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公开(公告)号:EP2074114A1
公开(公告)日:2009-07-01
申请号:EP08767429.7
申请日:2008-04-24
申请人: Exelixis, Inc.
发明人: KOLTUN, Elena S. , KEARNEY, Patrick , AAY, Naing , ARCALAS, Arlyn , CHAN, Wai Ki Vicky , CURTIS, Jeffry Kimo , DU, Hongwang , HUANG, Ping , KANE, Brian , KIM, Moon Hwan , PACK, Michael , TSUHAKO, Amy L. , XU, Wei , ZAHARIA, Cristiana A. , ZHOU, Peiwen
IPC分类号: C07D403/04 , C07D405/04 , C07D413/04 , C07D417/04 , A61K31/513 , A61P35/00
CPC分类号: C07D405/04 , C07D403/04 , C07D413/04 , C07D417/04
摘要: A compound having Formula I :or a pharmaceutically acceptable salt thereof, wherein X, R, R and R are as defined in the specification; pharmaceutical compositions thereof; and methods of use thereof. The compounds of Fomula I are inhibitors of Casein kinase II (CK2) pathways.
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公开(公告)号:EP2074103A1
公开(公告)日:2009-07-01
申请号:EP08743264.7
申请日:2008-04-25
申请人: Exelixis, Inc. , Koltun, Elena S.
发明人: KOLTUN, Elena S. , TSUHAKO, Amy L. , AAY, Naing , BROWN, S. David , CHAN, Wai Ki Vicky , DU, Hongwang , HUANG, Ping , KANE, Brian , KEARNEY, Patrick , KIM, Moon Hwan , PACK, Michael , XU, Wei , ZHOU, Peiwen
IPC分类号: C07D239/36 , C07D403/12 , C07D413/04 , C07D409/04 , C07D407/12 , C07D409/12 , A61K31/513 , A61P35/00 , C07D213/64
CPC分类号: C07D213/64 , C07D239/36 , C07D401/12 , C07D403/12 , C07D405/12 , C07D407/12 , C07D409/04 , C07D409/12 , C07D413/04
摘要: A compound having Formula I or II (Formula I) or (Formula II), or a pharmaceutically acceptable salt thereof, wherein X, Z, R1, R2, R11 and R12 are as defined in the specification; pharmaceutical compositions thereof; and methods of use thereof.
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公开(公告)号:EP2074114B1
公开(公告)日:2013-03-06
申请号:EP08767429.7
申请日:2008-04-24
申请人: Exelixis, Inc.
发明人: KOLTUN, Elena S. , KEARNEY, Patrick , AAY, Naing , ARCALAS, Arlyn , CHAN, Wai Ki Vicky , CURTIS, Jeffry Kimo , DU, Hongwang , HUANG, Ping , KANE, Brian , KIM, Moon Hwan , PACK, Michael , TSUHAKO, Amy L. , XU, Wei , ZAHARIA, Cristiana A. , ZHOU, Peiwen
IPC分类号: C07D403/04 , C07D405/04 , C07D413/04 , C07D417/04 , A61K31/513 , A61P35/00
CPC分类号: C07D405/04 , C07D403/04 , C07D413/04 , C07D417/04
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