-
公开(公告)号：EP1945806A1
公开(公告)日：2008-07-23
申请号：EP06805804.9
申请日：2006-09-21
申请人： Epigenomics AG
发明人： FOEKENS, John , MARTENS, John , EPPENBERGER-CASTORI, Serenella , VUAROQUEAUX, Vincent , SPYRATOS, Frédérique , HARBECK, Nadia , SCHMITT, Manfred , HÖFLER, Heinz , MAIER, Sabine , WEISS, Gunter , LESCHE, Ralf , HILDMANN, Thomas , PLUM, Achim
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/118 , C12Q2600/154 , C12Q2600/156 , C12Q2600/16
摘要： The present invention relates to methods for predicting the outcome of anthracycline treatment of cell proliferative disorder patients. This is achieved by determining the expression level of at least one gene selected from the group consisting of PITX2; TFFl and PLAU. The invention also relates to sequences, oligonucleotides and antibodies which can be used within the described methods.
-
2.发明公开
公开(公告)号：EP1554407A2
公开(公告)日：2005-07-20
申请号：EP03808704.5
申请日：2003-10-01
申请人： Epigenomics AG
发明人： FOEKENS, John , HARBECK, Nadia , KÖNIG, Thomas , MAIER, Sabine , MARTENS, John , MODEL, Fabian , NIMMRICH, Inko , RUJAN, Tamas , SCHMITT, Armin , SCHMITT, Manfred , LOOK, Maxime, P. , MARX, Almuth , HÖFLER, Heinz
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/154 , C12Q2600/158 , C12Q2600/16
摘要： The present invention relates to modified and genomic sequences, to oligonucleotides and/or PNA-oligomers for detecting the cytosine methylation state of genomic DNA, as well as to a method for predicting the response of a subject with a cell proliferative disorder of the breast tissues, to endocrine treatment.
-
3.发明公开METHOD AND NUCLEIC ACIDS FOR THE ANALYSIS OF A LUNG CELL PROLIFERATIVE DISORDER 审中-公开方法和核酸用于分析肺细胞增殖性疾病
公开(公告)号：EP1458893A2
公开(公告)日：2004-09-22
申请号：EP02798327.9
申请日：2002-12-10
申请人： Epigenomics AG
发明人： BURGER, Matthias , FIELD, John, K. , GENC, Bülent , LILOGLOU, Triantafillos , BECKER, Evelyne , MAIER, Sabine , NIMMRICH, Inko
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q1/6827 , C12Q2600/112 , C12Q2600/154 , C12Q2600/16 , C12Q2531/113 , C12Q2523/125 , C12Q2521/331 , C12Q2565/627
摘要： The present invention relates to modified and genomic sequences, to oligonucleotides and/or PNA-oligomers for detecting the cytosine methylation state of genomic DNA, as well as to a method for ascertaining genetic and/or epigenetic parameters of genes for use in the differentiation, diagnosis, treatment and/or monitoring of lung cell proliferative disorders, or the predisposition to lung cell proliferative disorders.
-
4.发明公开METHOD AND NUCLEIC ACIDS FOR THE ANALYSIS OF A LYMPHOID CELL PROLIFERATIVE DISORDER 审中-公开方法和核酸分析淋巴细胞的增殖性疾病
公开(公告)号：EP1451354A2
公开(公告)日：2004-09-01
申请号：EP02787817.2
申请日：2002-11-25
申请人： Epigenomics AG
发明人： BURGER, Matthias , CALDWELL, Charles , GENC, Bülent , BECKER, Evelyne , MAIER, Sabine , NIMMRICH, Inko
IPC分类号： C12Q1/68
CPC分类号： C12Q1/683 , C12Q1/6827 , C12Q1/6837 , C12Q1/6886 , C12Q2600/156 , C12Q2523/125 , C12Q2521/331 , C12Q2525/107
摘要： The present invention relates to modified and genomic sequences, to oligonucleotides and/or PNA-oligomers for detecting the cytosine methylation state of genomic DNA, as well as to a method for ascertaining genetic and/or epigenetic parameters of genes for use in the differentiation, diagnosis, treatment and/or monitoring of lymphoid cell proliferative disorders, or the predisposition to lymphoid cell proliferative disorders.
-
5.发明公开METHOD AND NUCLEIC ACIDS FOR THE IMPROVED TREATMENT OF BREAST CELL PROLIFERATIVE DISORDERS 审中-公开方法和核酸为问题的乳腺细胞增殖更好的治疗
公开(公告)号：EP1692316A2
公开(公告)日：2006-08-23
申请号：EP04820431.7
申请日：2004-12-13
申请人： Epigenomics AG
发明人： FOEKENS, John , HARBECK, Nadia , KÖNIG, Thomas , MAIER, Sabine , MARTENS, John , MODEL, Fabian , NIMMRICH, Inko , SCHMITT, Manfred , LESCHE, Ralf , DIETRICH, Dimo , MÜLLER, Volkmar Department of Genecology, , KLUTH, Antje , SCHWOPE, Ina , HARTMANN, Oliver , ADORJAN, Peter , MARX, Almuth , HÖFLER, Heinz
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/118 , C12Q2600/154 , C12Q2600/158 , C12Q2600/16
摘要： The present invention relates to modified and genomic sequences, to oligonucleotides and/or PNA-oligomers for detecting the cytosine methylation state of genomic DNA, as well as to a method for predicting the disease free survival and/or response of a subject with a cell proliferative disorder of the breast tissues, to endocrine treatment.
-
6.发明公开
公开(公告)号：EP1478778A2
公开(公告)日：2004-11-24
申请号：EP03714760.0
申请日：2003-02-27
申请人： Epigenomics AG
发明人： ADORJAN, Peter , BURGER, Matthias , MAIER, Sabine , NIMMRICH, Inko , BECKER, Evelyne , LESCHE, Ralf , RUJAN, Tamas , SCHMITT, Armin
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/154 , Y10T436/143333
摘要： The present invention relates to modified and genomic sequences, to oligonucleotides and/or PNA-oligomers for detecting the cytosine methylation state of genomic DNA, as well as to a method for ascertaining genetic and/or epigenetic parameters of genes for use in the differentiation, diagnosis, treatment and/or monitoring of colon cell proliferative disorders, or the predisposition to colon cell proliferative disorders.
-
7.发明公开METHODS AND NUCLEIC ACIDS FOR THE ANALYSIS OF HEMATOPOIETIC CELL PROLIFERATIVE DISORDERS 审中-公开方法和核酸分析造血细胞增殖性疾病
公开(公告)号：EP1399589A2
公开(公告)日：2004-03-24
申请号：EP02726213.8
申请日：2002-03-26
申请人： Epigenomics AG
发明人： ADJORAN, Peter , LESCHE, Ralf , BECKER, Evelyne , MAIER, Sabine , MODEL, Fabian , NIMMRICH, Inko
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/112 , C12Q2600/154 , C12Q2600/158 , C12Q2600/16 , Y02A90/24 , Y02A90/26
摘要： The present invention provides methods and computer program products for epigenetic feature selection. The invention enables the selection of relevant epigenetic features prior to further data analysis. The invention is preferably used for interpretation of large scale DNA methylation analysis data.
-
公开(公告)号：EP1945806B1
公开(公告)日：2013-02-27
申请号：EP06805804.9
申请日：2006-09-21
申请人： Epigenomics AG
发明人： FOEKENS, John , MARTENS, John , EPPENBERGER-CASTORI, Serenella , VUAROQUEAUX, Vincent , SPYRATOS, Frédérique , HARBECK, Nadia , SCHMITT, Manfred , HÖFLER, Heinz , MAIER, Sabine , WEISS, Gunter , LESCHE, Ralf , HILDMANN, Thomas , PLUM, Achim
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/118 , C12Q2600/154 , C12Q2600/156 , C12Q2600/16
-
9.发明授权
公开(公告)号：EP1481095B1
公开(公告)日：2010-12-08
申请号：EP03742964.4
申请日：2003-02-27
申请人： Epigenomics AG
发明人： ADORJAN, Peter , BURGER, Matthias , MAIER, Sabine , LESCHE, Ralf , COTTRELL, Susan , MOONEY, Suzanne
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/154 , Y10T436/143333
摘要： The present invention relates to modified and genomic sequences, to oligonucleotides and/or PNA-oligomers for detecting the cytosine methylation state of genomic DNA, as well as to a method for ascertaining genetic and/or epigenetic parameters of genes for use in the differentiation, diagnosis, treatment and/or monitoring of colon cell proliferative disorders, or the predisposition to colon cell proliferative disorders.
-
10.发明授权METHOD AND NUCLEIC ACIDS FOR THE ANALYSIS OF COLORECTAL CELL PROLIFERATIVE DISORDERS 有权防扩散结肠直肠细胞问题方法和核酸分析
公开(公告)号：EP1478784B1
公开(公告)日：2007-10-24
申请号：EP03742934.7
申请日：2003-02-13
申请人： Epigenomics AG
发明人： ADORJAN, Peter , BURGER, Matthias , MAIER, Sabine , LESCHE, Ralf , COTTRELL, Susan , DE VOS, Theo
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/154 , Y10T436/143333
摘要： The present invention relates to modified and genomic sequences, to oligonucleotides and/or PNA-oligomers for detecting the cytosine methylation state of genomic DNA, as well as to a method for ascertaining genetic and/or epigenetic parameters of genes for use in the differentiation, diagnosis, treatment and/or monitoring of colon cell proliferative disorders, or the predisposition to colon cell proliferative disorders.
-
-
-
-
-
-
-
-
-
搜索结果
16 条记录 (耗时 0.197 秒)
