公开(公告)号：EP1910308A1

公开(公告)日：2008-04-16

申请号：EP06785562.7

申请日：2006-06-26

申请人： Exelixis, Inc.

发明人： BUSCH, Brett B. ,  FLATT, Brenton T. ,  GU, Xiao-Hui ,  LU, Shao-Po ,  MARTIN, Richard ,  MOHAN, Raju ,  NYMAN, Michael Charles ,  SCHWEIGER, Edwin ,  STEVENS, William C., Jr. ,  WANG, Tie-Lin ,  XIE, Yinong

IPC分类号： C07D233/54 ,  C07D409/04 ,  C07D401/04 ,  A61K31/4164 ,  A61P3/10

CPC分类号： C07D233/64 ,  C07D231/12 ,  C07D231/22 ,  C07D233/90 ,  C07D401/04 ,  C07D401/10 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/10 ,  C07D403/12 ,  C07D403/14 ,  C07D405/10 ,  C07D405/12 ,  C07D405/14 ,  C07D409/04 ,  C07D409/10 ,  C07D409/12 ,  C07D409/14 ,  C07D413/12 ,  C07D417/10 ,  C07D417/12 ,  C07D417/14 ,  C07D487/08

摘要： Compounds of the invention, such as compounds of Formulae IIa, IIb, IIc or IId, and pharmaceutically acceptable salts, isomers, and prodrugs thereof, are useful as modulators of the activity of liver X receptors, where R1, R2, R21, R3 and G are defined herein. Pharmaceutical compositions containing the compounds and methods of using the compounds are also disclosed.

公开(公告)号：EP2121621A1

公开(公告)日：2009-11-25

申请号：EP07865385.4

申请日：2007-12-07

申请人： Exelixis, Inc.

发明人： BOREN, Brant Clayton ,  BUSCH, Brett B. ,  GU, Xiao-hui ,  JAMMALAMADAKA, Vasu ,  LU, Shao-Po ,  MARTIN, Richard ,  MOHAN, Raju ,  SCHWEIGER, Edwin ,  STEVENS, William C. Jr. ,  WANG, Tie-lin ,  XIE, Yinong ,  XU, Wei

IPC分类号： C07D233/90 ,  C07D231/10 ,  A61K31/415 ,  A61K31/4164 ,  A61P3/10

CPC分类号： C07D233/90 ,  C07D231/10

摘要： Compounds of the invention are disclosed, such as compounds of formulae LX - LXIV, and pharmaceutically acceptable salts, isomers, or prodrugs thereof, which are useful as modulators of the activity of liver X receptors (LXR) and Farnesoid X receptors (FXR), where R00, R200, R400, R500, J11, J21, G1, G21, and Q are defined herein. Pharmaceutical compositions containing the compounds and methods of using the compounds are also disclosed.