/04 , A61P35/00 , A61K31/5365
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公开(公告)号：EP3148995B1
公开(公告)日：2020-09-23
申请号：EP15726843.4
申请日：2015-05-21
发明人： GARDINIER, Kevin Matthew , GERNERT, Douglas Linn , HAHN, Patric James , HOLLINSHEAD, Sean Patrick , KHILEVICH, Albert , MAYHUGH, Daniel Ray , ORNSTEIN, Paul Leslie , PORTER, Warren Jaye , REEL, Jon Kevin , SCHKERYANTZ, Jeffrey Michael , SPINAZZE, Patrick Gianpietro , STEVENS, Freddie Craig , WITKIN, Jeffrey Michael
IPC分类号： C07D417/14 , A61K31/41 , A61P25/00
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6.发明公开3-(2-ACYLAMINO-1-HYDROXYETHYL)- MORPHOLINE DERIVATIVES AND THEIR USE AS BACE INHIBITORS 审中-公开3-（2-氨基亚氨基-1-羟基乙基）吗啉衍生物在IHRE VERWENDUNG ALS BACE-INHIBITOREN
公开(公告)号：EP2091928A2
公开(公告)日：2009-08-26
申请号：EP05798832.1
申请日：2005-09-20
发明人： DURHAM, Timothy Barrett , HAHN, Patric James , KOHN, Todd Jonathan , MCCARTHY, James Ray , BROUGHTON, Howard Barff Lilly S.A. , DALLY, Robert Dean , GONZALEZ-GARCIA, Maria Rosario Lilly S.A. , HENRY, Kenneth James Jr , SHEPHERD, Timothy Alan , ERICKSON, Jon André , BUENO-MELENDO, Ana Belén Lilly S.A.
IPC分类号： C07D265/30 , C07D265/32 , A61K31/5375 , A61K31/5377 , C07D413/12 , C07C217/48 , C07C271/20 , C07F7/18
CPC分类号： C07C271/20 , C07C233/36 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07C2603/74 , C07D265/30 , C07D265/32 , C07D413/12 , C07F7/1856
摘要： The present invention provides BACE inhibitors of Formula (I); methods for their use and preparation, and intermediates useful for their preparation.
摘要翻译： 本发明提供式（I）的BACE抑制剂; 使用和制备方法，以及可用于制备的中间体。
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