公开(公告)号：EP2074103A1

公开(公告)日：2009-07-01

申请号：EP08743264.7

申请日：2008-04-25

申请人： Exelixis, Inc. ,  Koltun, Elena S.

发明人： KOLTUN, Elena S. ,  TSUHAKO, Amy L. ,  AAY, Naing ,  BROWN, S. David ,  CHAN, Wai Ki Vicky ,  DU, Hongwang ,  HUANG, Ping ,  KANE, Brian ,  KEARNEY, Patrick ,  KIM, Moon Hwan ,  PACK, Michael ,  XU, Wei ,  ZHOU, Peiwen

IPC分类号： C07D239/36 ,  C07D403/12 ,  C07D413/04 ,  C07D409/04 ,  C07D407/12 ,  C07D409/12 ,  A61K31/513 ,  A61P35/00 ,  C07D213/64

CPC分类号： C07D213/64 ,  C07D239/36 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D407/12 ,  C07D409/04 ,  C07D409/12 ,  C07D413/04

摘要： A compound having Formula I or II (Formula I) or (Formula II), or a pharmaceutically acceptable salt thereof, wherein X, Z, R1, R2, R11 and R12 are as defined in the specification; pharmaceutical compositions thereof; and methods of use thereof.

公开(公告)号：EP3743417A1

公开(公告)日：2020-12-02

申请号：EP19709144.0

申请日：2019-01-25

申请人： Exelixis, Inc.

发明人： BANNEN, Lynne Canne ,  BUI, Minna ,  JIANG, Faming ,  WANG, Yong ,  XU, Wei

IPC分类号： C07D401/14 ,  C07D413/14 ,  A61K31/4375 ,  A61K31/4427 ,  C07D401/12 ,  C07D471/04 ,  C07D491/147 ,  A61P35/00

公开(公告)号：EP1848719A1

公开(公告)日：2007-10-31

申请号：EP05855490.8

申请日：2005-12-27

申请人： Exelixis, Inc.

发明人： RICE, Kenneth, D. ,  CO, Erick, Wang ,  KIM, Moon, Hwan ,  BANNEN, Lynn, Canne ,  BUSSENIUS, Joerg ,  LE, Donna ,  TSUHAKO, Amy, Lew ,  NUSS, John ,  WANG, Yong ,  XU, Wei ,  KLEIN, Rhett, Ronald

IPC分类号： C07D487/04 ,  A61K31/519 ,  A61P35/00 ,  A61P29/00 ,  A61P37/00

CPC分类号： C07D487/04

摘要： The invention provides compounds of formula (I) and methods for inhibition of kinases, more specifically p70S6 kinases, and more preferably p70S6, Akt-1 and Akt-2 kinases. The invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration, chemoinvasion and metabolism. Compounds of the invention inhibit, regulate and/or modulate kinase receptor signal transduction pathways related to the changes in cellular activities as mentioned above, and the invention includes compositions which contain these compounds, and methods of using them to treat kinase-dependent diseases and conditions.

公开(公告)号：EP1773826A2

公开(公告)日：2007-04-18

申请号：EP05763620.1

申请日：2005-07-01

申请人： Exelixis, Inc.

发明人： BANNEN, Lynne Canne ,  CHAN, Diva Sze-Ming ,  DALRYMPLE, Lisa Esther ,  JAMMALAMADAKA, Vasu ,  KHOURY, Richard George ,  LEAHY, James William ,  MAC, Morrison B. ,  MANN, Grace ,  MANN, Larry W. ,  NUSS, John M. ,  PARKS, Jason Jevious ,  WANG, Yong ,  XU, Wei

IPC分类号： C07D417/04 ,  C07D487/04 ,  C07D473/06 ,  C07D473/10 ,  C07D473/22 ,  C07D473/24 ,  C07D473/30 ,  C07D473/34 ,  C07D473/38 ,  C07D473/40 ,  C07D491/04 ,  C07D495/04 ,  A61K31/52 ,  A61K31/522 ,  A61K31/519 ,  A61K31/437 ,  A61K31/4365 ,  A61K31/4355 ,  A61P35/00

CPC分类号： C07D487/04 ,  C07D209/52 ,  C07D471/04 ,  C07D473/30 ,  C07D473/32 ,  C07D493/04 ,  C07D493/14 ,  C07D493/20 ,  C07D498/04

摘要： The present invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. More specifically, the invention provides appropriately functionalized 5,6-fused bicyclics which inhibit, regulate and/or modulate kinase receptor, particularly c-Met, KDR, and flt-3, signal transduction pathways related to the changes in cellular activities as mentioned above, compositions which contain these compounds, and methods of using them to treat kinase-dependent diseases and conditions.

公开(公告)号：EP1608373A2

公开(公告)日：2005-12-28

申请号：EP04757665.7

申请日：2004-03-19

申请人： Exelixis Inc.

发明人： PARKS, Jason Jevious ,  BANNEN, Lynne Canne ,  BROWN, S. David ,  CHENG, Wei ,  CHEUNG, Atwood Kim ,  DALRYMPLE, Lisa Esther ,  EPSHTEYN, Sergey ,  IBRAHIM, Mohamed Abdulkader ,  JAMMALAMADAKA, Vasu ,  LEAHY, James William ,  LEWIS, Gary Lee ,  MAC, Morrison B. ,  MANN, Larry W. ,  NUSS, John M. ,  NOGUCHI, Robin Tammie ,  RIDGWAY, Brian Hugh ,  SANGALANG, Joan C. ,  SCHNEPP, Kevin Luke ,  SHI, Xian ,  WILLIAMS, Matthew A. ,  XU, Wei ,  KHOURY, Richard

IPC分类号： A61K31/496 ,  C07D417/04 ,  C07D417/14

CPC分类号： A61K31/496 ,  C07D213/75 ,  C07D239/42 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D417/12 ,  C07D417/14

摘要： The present invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. Compounds of the invention inhibit, regulate and/or modulate kinases, particularly Tie-2. Methods of using the compounds and pharmaceutical compositions thereof to treat kinase-dependent diseases and conditions are also an aspect of the invention.

公开(公告)号：EP4110779A1

公开(公告)日：2023-01-04

申请号：EP21712651.5

申请日：2021-02-23

申请人： Exelixis, Inc.

发明人： BANNEN, Lynne ,  XU, Wei ,  WANG, Yong ,  RAUB, Andrew ,  SPANGLER, Benjamin ,  SALVANT, Justin ,  TSO, Kin ,  JIANG, Faming

IPC分类号： C07D471/04 ,  C07D401/14 ,  C07D405/14 ,  A61P35/00 ,  A61K31/4375

公开(公告)号：EP4034532A1

公开(公告)日：2022-08-03

申请号：EP20789784.4

申请日：2020-09-25

申请人： Exelixis, Inc.

发明人： BANNEN, Lynne ,  BUI, Minna ,  JIANG, Faming ,  MAUNG, Jack ,  RAUB, Andrew ,  SALVANT, Justin ,  SPANGLER, Benjamin ,  TSO, Kin ,  WANG, Yong ,  XU, Wei

IPC分类号： C07D401/12 ,  C07D471/04 ,  A61P35/00 ,  A61K31/4375

公开(公告)号：EP3914356A1

公开(公告)日：2021-12-01

申请号：EP20709372.5

申请日：2020-01-24

申请人： Exelixis, Inc.

发明人： BANNEN, Lynne, Canne ,  JIANG, Faming ,  TSO, Kin ,  XU, Wei

IPC分类号： A61P35/00 ,  A61K31/4375 ,  A61K31/47 ,  C07D215/22 ,  C07D215/48 ,  C07D401/12 ,  C07D471/04

公开(公告)号：EP3743070A1

公开(公告)日：2020-12-02

申请号：EP19704970.3

申请日：2019-01-25

申请人： Exelixis, Inc.

发明人： BANNEN, Lynne, Canne ,  BUI, Minna ,  JIANG, Faming ,  TSO, Kin ,  WANG, Yong ,  XU, Wei

IPC分类号： A61K31/47 ,  A61K31/4709 ,  C07D215/22 ,  C07D401/04 ,  C07D401/06 ,  C07D401/12 ,  C07D405/04 ,  C07D405/12 ,  C07D413/04 ,  C07D413/12 ,  A61P35/00

公开(公告)号：EP1673085B1

公开(公告)日：2011-11-09

申请号：EP04789057.9

申请日：2004-09-24

申请人： Exelixis, Inc.

发明人： BANNEN, Lynne Canne ,  CHAN, Diva Sze-Ming ,  CHEN, Jeff ,  DALRYMPLE, Lisa Esther ,  FORSYTH, Timothy Patrick ,  HUYNH, Tai Phat ,  JAMMALAMADAKA, Vasu ,  KHOURY, Richard George ,  LEAHY, James William ,  MAC, Morrison B. ,  MANN, Grace ,  MANN, Larry W. ,  NUSS, John M. ,  PARKS, Jason Jevious ,  TAKEUCHI, Craig Stacy ,  WANG, Yong ,  XU, Wei

IPC分类号： C07D417/12 ,  A61K31/47 ,  A61K31/535 ,  C07D413/00 ,  C07D215/16 ,  C07D215/20 ,  C07D239/88 ,  C07D401/12 ,  A61P35/00

CPC分类号： C07D215/233 ,  A61K31/47 ,  A61K31/4709 ,  A61K31/4725 ,  A61K31/496 ,  A61K31/501 ,  A61K31/505 ,  A61K31/506 ,  A61K31/517 ,  A61K31/5377 ,  C07D215/22 ,  C07D215/36 ,  C07D215/38 ,  C07D215/46 ,  C07D239/88 ,  C07D239/94 ,  C07D295/15 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/14 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C12Q1/485 ,  G01N2500/04 ,  Y02A50/393

摘要： The present invention provides a compound which is represented by the following structure: which inhibits, regulates and/or modulates kinase receptors, particularly c-Met, KDR, c-Kit, flt-3 and flt-4. This compound is therefore suitable for the treatment of diseases or disorders associated with uncontrolled, abnormal and/or unwanted cellular activities.