公开(公告)号：EP1246792A1

公开(公告)日：2002-10-09

申请号：EP01908609.9

申请日：2001-01-12

申请人： Emisphere Technologies, Inc.

发明人： BOYD, Maria, Aurora, P. ,  LEONE-BAY, Andrea ,  O'TOOLE, Doris, C.

IPC分类号： C07C229/00 ,  A61K38/28 ,  A61K51/00

CPC分类号： A61K31/195 ,  A61K9/0053 ,  A61K9/0073 ,  A61K31/557 ,  A61K31/727 ,  A61K38/21 ,  A61K38/23 ,  A61K38/27 ,  A61K38/28 ,  A61K38/29 ,  A61K47/183 ,  A61K47/541 ,  C07C235/64 ,  A61K2300/00

摘要： Compounds and compositions for the delivery of active agents are provided. Methods of administration and preparation are provided as well.

公开(公告)号：EP1284724B1

公开(公告)日：2012-04-18

申请号：EP01959913.3

申请日：2001-03-21

申请人： Emisphere Technologies, Inc.

发明人： BERNADINO, Joseph, N. ,  O'TOOLE, Doris, C. ,  BAY, William, E.

IPC分类号： C07C231/12 ,  C07C235/60 ,  C07D265/22 ,  C07D265/26

CPC分类号： C07D265/22 ,  C07C231/12 ,  C07C235/60 ,  C07D265/26 ,  Y02P20/55

摘要： The present invention relates to a method of preparing an alkylated salicylamide from a protected and activated salicylamide via a dicarboxylated salicylamide intermediate. The present invention also relates to dicarboxylic salicylamide delivery agent compounds for the delivery of active agents. Methods of administration are provided as well.

公开(公告)号：EP1284724A1

公开(公告)日：2003-02-26

申请号：EP01959913.3

申请日：2001-03-21

申请人： Emisphere Technologies, Inc.

发明人： BERNADINO, Joseph, N. ,  O'TOOLE, Doris, C. ,  BAY, William, E.

IPC分类号： A61K31/195 ,  C07D265/12 ,  C07C229/00 ,  C07C233/00 ,  C07C235/00 ,  C07C237/00 ,  C07C239/00

CPC分类号： C07D265/22 ,  C07C231/12 ,  C07C235/60 ,  C07D265/26 ,  Y02P20/55

摘要： The present invention relates to a method of preparing an alkylated salicylamide from a protected and activated salicylamide via a dicarboxylated salicylamide intermediate. The present invention also relates to dicarboxylic salicylamide delivery agent compounds for the delivery of active agents. Methods of administration are provided as well.

公开(公告)号：EP1246792B1

公开(公告)日：2014-08-13

申请号：EP01908609.9

申请日：2001-01-12

申请人： Emisphere Technologies, Inc.

发明人： BOYD, Maria, Aurora, P. ,  LEONE-BAY, Andrea ,  O'TOOLE, Doris, C.

IPC分类号： C07C229/00 ,  A61K38/28 ,  A61K51/00

CPC分类号： A61K31/195 ,  A61K9/0053 ,  A61K9/0073 ,  A61K31/557 ,  A61K31/727 ,  A61K38/21 ,  A61K38/23 ,  A61K38/27 ,  A61K38/28 ,  A61K38/29 ,  A61K47/183 ,  A61K47/541 ,  C07C235/64 ,  A61K2300/00

公开(公告)号：EP1937627A2

公开(公告)日：2008-07-02

申请号：EP06814934.3

申请日：2006-09-18

申请人： Emisphere Technologies, Inc.

发明人： DHOOT, Nikhil ,  BAY, William, Elliot ,  DINH, Steven ,  MAJURU, Shingai ,  CORVINO, JoAnne, P. ,  O'TOOLE, Doris, C.

IPC分类号： C07C235/32

CPC分类号： A61K47/18 ,  C07B2200/13 ,  C07C231/24 ,  C07C235/52 ,  C07C235/60

摘要： The present invention relates to crystalline polymorphic forms of the di- sodium salt of N-(5-chlorosalicyloyl)-8-aminocaprylic acid, pharmaceutical compositions containing the same, methods of preparing the same, and methods for facilitating the delivery of active agents with the same.