公开(公告)号：EP1903021A4

公开(公告)日：2010-06-09

申请号：EP06729640

申请日：2006-03-22

Applicant: TOSOH F TECH INC

Inventor： KONDO NORIHISA ,  WATANABE AKIO ,  KANEZAKI HIROKI ,  KAWADA KOSUKE

IPC: C07C17/16 ,  C07C19/08 ,  C07C23/08 ,  C07C23/38 ,  C07C67/307 ,  C07C69/63 ,  C07C69/65 ,  C07D207/16

CPC classification number: C07C67/307 ,  C07B39/00 ,  C07C17/16 ,  C07C2601/08 ,  C07C2603/74 ,  C07C19/08 ,  C07C23/38 ,  C07C23/08 ,  C07C69/65 ,  C07C69/63

公开(公告)号：EP1403238A4

公开(公告)日：2006-01-25

申请号：EP02738894

申请日：2002-07-01

Applicant: TOSOH F TECH INC

Inventor： MIMURA HIDEYUKI ,  KAWADA KOSUKE ,  ARAI SHOJI

IPC: C07C29/124 ,  C07C31/38 ,  C07C31/42 ,  C07C31/44 ,  C07C205/43 ,  C07C233/10 ,  C07C233/28 ,  C07C233/33 ,  C07C233/44 ,  C07C233/55 ,  C07F9/12

CPC classification number: C07C29/124 ,  C07C31/38

Abstract: A process for producing a fluorinated alcohol from a fluoroalkyl halide through a one-stage reaction in high yield with high selectivity without using a highly toxic compound such as a heavy metal compound, which is difficult to handle or treat. The process, which is for producing a fluorinated alcohol represented by the general formula (2): Rf(A)OH (2) (wherein Rf represents C1-10 perfluoroalkyl and A represents a C3-10, linear or branched, saturated hydrocarbon group), is characterized by reacting a fluoroalkyl halide represented by the general formula (1): Rf(A)X (1) (wherein Rf and A are the same as defined above and X represents halogeno) with an alkali metal salt of 4-hydroxybutyric acid in Ϝ-butyrolactone as a solvent.

公开(公告)号：EP1431269A4

公开(公告)日：2004-12-22

申请号：EP01972523

申请日：2001-09-27

Applicant: TOSOH F TECH INC

Inventor： KONDO NORIHISA ,  MIMURA HIDEYUKI ,  KAWADA KOSUKE ,  ARAI SHOJI

IPC: C07C67/54 ,  C07C69/716 ,  C07C67/307 ,  C07C67/58 ,  C07C69/72

CPC classification number: C07C67/54 ,  C07C69/716

Abstract: A method of separating a purified 2-fluoro-3-oxoalkylcarboxylic acid ester as a reaction product from a liquid reaction mixture obtained by fluorinating a 3-oxoalkylcarboxylic acid ester, characterized by comprising removing the hydrogen fluoride yielded as a by-product from the liquid reaction mixture and then separating the 2-fluoro-3-oxoalkylcarboxylic acid ester by distillation. Thus, a high-purity 2-fluoro-3-oxoalkylcarboxylic acid ester, which is useful as an intermediate for medicines and agricultural chemicals, can be separated from the liquid reaction mixture resulting from the fluorination of a 3-oxoalkylcarboxylic acid ester.

公开(公告)号：EP0891962A4

公开(公告)日：1999-09-01

申请号：EP97907369

申请日：1997-03-18

Applicant: F TECH INC

Inventor： NUKUI KAZUNORI ,  FUKAMI SHINJI ,  KAWADA KOSUKE

IPC: C07D307/33 ,  B01J27/02 ,  B01J27/12 ,  B01J31/02 ,  B01J31/04 ,  C07B39/00 ,  C07B61/00 ,  C07C45/63 ,  C07C47/14 ,  C07C49/167 ,  C07C49/185 ,  C07C49/463 ,  C07C49/80 ,  C07C67/307 ,  C07C69/716 ,  C07C69/738 ,  C07C69/757 ,  C07C205/43 ,  C07C205/45 ,  C07D211/78 ,  C07D211/86 ,  C07D309/32 ,  C07J1/00 ,  C07C49/16 ,  C07C49/227 ,  C07C49/457 ,  C07C49/687

CPC classification number: C07J1/0011 ,  C07B39/00 ,  C07C45/63 ,  C07C67/307 ,  C07C205/43 ,  C07C205/45 ,  C07C69/716 ,  C07C47/14 ,  C07C49/16 ,  C07C49/227 ,  C07C49/457 ,  C07C49/687 ,  C07C49/80 ,  C07C69/738 ,  C07C69/757

Abstract: A process for the preparation of fluorinated dicarbonyl compounds of general formula (2), comprising reacting dicarbonyl compounds of general formula (1) with fluorine gas without any solvent in the presence of one or more acids selected from among trifluoromethanesulfonic acid, methanesulfonic acid, hydrofluoric acid, sulfuric acid, trifluoroacetic acid, boron trifluoride and sulfonated polymers wherein R?1, R2 and R3¿ are each hydrogen, alkyl or the like; and R?1a, R2a and R3a¿ are each the same as defined for R?1, R2 and R3¿, or alternatively when R?1, R2 and R3¿ are each hydrogen, the hydrogen may be replaced by fluorine, while when R?1, R2 and R3¿ are each optionally substituted alkyl, one or more hydrogen atoms on the α-position carbon atom to the CO-group may be replaced by fluorine. This process can give fluorinated dicarbonyl compounds in high yields and at high selectivity.

公开(公告)号：EP1623969A4

公开(公告)日：2006-09-20

申请号：EP04723004

申请日：2004-03-24

Applicant: TOSOH F TECH INC

Inventor： TOKUHISA KENJI ,  MIMURA HIDEYUKI ,  KAWADA KOSUKE ,  ARAI SHOJI

IPC: C07C57/54 ,  C07B61/00 ,  C07C51/10 ,  C07C51/12 ,  C07C57/52

CPC classification number: C07C57/54 ,  C07C57/52

Abstract: An ±-pentafluoroethyl acrylic acid derivative represented by the general formula [I]: [wherein R represents a hydrogen atom, a non-substituted or substituted aromatic ring, or a straight or branched alkyl group having 1 to 20 carbon(s) which may have a cyclic moiety optionally substituted with at least one substituent (halogen atom, hydroxyl group, straight or branched alkoxy group having 1 to 10 carbon(s) which may have a cyclic moiety, non-substituted or substituted aromatic group)].

Abstract translation: 由通式[I]表示的α-五氟乙基丙烯酸衍生物：其中R表示氢，（未）取代的芳族环或任选具有可具有一个或多个取代基的环状部分的C1-20直链或支链烷基 在卤代，羟基，任选具有环状部分的C1-10直链或支链烷氧基和（未）取代的芳香环之中）。

公开(公告)号：EP1362842A4

公开(公告)日：2005-06-29

申请号：EP01272302

申请日：2001-12-25

Applicant: TOSOH F TECH INC

Inventor： KONDO NORIHISA ,  MIMURA HIDEYUKI ,  NUKUI KAZUNORI ,  KAWADA KOSUKE ,  ARAI SHOJI

IPC: C07C67/307 ,  C07C67/54 ,  C07C67/58 ,  C07C69/716 ,  C07C69/72 ,  C07C69/738

CPC classification number: C07C67/58 ,  C07C67/307 ,  C07C69/738 ,  C07C69/716

Abstract: A process for preparing 2-fluoro-3-oxoalkylcarboxylic acid esters by fluorinating a 3-oxoalkylcarboxylic acid ester with fluorine gas, characterized in that the concentration of the 3-oxoalkylcarboxylic acid ester in the reaction fluid is kept at 3 wt% or above; and a process for purifying 2-fluoro-3- oxoalkylcarboxylic acid esters, characterized by washing a product of fluorination of a 3-oxoalkylcarboxylic acid ester with at least thrice as much water as the substrate to thereby obtain a purified 2-fluoro-3-oxoalkylcarboxylic acid ester in a high yield. According to these processes, high-purity 2-fluoro-3-oxoalkylcarboxylic acid esters useful as intermediates for drugs or agricultural chemicals can be efficiently prepared through inhibition of by-product formation or efficient purification of products of fluorination of 3-oxoalkylcarboxylic acid esters.

Abstract translation: 其特征在于，反应液中的3-氧代烷基羧酸酯的浓度保持在3重量％以上，其特征在于，所述反应液中的3-氧代烷基羧酸酯的浓度为3重量％以上。 和纯化2-氟-3-氧代烷基羧酸酯的方法，其特征在于用至少为底物3倍的水洗涤3-氧代烷基羧酸酯的氟化产物，从而得到纯化的2-氟-3- 氧代烷基羧酸酯。 根据这些方法，通过抑制副产物形成或有效纯化3-氧代烷基羧酸酯的氟化产物，可以有效地制备用作药物或农药中间体的高纯度2-氟-3-氧代烷基羧酸酯。