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公开(公告)号：EP1077070A2
公开(公告)日：2001-02-21
申请号：EP00118505.7
申请日：1994-04-22
发明人： Milstein, Sam J. , Barantsevitch, Evgueni N. , Sarubbi, Donald J. , Leone-Bay, Andrea , Paton, Duncan R.
CPC分类号： A61K31/16 , A61K9/1617 , A61K31/352 , A61K31/727 , A61K38/212 , A61K38/23 , A61K38/25 , A61K38/27 , C07C229/42 , C07C233/55 , C07C233/63 , C07C233/87 , C07C235/38 , C07C235/64 , C07C235/84 , C07C237/22 , C07C2601/02 , C07C2601/14 , C07C2601/18
摘要： The present invention relates to an oral drug delivery system, and in particular to modified amino acids and modified amino acid derivatives for use as a delivery system of sensitive agents such as bioactive peptides. The modified amino acids and derivatives can form non-covalent mixtures with active biological agents and in an alternate embodiment can releasably carry active agents. Modified amino acids can also form durg containing microspheres. These mixtures are suitable for oral administration of biologically active agents to animals. Methods for the preparation of such amino acids are also disclosed.
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公开(公告)号：EP1025840B1
公开(公告)日：2005-06-29
申请号：EP00103527.8
申请日：1994-04-22
发明人： Milstein, Sam J. , Barantsevitch, Evgueni N. , Sarubbi, Donald J. , Leone-Bay, Andrea , Paton, Duncan R.
IPC分类号： A61K9/16
CPC分类号： A61K31/16 , A61K9/1617 , A61K31/352 , A61K31/727 , A61K38/212 , A61K38/23 , A61K38/25 , A61K38/27 , C07C229/42 , C07C233/55 , C07C233/63 , C07C233/87 , C07C235/38 , C07C235/64 , C07C235/84 , C07C237/22 , C07C2601/02 , C07C2601/14 , C07C2601/18
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公开(公告)号：EP1025840A2
公开(公告)日：2000-08-09
申请号：EP00103527.8
申请日：1994-04-22
发明人： Milstein, Sam J. , Barantsevitch, Evgueni N. , Sarubbi, Donald J. , Leone-Bay, Andrea , Paton, Duncan R.
CPC分类号： A61K31/16 , A61K9/1617 , A61K31/352 , A61K31/727 , A61K38/212 , A61K38/23 , A61K38/25 , A61K38/27 , C07C229/42 , C07C233/55 , C07C233/63 , C07C233/87 , C07C235/38 , C07C235/64 , C07C235/84 , C07C237/22 , C07C2601/02 , C07C2601/14 , C07C2601/18
摘要： The present invention relates to an oral drug delivery system, and in particular to modified amino acids and modified amino acid derivatives for use as a delivery system of sensitive agents such as bioactive peptides. The modified amino acids and derivatives can form non-covalent mixtures with active biological agents and in an alternate embodiment can releasably carry active agents. Modified amino acids can also form durg containing microspheres. These mixtures are suitable for oral administration of biologically active agents to animals. Methods for the preparation of such amino acids are also disclosed.
摘要翻译： 口服药物递送系统技术领域本发明涉及一种口服药物递送系统，并且具体地涉及用作敏感试剂如生物活性肽的递送系统的修饰氨基酸和修饰氨基酸衍生物。 修饰的氨基酸和衍生物可以与活性生物制剂形成非共价混合物，并且在另一个实施方案中可以可释放地携带活性剂。 修饰的氨基酸也可以形成含有微球体的durg。 这些混合物适用于将生物活性剂口服给予动物。 还公开了制备这些氨基酸的方法。
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公开(公告)号：EP1077070A3
公开(公告)日：2001-05-23
申请号：EP00118505.7
申请日：1994-04-22
发明人： Milstein, Sam J. , Barantsevitch, Evgueni N. , Sarubbi, Donald J. , Leone-Bay, Andrea , Paton, Duncan R.
CPC分类号： A61K31/16 , A61K9/1617 , A61K31/352 , A61K31/727 , A61K38/212 , A61K38/23 , A61K38/25 , A61K38/27 , C07C229/42 , C07C233/55 , C07C233/63 , C07C233/87 , C07C235/38 , C07C235/64 , C07C235/84 , C07C237/22 , C07C2601/02 , C07C2601/14 , C07C2601/18
摘要： The present invention relates to an oral drug delivery system, and in particular to modified amino acids and modified amino acid derivatives for use as a delivery system of sensitive agents such as bioactive peptides. The modified amino acids and derivatives can form non-covalent mixtures with active biological agents and in an alternate embodiment can releasably carry active agents. Modified amino acids can also form durg containing microspheres. These mixtures are suitable for oral administration of biologically active agents to animals. Methods for the preparation of such amino acids are also disclosed.
摘要翻译： 口服药物递送系统技术领域本发明涉及一种口服药物递送系统，并且具体地涉及用作敏感试剂如生物活性肽的递送系统的修饰氨基酸和修饰氨基酸衍生物。 修饰的氨基酸和衍生物可以与活性生物制剂形成非共价混合物，并且在另一个实施方案中可以可释放地携带活性剂。 修饰的氨基酸也可以形成含有微球体的durg。 这些混合物适用于将生物活性剂口服给予动物。 还公开了制备这些氨基酸的方法。
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公开(公告)号：EP1025840A3
公开(公告)日：2000-08-30
申请号：EP00103527.8
申请日：1994-04-22
发明人： Milstein, Sam J. , Barantsevitch, Evgueni N. , Sarubbi, Donald J. , Leone-Bay, Andrea , Paton, Duncan R.
IPC分类号： A61K9/16
CPC分类号： A61K31/16 , A61K9/1617 , A61K31/352 , A61K31/727 , A61K38/212 , A61K38/23 , A61K38/25 , A61K38/27 , C07C229/42 , C07C233/55 , C07C233/63 , C07C233/87 , C07C235/38 , C07C235/64 , C07C235/84 , C07C237/22 , C07C2601/02 , C07C2601/14 , C07C2601/18
摘要： The present invention relates to an oral drug delivery system, and in particular to modified amino acids and modified amino acid derivatives for use as a delivery system of sensitive agents such as bioactive peptides. The modified amino acids and derivatives can form non-covalent mixtures with active biological agents and in an alternate embodiment can releasably carry active agents. Modified amino acids can also form durg containing microspheres. These mixtures are suitable for oral administration of biologically active agents to animals. Methods for the preparation of such amino acids are also disclosed.
摘要翻译： 本发明涉及口服药物递送系统，特别涉及用作敏感剂如生物活性肽的递送系统的修饰氨基酸和修饰的氨基酸衍生物。 修饰的氨基酸和衍生物可以与活性生物制剂形成非共价混合物，并且在替代实施方案中可释放地携带活性剂。 改性氨基酸也可以形成含有微球的含糖。 这些混合物适合于向动物口服给药生物活性剂。 还公开了制备这些氨基酸的方法。
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