公开(公告)号：EP1945806A1

公开(公告)日：2008-07-23

申请号：EP06805804.9

申请日：2006-09-21

申请人： Epigenomics AG

发明人： FOEKENS, John ,  MARTENS, John ,  EPPENBERGER-CASTORI, Serenella ,  VUAROQUEAUX, Vincent ,  SPYRATOS, Frédérique ,  HARBECK, Nadia ,  SCHMITT, Manfred ,  HÖFLER, Heinz ,  MAIER, Sabine ,  WEISS, Gunter ,  LESCHE, Ralf ,  HILDMANN, Thomas ,  PLUM, Achim

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/118 ,  C12Q2600/154 ,  C12Q2600/156 ,  C12Q2600/16

摘要： The present invention relates to methods for predicting the outcome of anthracycline treatment of cell proliferative disorder patients. This is achieved by determining the expression level of at least one gene selected from the group consisting of PITX2; TFFl and PLAU. The invention also relates to sequences, oligonucleotides and antibodies which can be used within the described methods.

公开(公告)号：EP2255017A1

公开(公告)日：2010-12-01

申请号：EP09722949.6

申请日：2009-03-18

申请人： Epigenomics AG

发明人： WEISS, Gunter

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/154 ,  C12Q2600/156 ,  C12Q2600/16

摘要： The invention relates to a method for validation of an assay for determining the presence or absence of a medical condition, wherein the nucleic acid has been treated such that all unmethylated cytosine bases are converted to uracils. According to the invention, the method comprises: a) measuring the concentration of the nucleic acid in biological samples; b) allotting the samples based on the measured concentration of the nucleic acid in the sample to a first sample group if the concentration of the nucleic acid is below a given threshold value, or to a second sample group if the concentration of the nucleic acid is above the given threshold value; c) performing an assay for determining the methylation status of the nucleic acid in the sample obtaining methylation signals, and d) applying a first algorithm to the value if the sample was allotted to the first sample group, or a second algorithm if the sample was allotted to the second sample group.

公开(公告)号：EP1945806B1

公开(公告)日：2013-02-27

申请号：EP06805804.9

申请日：2006-09-21

申请人： Epigenomics AG

发明人： FOEKENS, John ,  MARTENS, John ,  EPPENBERGER-CASTORI, Serenella ,  VUAROQUEAUX, Vincent ,  SPYRATOS, Frédérique ,  HARBECK, Nadia ,  SCHMITT, Manfred ,  HÖFLER, Heinz ,  MAIER, Sabine ,  WEISS, Gunter ,  LESCHE, Ralf ,  HILDMANN, Thomas ,  PLUM, Achim

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/118 ,  C12Q2600/154 ,  C12Q2600/156 ,  C12Q2600/16

公开(公告)号：EP1831399B1

公开(公告)日：2009-08-05

申请号：EP05853011.4

申请日：2005-12-02

申请人： Epigenomics AG

发明人： COTTRELL, Susan ,  MODEL, Fabian ,  HAEFLIGER, Carolina ,  WEISS, Gunter ,  DISTLER, Jürgen ,  SLEDZIEWSKI, Andrew, Z. ,  SONG, Xiaoling ,  SKILLMAN, Thomas, L. ,  THOMAS, Jeffrey G.

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/118 ,  C12Q2600/154 ,  C12Q2600/158 ,  C12Q2600/16 ,  G01N33/57434 ,  G01N2800/60

摘要： Particular aspects provide novel methods and compositions (e.g., nucleic acids, kits, etc.) having substantial utility for providing a prognosis of prostate cell proliferative disorders. In particular aspects, this is achieved by the analysis of the expression status of a panel of genes, or subsets thereof.

公开(公告)号：EP1831399A2

公开(公告)日：2007-09-12

申请号：EP05853011.4

申请日：2005-12-02

申请人： Epigenomics AG

发明人： COTTRELL, Susan ,  MODEL, Fabian ,  HAEFLIGER, Carolina ,  WEISS, Gunter ,  DISTLER, Jürgen ,  SLEDZIEWSKI, Andrew, Z. ,  SONG, Xiaoling ,  SKILLMAN, Thomas, L. ,  THOMAS, Jeffrey G.

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/118 ,  C12Q2600/154 ,  C12Q2600/158 ,  C12Q2600/16 ,  G01N33/57434 ,  G01N2800/60

摘要： Particular aspects provide novel methods and compositions (e.g., nucleic acids, kits, etc.) having substantial utility for providing a prognosis of prostate cell proliferative disorders. In particular aspects, this is achieved by the analysis of the expression status of a panel of genes, or subsets thereof.