公开(公告)号：EP2046831B1

公开(公告)日：2012-01-04

申请号：EP07718518.9

申请日：2007-06-26

申请人： f-star Biotechnologische Forschungs- und Entwicklungsges. m.b.H.

发明人： RÜKER, Florian ,  HIMMLER, Gottfried ,  WOZNIAK-KNOPP, Gordana

IPC分类号： C07K16/00 ,  C07K19/00 ,  C12N15/62

CPC分类号： C07K16/468 ,  C07K16/005 ,  C07K16/28 ,  C07K16/2887 ,  C07K2317/52

摘要： The present invention provides a multivalent immunoglobulin or part thereof binding specifically to at least two cell surface molecules of a single cell with at least one modification in at least one structural loop region of said immunoglobulin determining binding to an epitope of said cell surface molecules wherein the unmodified immunoglobulin does not significantly bind to said epitope, its use and methods for producing it.

公开(公告)号：EP2158220A1

公开(公告)日：2010-03-03

申请号：EP08756842.4

申请日：2008-06-26

申请人： F-Star Biotechnologische Forschungs - Und Entwicklungsges. M.B.H.

发明人： HIMMLER, Gottfried ,  RÜKER, Florian ,  WOZNIAK-KNOPP, Gordana ,  MUDDE, Geert ,  REDL, Gerda

IPC分类号： C07K16/00 ,  C40B40/10 ,  C40B40/02

CPC分类号： C07K16/005 ,  C07K16/32 ,  C07K2317/52 ,  C07K2317/569 ,  C07K2318/10 ,  C40B30/04 ,  G01N33/6857 ,  G01N2333/70535

摘要： The present invention relates to a method of preparing a genetic package displaying oligomers of modular antibody domains binding to a target and to a scaffold ligand as well as to vectors and libraries of genetic packages produced thereby. The invention further relates to methods of selecting suitable linker sequences for use in such oligomer display.

摘要翻译： 本发明涉及一种制备显示与靶标和支架配体结合的模块抗体结构域的寡聚体的遗传包装的方法，以及由此产生的遗传包装的载体和文库。 本发明还涉及选择用于这种低聚物显示的合适的接头序列的方法。