公开(公告)号：EP3684911A1

公开(公告)日：2020-07-29

申请号：EP18857584.9

申请日：2018-09-21

申请人： Emulate, Inc.

发明人： VARONE, Antonio ,  KASENDRA, Magdalena ,  LUCCHESI, Carolina ,  KERNS, S. Jordan ,  BARRILE, Riccardo ,  BARTHAKUR, Sonalee

IPC分类号： C12M3/00 ,  B01L3/00 ,  C12M1/34

公开(公告)号：EP3990186A1

公开(公告)日：2022-05-04

申请号：EP20831828.7

申请日：2020-06-26

申请人： Emulate, Inc.

发明人： SLIZ, Josiah ,  LEVNER, Daniel ,  ZUCKERMAN, Brian ,  WEN, Norman ,  RUBINS, Jonathan ,  SHROFF, Tanvi ,  HINOJOSA, Christopher David ,  AHN, Grace ,  ANTONTSEV, Victor ,  PUERTA, Jefferson ,  CONEGLIANO, David ,  KERNS, S. Jordan

IPC分类号： B01L3/00 ,  B01D19/00 ,  B01D53/22 ,  C12M3/06 ,  C12M1/04 ,  G01N1/40

公开(公告)号：EP3484991A1

公开(公告)日：2019-05-22

申请号：EP17828406.3

申请日：2017-07-12

申请人： Emulate, Inc.

发明人： LEVNER, Daniel ,  HUH, Dongeun, Huh ,  JANG, Kyung, Jin ,  FRASER, Jacob ,  KERNS, S. Jordan ,  VARONE, Antonio

IPC分类号： C12M1/12 ,  C12N5/07 ,  G01N33/50

公开(公告)号：EP3411470A2

公开(公告)日：2018-12-12

申请号：EP17748084.5

申请日：2017-02-01

申请人： Emulate, Inc. ,  Cedars-Sinai Medical Center

发明人： KERNS, S. Jordan ,  WEN, Norman ,  LUCCHESI, Carol ,  HINOJOSA, Christopher David ,  FRASER, Jacob ,  PUERTA, Jefferson ,  HAMILTON, Geraldine ,  BARRETT, Robert ,  SVENDSEN, Clive ,  LEVNER, Daniel ,  TARGAN, Stephen R. ,  WORKMAN, Michael ,  SAREEN, Dhruv ,  RAJAMANI, Uthra ,  KASENDRA, Magdalena

IPC分类号： C12N5/02 ,  C12N5/074 ,  C12N5/0793 ,  C12N5/0797

CPC分类号： C12N5/0696 ,  C12M23/16 ,  C12N5/0679 ,  C12N2501/11 ,  C12N2501/119 ,  C12N2501/16 ,  C12N2501/24 ,  C12N2501/415 ,  C12N2501/998 ,  C12N2506/45 ,  C12N2535/00

摘要： Organs-on-chips are microfluidic devices for culturing living cells in micrometer sized chambers in order to model physiological functions of tissues and organs. Engineered patterning and continuous fluid flow in these devices has allowed culturing of intestinal cells bearing physiologically relevant features and sustained exposure to bacteria while maintaining cellular viability, thereby allowing study of inflammatory bowl diseases. However, existing intestinal cells do not possess all physiologically relevant subtypes, do not possess the repertoire of genetic variations, or allow for study of other important cellular actors such as immune cells. Use of iPSC-derived epithelium, including IBD patient-specific cells, allows for superior disease modeling by capturing the multi-faceted nature of the disease.