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公开(公告)号：EP3963070A1
公开(公告)日：2022-03-09
申请号：EP20798020.2
申请日：2020-04-10
申请人： Encodia, Inc.
IPC分类号： C12N15/10 , C40B70/00 , G01N33/58 , C12Q1/6869 , C12Q1/6806
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公开(公告)号：EP4206674A1
公开(公告)日：2023-07-05
申请号：EP22216833.8
申请日：2022-12-27
申请人： Encodia, Inc.
发明人： OKERBERG, Eric , GUNDERSON, Kevin L. , MURANAKA, Norihito , KIM, Jongbum , LIM, Byung Joon , SHI, Lei , GANGULY, Soumya , SULLIVAN, Devin
IPC分类号： G01N33/68 , G01N33/569
摘要： Provided herein are high-throughput, population-wide serotyping and antibody profiling assays. Disclosed variants of a Digital Serotyping assay employ next generation sequencing to measure the "serotyping profile" of barcoded subject serum antibodies tested against a range of DNA-tagged pathogen-derived antigens. The disclosed assay setup enables multiplexing in both the sample and antigen dimensions, generating a large multi-dimensional serotyping data set for more comprehensive serotyping profiling of large populations across a large number of antigens and possible pathogens. Moreover, the ability to easily scale and multiplex the number of peptide epitopes allows rapid updating of the assay content to monitor the ever-changing spectrum of pathogens. Additional applications of this technology include cancer immunology and autoimmune conditions ( e.g ., neoantigen or autoimmune profiling), screening for toxins, antibody therapeutics development, biosecurity, and veterinary medicine.
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公开(公告)号：EP4073263A1
公开(公告)日：2022-10-19
申请号：EP21737980.9
申请日：2021-01-05
申请人： Encodia, Inc.
IPC分类号： C12Q1/68 , C12Q1/6811 , C12Q1/6869 , C40B20/04 , C40B70/00 , G01N33/543
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