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公开(公告)号：EP3740217A1
公开(公告)日：2020-11-25
申请号：EP19740881.8
申请日：2019-01-22
申请人： Endocyte, Inc. , Purdue Research Foundation , Seattle Children's Hospital (DBA Seattle Children's Research Institute)
发明人： LOW, Philip Stewart , CHU, Haiyan , LU, Yingjuan June , LEAMON, Christopher Paul , WHEELER, Leroy W. II , JENSEN, Michael C. , MATTHAEI, James
IPC分类号： A61K35/17 , A61K39/385 , A61P35/00
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公开(公告)号：EP3589295A1
公开(公告)日：2020-01-08
申请号：EP18761400.3
申请日：2018-02-28
发明人： LOW, Philip Stewart , CHU, Haiyan , LEE, Yong Gu , LU, Yingjuan J. , LEAMON, Christopher Paul , WHEELER II, Leroy W.
IPC分类号： A61K35/17 , C07K14/725 , C07K14/705 , C07K16/28
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公开(公告)号：EP3463367A1
公开(公告)日：2019-04-10
申请号：EP17803611.7
申请日：2017-05-25
发明人： LOW, Philip Stewart , WANG, Bingbing , LEAMON, Christopher Paul , LU, Yingjuan J. , WHEELER II, Leroy W.
IPC分类号： A61K31/519 , A61K51/04 , A61K38/07
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公开(公告)号：EP3197502A1
公开(公告)日：2017-08-02
申请号：EP15843633.7
申请日：2015-09-24
申请人： Endocyte, Inc.
发明人： LEAMON, Christopher Paul , REDDY, Joseph Anand , NGUYEN, Binh , BLOOMFIELD, Alicia , NELSON, Melissa , DORTON, Ryan
CPC分类号： A61K38/05 , A61K31/519 , A61K47/48338 , A61K47/551 , A61K47/645 , A61K51/0459 , A61K51/088
摘要： The invention described herein pertains to drug delivery conjugates for targeted therapy. The invention described herein relates to methods of treating folate receptor-expressing cancers with a folate-tubulysin conjugate. The invention described herein also relates to methods of treating folate-expressing cancers with a folate tubulysin conjugate in patients where stable disease results after treatment with the folate-tubulysin conjugate.
摘要翻译： 本文所述的发明涉及用于靶向治疗的药物递送缀合物。 本文所述的发明涉及用叶酸 - 微管溶素结合物治疗表达叶酸受体的癌症的方法。 本文所述的发明还涉及在用叶酸 - 微管溶素结合物治疗后导致稳定疾病的患者中用叶酸盐微管蛋白结合物治疗表达叶酸的癌症的方法。
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公开(公告)号：EP3334466A1
公开(公告)日：2018-06-20
申请号：EP16837542.6
申请日：2016-08-11
申请人： Endocyte, Inc.
摘要： The present disclosure relates to a method for imaging cancer by administering to a patient a labeled chelating compound and an unlabeled chelating compound.
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公开(公告)号：EP3334447A1
公开(公告)日：2018-06-20
申请号：EP16837521.0
申请日：2016-08-10
申请人： Endocyte, Inc.
发明人： PARHAM, Garth L. , NELSON, Melissa , VETZEL, Marilynn , DIRCKSEN, Christina M. , REDDY, Joseph Anand , LEAMON, Christopher Paul , VLAHOV, Iontcho Radoslavov
IPC分类号： A61K38/03 , A61K38/14 , C07D243/12
CPC分类号： A61K47/64 , A61K31/5513 , A61K38/03 , A61K38/07 , A61K38/14 , A61K49/00 , A61K51/088 , A61P35/00 , C07D209/20 , C07D243/12 , C07D405/14 , C07D417/14
摘要： The disclosure provided herein pertains to CCK2R-drug conjugates. In particular, the disclosure pertains to CCK2R-drug conjugates that target the delivery of drugs to a mammalian recipient. Also described are methods of making and using CCK2R-drug conjugates.
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公开(公告)号：EP2831059B1
公开(公告)日：2017-11-29
申请号：EP13770372.4
申请日：2013-03-29
申请人： Endocyte, Inc.
发明人： VLAHOV, Iontcho Radoslavov , SANTHAPURAM, Hari Krishna R , KLEINDL, Paul Joseph , LEAMON, Christopher Paul , YOU, Fei
IPC分类号： C07D401/12
CPC分类号： C07D417/14 , C07C241/02 , C07D213/71 , C07D213/76 , C07D277/56 , C07D417/12 , C07F7/188 , C07F7/1892 , C07K5/02 , C07K7/02
摘要： The invention described herein pertains to processes for preparing tubulysin derivatives, conjugates of tubulysins, and intermediates therefore.
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公开(公告)号：EP3875082A1
公开(公告)日：2021-09-08
申请号：EP21150716.5
申请日：2013-11-14
申请人： Endocyte, Inc.
发明人： VLAHOV, Iontcho Radoslavov , REDDY, Joseph Anand , BLOOMFIELD, Alicia , DORTON, Ryan , NELSON, Melissa , VETZEL, Marilynn , LEAMON, Christopher Paul
IPC分类号： A61K31/17 , A61K49/00 , A61K49/10 , A61P35/00 , A61K38/05 , A61K38/00 , A61K38/06 , A61K38/07 , A61K38/08 , A61K47/54 , A61K47/64 , C07K5/02 , C07K5/072 , C07K5/11 , A61P13/08 , A61P13/10
摘要： The invention described herein pertains to the diagnosis, imaging, and/or treatment of pathogenic cell populations. In particular, the invention described herein pertains to the diagnosis, imaging, and/or treatment of diseases caused by PSMA expressing cells, such as prostate cancer cells, using a conjugate of the general formula B-L-(D)n as further defined in the claims.
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公开(公告)号：EP3600430A1
公开(公告)日：2020-02-05
申请号：EP17903862.5
申请日：2017-09-14
申请人： Endocyte, Inc.
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10.发明公开
公开(公告)号：EP2831059A1
公开(公告)日：2015-02-04
申请号：EP13770372.4
申请日：2013-03-29
申请人： Endocyte, Inc.
发明人： VLAHOV, Iontcho Radoslavov , SANTHAPURAM, Hari Krishna R , KLEINDL, Paul Joseph , LEAMON, Christopher Paul , YOU, Fei
IPC分类号： C07D401/12
CPC分类号： C07D417/14 , C07C241/02 , C07D213/71 , C07D213/76 , C07D277/56 , C07D417/12 , C07F7/188 , C07F7/1892 , C07K5/02 , C07K7/02
摘要： The invention described herein pertains to processes for preparing tubulysin derivatives, conjugates of tubulysins, and intermediates therefore. In one illustrative embodiment of the invention, processes for derivatives or analogs of natural tubulysins including compounds of formula (T). In another embodiment, vitamin receptor binding conjugates of tubulysins are described. The processes include one or more steps described herein. In another embodiment, a process is described for preparing a compound of formula B, wherein R5 and R6 are as described in the various embodiments herein, such as each being independently selected from optionally substituted alkyl or optionally substituted cycloalkyl; and R8 is C1-C6 n-alkyl; wherein the process comprises the step of treating a compound of formula A with a silylating agent, such as triethylsilyl chloride, and a base, such as imidazole in an aprotic solvent.
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