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公开(公告)号：EP2776409B1
公开(公告)日：2016-02-03
申请号：EP12787341.2
申请日：2012-11-09
发明人： SEIGAL, Benjamin, Adam , TERRETT, Nicholas , CARTER, Percy, H. , BORZILLERI, Robert, M. , ZHANG, Yong , MILLER, Michael, M.
IPC分类号： C07D249/04 , A61P35/00
CPC分类号： C07D498/22 , A61K38/00 , C07D249/04 , C07D498/16 , C07K5/1008 , C07K7/56 , Y02A50/411 , Y02A50/414
摘要： The invention relates generally to macrocyclic compounds and their therapeutic use. More particularly, the invention relates to macrocyclic compounds that modulate the activity of inhibitors of apoptosis (IAPs) and/or are useful in the treatment of medical conditions, such as cancer.
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公开(公告)号：EP2776409A1
公开(公告)日：2014-09-17
申请号：EP12787341.2
申请日：2012-11-09
发明人： SEIGAL, Benjamin, Adam , TERRETT, Nicholas , CARTER, Percy, H. , BORZILLERI, Robert, M. , ZHANG, Yong , MILLER, Michael, M.
IPC分类号： C07D249/04 , A61P35/00
CPC分类号： C07D498/22 , A61K38/00 , C07D249/04 , C07D498/16 , C07K5/1008 , C07K7/56 , Y02A50/411 , Y02A50/414
摘要： The invention relates generally to macrocyclic compounds and their therapeutic use. More particularly, the invention relates to macrocyclic compounds that modulate the activity of inhibitors of apoptosis (IAPs) and/or are useful in the treatment of medical conditions, such as cancer.
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3.发明公开IMIDAZOTHIADIAZOLE AND IMIDAZOPYRIDAZINE DERIVATIVES AS PROTEASE ACTIVATED RECEPTOR 4 (PAR4) INHIBITORS FOR TREATING PLATELET AGGREGATION 有权IMIDAZOTHIADIAZOL-和咪唑并哒嗪衍生物作为蛋白酶活化受体4（PAR4）抑制剂用于治疗血小板聚集
公开(公告)号：EP2855489A1
公开(公告)日：2015-04-08
申请号：EP13719360.3
申请日：2013-04-24
发明人： PRIESTLEY, Eldon Scott , POSY, Shoshana L. , TREMBLAY, Francois , MARTEL, Alain , MARINIER, Anne , MILLER, Michael, M. , LAWRENCE, R., Michael
IPC分类号： C07D519/00 , A61K31/433 , A61K31/4439 , C07D513/04 , A61K31/5025 , C07D487/04 , A61P7/02
CPC分类号： C07D513/04 , A61K31/433 , A61K31/437 , A61K31/4439 , A61K31/497 , A61K31/506 , A61K31/513 , A61K31/5377 , A61K38/12 , C07D487/04
摘要： The present invention provides imidazothiadiazole compounds of Formula (I); Wherein W,Y, R
0 , R
2 , R
4 , R
a , R
b , X
1 , X
2 , X
3 and X
4 are as defined herein,, or a stereoisomer, tautomer, pharmaceutically acceptable salt, prodrug ester or solvate form thereof, wherein all of the variables are as defined herein. These compounds are inhibitors of platelet aggregation and thus can be used as medicaments for treating or preventing thromboembolic disorders.-
4.发明公开IMIDAZOTHIADIAZOLE DERIVATIVES AS PROTEASE ACTIVATED RECEPTOR 4 (PAR4) INHIBITORS FOR TREATING PLATELET AGGREGATION 有权IMIDAZOTHIADIAZOLDERIVATE ALS PROTEASEAKTIVIERTE REZEPTOR 4（PAR4）-HEMMER ZUR BEHANDLUNG VON THROMBOZYTEGGEGATION
公开(公告)号：EP2847200A1
公开(公告)日：2015-03-18
申请号：EP13719361.1
申请日：2013-04-24
发明人： LAWRENCE, R. Michael , MILLER, Michael, M. , SEIFFERT, Dietmar, Alfred , POSY, Shoshana, L. , WONG, Pancras, C. , BANVILLE, Jacques , RUEDIGER, Edward, H. , DEON, Daniel, H. , MARTEL, Alain , TREMBLAY, Francois , GUY, Julia , LAVALLEE, Jean-Francois , GAGNON, Marc
IPC分类号： C07D519/00 , A61K31/433 , A61K31/4439 , C07D513/04 , A61P7/02
CPC分类号： C07D513/04 , A61K31/433 , A61K31/4355 , A61K31/4439 , A61K31/506 , A61K31/5377 , A61K45/06 , C07D519/00
摘要： The present invention provides imidazothiadiazole compounds of Formula (I) wherein A, B, D, Rx, R1, R2, R3, X1, X2 and s are as defined herein, or a stereoisomer, tautomer, pharmaceutically acceptable salt or solvate form thereof, wherein all of the variables are as defined herein. These compounds are inhibitors of platelet aggregation and thus can be used as medicaments.
摘要翻译： 本发明提供式（I）的咪唑并噻二唑化合物，其中A，B，D，Rx，R 1，R 2，R 3，X 1，X 2和s如本文所定义，或其立体异构体，互变异构体，药学上可接受的盐或溶剂化物形式， 其中所有变量如本文所定义。 这些化合物是血小板聚集的抑制剂，因此可以用作药物。
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5.发明公开IMIDAZOTHIADIAZOLE AND IMIDAZOPYRAZINE DERIVATIVES AS PROTEASE ACTIVATED RECEPTOR 4 (PAR4) INHIBITORS FOR TREATING PLATELET AGGREGATION 有权IMIDAZOTHIADIAZOL- AND IMIDAZOPYRAZINDERIVATE AS蛋白酶活化受体4（PAR4）抑制剂用于治疗血小板聚集
公开(公告)号：EP2841437A1
公开(公告)日：2015-03-04
申请号：EP13721857.4
申请日：2013-04-24
发明人： BANVILLE, Jacques , RÉMILLARD, Roger , RUEDIGER, Edward H. , DEON, Daniel H. , GAGNON, Marc , DUBÉ, Laurence , GUY, Julia , PRIESTLEY, Eldon Scott , POSY, Shoshana L. , MAXWELL, Brad D. , WONG, Pancras C. , LAWRENCE, Michael, R. , MILLER, Michael, M.
IPC分类号： C07D519/00 , A61K31/433 , C07D513/04 , A61K31/5025 , C07D487/04 , A61K31/4355 , A61P7/02
CPC分类号： C07D513/04 , A61K31/433 , A61K31/435 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/497 , A61K31/5025 , A61K31/5377 , A61K31/5386 , A61K31/541 , A61K31/55 , A61K31/553 , A61K45/06 , A61K51/0453 , C07B59/002 , C07B2200/05 , C07D487/04 , C07D519/00
摘要： The present invention provides thiazole compounds of Formula I wherein W, Y, R
0 , R
2 , R
4 , R
5 , R
6 , R
7 , X
1 , X
2 , X
3 and X
4 are as defined herein, or a stereoisomer, tautomer, pharmaceutically acceptable salt, prodrug ester or solvate form thereof, wherein all of the variables are as defined herein. These compounds are inhibitors of platelet aggregation and thus can be used as medicaments for treating or preventing thromboembolic disorders.-
6.发明授权IMIDAZOTHIADIAZOLE AND IMIDAZOPYRIDAZINE DERIVATIVES AS PROTEASE ACTIVATED RECEPTOR 4 (PAR4) INHIBITORS FOR TREATING PLATELET AGGREGATION 有权IMIDAZOTHIADIAZOL-和咪唑并哒嗪衍生物作为蛋白酶活化受体4（PAR4）抑制剂用于治疗血小板聚集
公开(公告)号：EP2855489B1
公开(公告)日：2017-01-04
申请号：EP13719360.3
申请日：2013-04-24
发明人： PRIESTLEY, Eldon Scott , POSY, Shoshana L. , TREMBLAY, Francois , MARTEL, Alain , MARINIER, Anne , MILLER, Michael, M. , LAWRENCE, R., Michael
IPC分类号： C07D519/00 , A61K31/433 , A61K31/4439 , C07D513/04 , A61K31/5025 , C07D487/04 , A61P7/02
CPC分类号： C07D513/04 , A61K31/433 , A61K31/437 , A61K31/4439 , A61K31/497 , A61K31/506 , A61K31/513 , A61K31/5377 , A61K38/12 , C07D487/04
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7.发明授权IMIDAZOTHIADIAZOLE AND IMIDAZOPYRAZINE DERIVATIVES AS PROTEASE ACTIVATED RECEPTOR 4 (PAR4) INHIBITORS FOR TREATING PLATELET AGGREGATION 有权作为蛋白酶激活的受体4（PAR4）抑制剂治疗血小板聚集的咪唑并二氮杂和咪唑并吡嗪衍生物
公开(公告)号：EP2841437B1
公开(公告)日：2017-07-05
申请号：EP13721857.4
申请日：2013-04-24
发明人： BANVILLE, Jacques , RÉMILLARD, Roger , RUEDIGER, Edward H. , DEON, Daniel H. , GAGNON, Marc , DUBÉ, Laurence , GUY, Julia , PRIESTLEY, Eldon Scott , POSY, Shoshana L. , MAXWELL, Brad D. , WONG, Pancras C. , LAWRENCE, Michael, R. , MILLER, Michael, M.
IPC分类号： C07D519/00 , A61K31/433 , C07D513/04 , A61K31/5025 , C07D487/04 , A61K31/4355 , A61P7/02
CPC分类号： C07D513/04 , A61K31/433 , A61K31/435 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/497 , A61K31/5025 , A61K31/5377 , A61K31/5386 , A61K31/541 , A61K31/55 , A61K31/553 , A61K45/06 , A61K51/0453 , C07B59/002 , C07B2200/05 , C07D487/04 , C07D519/00
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8.发明授权IMIDAZOTHIADIAZOLE DERIVATIVES AS PROTEASE ACTIVATED RECEPTOR 4 (PAR4) INHIBITORS FOR TREATING PLATELET AGGREGATION 有权IMIDAZOTHIADIAZOLDERIVATE AS蛋白酶活化受体4（PAR4）抑制剂用于治疗血小板聚集
公开(公告)号：EP2847200B1
公开(公告)日：2017-03-29
申请号：EP13719361.1
申请日：2013-04-24
发明人： LAWRENCE, R. Michael , MILLER, Michael, M. , SEIFFERT, Dietmar, Alfred , POSY, Shoshana, L. , WONG, Pancras, C. , BANVILLE, Jacques , RUEDIGER, Edward, H. , DEON, Daniel, H. , MARTEL, Alain , TREMBLAY, Francois , GUY, Julia , LAVALLEE, Jean-Francois , GAGNON, Marc
IPC分类号： C07D519/00 , A61K31/433 , A61K31/4439 , C07D513/04 , A61P7/02
CPC分类号： C07D513/04 , A61K31/433 , A61K31/4355 , A61K31/4439 , A61K31/506 , A61K31/5377 , A61K45/06 , C07D519/00
摘要： The present invention provides imidazothiadiazole compounds of Formula (I) wherein A, B, D, Rx, R1, R2, R3, X1, X2 and s are as defined herein, or a stereoisomer, tautomer, pharmaceutically acceptable salt or solvate form thereof, wherein all of the variables are as defined herein. These compounds are inhibitors of platelet aggregation and thus can be used as medicaments.
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