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1.发明授权ARYL SUBSTITUTED PYRIDINES, PYRIMIDINES, PYRAZINES AND TRIAZINES AND THE USE THEREOF 有权芳基取代的吡啶，嘧啶，吡嗪和三嗪及其使用
公开(公告)号：EP1265866B1
公开(公告)日：2010-07-21
申请号：EP01918558.6
申请日：2001-03-12
申请人： Euro-Celtique S.A.
发明人： HOGENKAMP, Derk, J. , NGUYEN, Phong , SHAO, Bin
IPC分类号： C07D213/81 , C07D239/28 , C07D239/38 , C07D251/24 , C07D241/24 , C07D403/04 , A61K31/505 , A61P25/08
CPC分类号： C07D213/81 , C07D239/28 , C07D239/38 , C07D241/24 , C07D251/24 , C07D403/04
摘要： This invention relates aryl substituted pyridines, pyrimides, pyrazines and triazines of Formula (I): or a pharmaceutically acceptable salt, prodrug or solvate thereof, wherein A1, A2, A3, R1-R4, X and Y are set in the specification. The invention is also directed to the use of compounds of Formula I for the treatment of neuronal damage following global and focal ischemia, for the treatment or prevention of neurodegenerative conditions such as amyotrophic lateral sclerosis (ALS), and for the treatment, prevention or amelioration of both acute or chronic pain, as antitinnitus agents, as anticonvulsants, and as antimanic depressants, as local anesthetics, as antiarrhytmics and for the treatment of prevention of diabetic neuropathy.
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2.发明授权ARYL SUBSTITUTED PYRAZOLES, TRIAZOLES AND TETRAZOLES AS SODIUM CHANNEL BLOCKER 有权芳基取代的吡唑，三唑和四唑AS钠通道阻滞剂
公开(公告)号：EP1292577B1
公开(公告)日：2012-10-24
申请号：EP01918874.7
申请日：2001-03-22
申请人： Euro-Celtique S.A.
发明人： HOGENKAMP, Derk , NGUYEN, Phong , YANG, Ji
IPC分类号： C07D231/12 , C07D249/08 , A61K31/4196 , A61K31/415 , A61P23/00 , A61P25/08
CPC分类号： C07D231/12 , C07D233/56 , C07D249/08
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3.发明授权ARYL SUBSTITUTED PYRAZOLES, IMIDAZOLES, OXAZOLES, THIAZOLES AND PYRROLES, AND THE USE THEREOF 有权芳基取代的吡唑，咪唑，恶唑，噻唑和吡咯，及其用途
公开(公告)号：EP1173169B1
公开(公告)日：2010-05-12
申请号：EP00919636.1
申请日：2000-03-24
申请人： Euro-Celtique S.A.
IPC分类号： C07D231/10 , C07D207/30 , C07D233/54 , A61K31/40 , A61K31/415 , A61K31/421 , A61K31/426 , A61K31/496 , A61K31/506 , A61K31/4164 , A61K31/5377 , A61P25/00
CPC分类号： C07D207/416 , C07D231/12 , C07D233/54 , C07D233/64 , C07D235/18 , C07D263/34 , C07D277/56 , C07D403/04
摘要： This invention relates to compounds having Formula (I) or a pharmaceutically acceptable salt, prodrug or solvate thereof, wherein Het and R5-R13 are set in the specification. The invention also is directed to the use of compounds of Formula (I) for the treatment of neuronal damage following global and focal ischemia, for the treatment or prevention of neurodegenerative conditions such as amyotrophic lateral sclerosis (ALS), and for the treatment, prevention or amelioration of both acute or chronic pain, as antitinnitus agents, as anticonvulsants, and as antimanic depressants, as local anesthetics, as antiarrhythmics and for the treatment or prevention of diabetic neuropathy.
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4.发明公开ARYL SUBSTITUTED PYRAZOLES, TRIAZOLES AND TETRAZOLES AS SODIUM CHANNEL BLOCKER 有权芳基取代的吡唑，三唑和四唑AS钠通道阻滞剂
公开(公告)号：EP1292577A2
公开(公告)日：2003-03-19
申请号：EP01918874.7
申请日：2001-03-22
申请人： Euro-Celtique S.A.
发明人： HOGENKAMP, Derk , NGUYEN, Phong , YANG, Ji
IPC分类号： C07D231/12 , C07D249/08 , A61K31/4196 , A61K31/415 , A61P23/00 , A61P25/08
CPC分类号： C07D231/12 , C07D233/56 , C07D249/08
摘要： This invention relates to compounds having the Formula (I) or a pharmaceutically acceptable salt, prodrug or solvate thereof, wherein Het and R5 - R8 are set in the specification. The invention also is directed to the use of compounds of Formula (I) for the treatment of neuronal damage following global and focal ischemia, for the treatment or prevention of neurodegenerative conditions such as amyotrophic lateral sclerosis (ALS), and for the treatment, prevention or amelioration of both acute or chronic pain, as antitinnitus agents, as anticonvulsants, and as antimanic depressants, as local anesthetics, as antiarrhythmics and for the treatment or prevention of diabetic neuropathy.
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5.发明公开ARYL SUBSTITUTED PYRAZOLES, IMIDAZOLES, OXAZOLES, THIAZOLES AND PYRROLES, AND THE USE THEREOF 有权芳基取代的吡唑，咪唑，恶唑，噻唑和吡咯，及其用途
公开(公告)号：EP1173169A1
公开(公告)日：2002-01-23
申请号：EP00919636.1
申请日：2000-03-24
申请人： Euro-Celtique S.A.
IPC分类号： A61K31/40 , A61K31/415 , A61K31/421 , A61K31/426 , A61K31/496 , A61K31/506 , A61K31/4164 , A61K31/5377 , C07D207/30 , C07D231/10 , C07D233/54 , C07D403/00 , C07D413/00
CPC分类号： C07D207/416 , C07D231/12 , C07D233/54 , C07D233/64 , C07D235/18 , C07D263/34 , C07D277/56 , C07D403/04
摘要： This invention relates to compounds having Formula (I) or a pharmaceutically acceptable salt, prodrug or solvate thereof, wherein Het and R5-R13 are set in the specification. The invention also is directed to the use of compounds of Formula (I) for the treatment of neuronal damage following global and focal ischemia, for the treatment or prevention of neurodegenerative conditions such as amyotrophic lateral sclerosis (ALS), and for the treatment, prevention or amelioration of both acute or chronic pain, as antitinnitus agents, as anticonvulsants, and as antimanic depressants, as local anesthetics, as antiarrhythmics and for the treatment or prevention of diabetic neuropathy.
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6.发明公开ARYL SUBSTITUTED PYRIDINES, PYRIMIDINES, PYRAZINES AND TRIAZINES AND THE USE THEREOF 有权芳基取代的吡啶，嘧啶，吡嗪和三嗪及其使用
公开(公告)号：EP1265866A2
公开(公告)日：2002-12-18
申请号：EP01918558.6
申请日：2001-03-12
发明人： HOGENKAMP, Derk, J. , NGUYEN, Phong , SHAO, Bin
IPC分类号： C07D213/81 , C07D239/28 , C07D239/38 , C07D251/24 , C07D241/24 , C07D403/04 , A61K31/505 , A61P25/08
CPC分类号： C07D213/81 , C07D239/28 , C07D239/38 , C07D241/24 , C07D251/24 , C07D403/04
摘要： This invention relates aryl substituted pyridines, pyrimides, pyrazines and triazines of Formula (I): or a pharmaceutically acceptable salt, prodrug or solvate thereof, wherein A1, A2, A3, R1-R4, X and Y are set in the specification. The invention is also directed to the use of compounds of Formula I for the treatment of neuronal damage following global and focal ischemia, for the treatment or prevention of neurodegenerative conditions such as amyotrophic lateral sclerosis (ALS), and for the treatment, prevention or amelioration of both acute or chronic pain, as antitinnitus agents, as anticonvulsants, and as antimanic depressants, as local anesthetics, as antiarrhytmics and for the treatment of prevention of diabetic neuropathy.
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