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公开(公告)号：EP2417158B1
公开(公告)日：2017-08-02
申请号：EP10712681.5
申请日：2010-04-06
CPC分类号： C07K16/18 , A61K2039/505 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92
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公开(公告)号：EP2209806A1
公开(公告)日：2010-07-28
申请号：EP08844586.1
申请日：2008-10-29
发明人： CAI, Yuping, Anthony , GATELY, Dennis, Patrick , HE, Luhong , LEUNG, Donmienne, Doen , LUAN, Peng , SWANSON, Barbara, Anne , TANG, Ying , WITCHER, Derrick, Ryan
IPC分类号： C07K16/18
CPC分类号： C07K16/26 , A61K2039/505 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要： Monoclonal antibodies are provided that selectively bind human hepcidin-25 and are characterized as having high affinity for human hepcidin-25 and strong human mature hepcidin neutralizing properties. The antibodies of the invention are useful therapeutically for increasing serum iron levels, reticulocyte count, red blood cell count, hemoglobin, and/or hematocrit in a human and for the treatment and diagnosis of mature hepcidin-promoted disorders such as anemia, in a human subject.
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公开(公告)号：EP2417158B9
公开(公告)日：2017-12-06
申请号：EP10712681.5
申请日：2010-04-06
CPC分类号： C07K16/18 , A61K2039/505 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92
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公开(公告)号：EP2417158A1
公开(公告)日：2012-02-15
申请号：EP10712681.5
申请日：2010-04-06
IPC分类号： C07K16/18
CPC分类号： C07K16/18 , A61K2039/505 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： The invention provides human engineered antibodies, antigen-binding fragments thereof, that bind to, and inhibit the activity of, human DKK-1, and which are effective in treating diseases in which pathogenesis is mediated by DKK-1.
摘要翻译： 本发明提供人类工程化的抗体，其抗原结合片段，其结合并抑制人DKK-1的活性，并且其有效治疗由DKK-1介导的发病机制的疾病。
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