公开(公告)号：EP1554407A2

公开(公告)日：2005-07-20

申请号：EP03808704.5

申请日：2003-10-01

申请人： Epigenomics AG

发明人： FOEKENS, John ,  HARBECK, Nadia ,  KÖNIG, Thomas ,  MAIER, Sabine ,  MARTENS, John ,  MODEL, Fabian ,  NIMMRICH, Inko ,  RUJAN, Tamas ,  SCHMITT, Armin ,  SCHMITT, Manfred ,  LOOK, Maxime, P. ,  MARX, Almuth ,  HÖFLER, Heinz

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/154 ,  C12Q2600/158 ,  C12Q2600/16

摘要： The present invention relates to modified and genomic sequences, to oligonucleotides and/or PNA-oligomers for detecting the cytosine methylation state of genomic DNA, as well as to a method for predicting the response of a subject with a cell proliferative disorder of the breast tissues, to endocrine treatment.

公开(公告)号：EP1554407B1

公开(公告)日：2009-07-29

申请号：EP03808704.5

申请日：2003-10-01

申请人： Epigenomics AG

发明人： FOEKENS, John ,  HARBECK, Nadia ,  KÖNIG, Thomas ,  MAIER, Sabine ,  MARTENS, John ,  MODEL, Fabian ,  NIMMRICH, Inko ,  RUJAN, Tamas ,  SCHMITT, Armin ,  SCHMITT, Manfred ,  LOOK, Maxime, P. ,  MARX, Almuth ,  HÖFLER, Heinz

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/154 ,  C12Q2600/158 ,  C12Q2600/16

摘要： The present invention relates to modified and genomic sequences, to oligonucleotides and/or PNA-oligomers for detecting the cytosine methylation state of genomic DNA, as well as to a method for predicting the response of a subject with a cell proliferative disorder of the breast tissues, to endocrine treatment.

公开(公告)号：EP1945806B1

公开(公告)日：2013-02-27

申请号：EP06805804.9

申请日：2006-09-21

申请人： Epigenomics AG

发明人： FOEKENS, John ,  MARTENS, John ,  EPPENBERGER-CASTORI, Serenella ,  VUAROQUEAUX, Vincent ,  SPYRATOS, Frédérique ,  HARBECK, Nadia ,  SCHMITT, Manfred ,  HÖFLER, Heinz ,  MAIER, Sabine ,  WEISS, Gunter ,  LESCHE, Ralf ,  HILDMANN, Thomas ,  PLUM, Achim

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/118 ,  C12Q2600/154 ,  C12Q2600/156 ,  C12Q2600/16

公开(公告)号：EP1692316A2

公开(公告)日：2006-08-23

申请号：EP04820431.7

申请日：2004-12-13

申请人： Epigenomics AG

发明人： FOEKENS, John ,  HARBECK, Nadia ,  KÖNIG, Thomas ,  MAIER, Sabine ,  MARTENS, John ,  MODEL, Fabian ,  NIMMRICH, Inko ,  SCHMITT, Manfred ,  LESCHE, Ralf ,  DIETRICH, Dimo ,  MÜLLER, Volkmar Department of Genecology, ,  KLUTH, Antje ,  SCHWOPE, Ina ,  HARTMANN, Oliver ,  ADORJAN, Peter ,  MARX, Almuth ,  HÖFLER, Heinz

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/118 ,  C12Q2600/154 ,  C12Q2600/158 ,  C12Q2600/16

摘要： The present invention relates to modified and genomic sequences, to oligonucleotides and/or PNA-oligomers for detecting the cytosine methylation state of genomic DNA, as well as to a method for predicting the disease free survival and/or response of a subject with a cell prolif­erative disorder of the breast tissues, to endocrine treatment.

公开(公告)号：EP1945806A1

公开(公告)日：2008-07-23

申请号：EP06805804.9

申请日：2006-09-21

申请人： Epigenomics AG

发明人： FOEKENS, John ,  MARTENS, John ,  EPPENBERGER-CASTORI, Serenella ,  VUAROQUEAUX, Vincent ,  SPYRATOS, Frédérique ,  HARBECK, Nadia ,  SCHMITT, Manfred ,  HÖFLER, Heinz ,  MAIER, Sabine ,  WEISS, Gunter ,  LESCHE, Ralf ,  HILDMANN, Thomas ,  PLUM, Achim

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/118 ,  C12Q2600/154 ,  C12Q2600/156 ,  C12Q2600/16

摘要： The present invention relates to methods for predicting the outcome of anthracycline treatment of cell proliferative disorder patients. This is achieved by determining the expression level of at least one gene selected from the group consisting of PITX2; TFFl and PLAU. The invention also relates to sequences, oligonucleotides and antibodies which can be used within the described methods.