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公开(公告)号：EP3986906A1
公开(公告)日：2022-04-27
申请号：EP20734490.4
申请日：2020-06-19
发明人： EDELMANN, Martin , MUSER, Thorsten
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公开(公告)号：EP3371169B1
公开(公告)日：2019-07-17
申请号：EP16790362.4
申请日：2016-11-03
发明人： GAUFRETEAU, Delphine , HILPERT, Hans , HUMM, Roland , KOLCZEWSKI, Sabine , MUSER, Thorsten , PLANCHER, Jean-Marc , STOLL, Theodor
IPC分类号： C07D401/14 , C07D403/10 , C07D403/14 , C07D498/04 , A61K31/506 , A61K31/513 , A61K31/5383 , A61P9/00 , A61P25/00 , A61P27/00 , A61P31/04 , A61P31/12
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公开(公告)号：EP3371170B1
公开(公告)日：2019-07-31
申请号：EP16791377.1
申请日：2016-11-03
发明人： GAUFRETEAU, Delphine , HILPERT, Hans , HUMM, Roland , KOLCZEWSKI, Sabine , MUSER, Thorsten , PLANCHER, Jean-Marc , STOLL, Theodor
IPC分类号： C07D401/14 , A61K31/404 , A61K31/44 , A61K31/506 , C07D403/14 , C07D409/14 , A61P25/00 , A61P25/18
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公开(公告)号：EP3371170A1
公开(公告)日：2018-09-12
申请号：EP16791377.1
申请日：2016-11-03
发明人： GAUFRETEAU, Delphine , HILPERT, Hans , HUMM, Roland , KOLCZEWSKI, Sabine , MUSER, Thorsten , PLANCHER, Jean-Marc , STOLL, Theodor
IPC分类号： C07D401/14 , A61K31/404 , A61K31/44 , A61K31/506 , C07D403/14 , C07D409/14 , A61P25/00 , A61P25/18
CPC分类号： C07D409/14 , A61K9/0019 , A61K9/2018 , A61K9/4858 , A61K31/444 , A61K31/506 , A61K45/06 , A61K47/10 , A61K2300/00 , A61P25/08 , A61P25/16 , A61P25/18 , A61P25/22 , A61P25/24 , A61P25/28 , A61P25/32 , A61P25/36 , C07D401/14 , C07D403/04 , C07D403/14
摘要： The compounds may be used in the treatment of CNS diseases related to positive (psychosis) and negative symptoms of schizophrenia, substance abuse, alcohol and drug addiction, obsessive-compulsive disorders, cognitive impairment, bipolar disorders, mood disorders, major depression, treatment resistant depression, anxiety disorders, Alzheimer's disease, autism, Parkinson's disease, chronic pain, borderline personality disorder, neurodegenerative disease, sleep disturbances, chronic fatigue syndrome, stiffness, inflammatory disease, asthma, Huntington's disease, ADHD, amyotrophic lateral sclerosis, effects in arthritis, autoimmune disease, viral and fungal infections, cardiovascular diseases, ophthalmology and inflammatory retinal diseases and balance problems, epilepsy and neurodevelopmental disorders with co-morbid epilepsy.
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公开(公告)号：EP3371169A1
公开(公告)日：2018-09-12
申请号：EP16790362.4
申请日：2016-11-03
发明人： GAUFRETEAU, Delphine , HILPERT, Hans , HUMM, Roland , KOLCZEWSKI, Sabine , MUSER, Thorsten , PLANCHER, Jean-Marc , STOLL, Theodor
IPC分类号： C07D401/14 , C07D403/10 , C07D403/14 , C07D498/04 , A61K31/506 , A61K31/513 , A61K31/5383 , A61P9/00 , A61P25/00 , A61P27/00 , A61P31/04 , A61P31/12
CPC分类号： C07D403/14 , A61K31/506 , A61K45/06 , A61K2300/00 , A61P25/08 , A61P25/16 , A61P25/18 , A61P25/22 , A61P25/24 , A61P25/28 , A61P25/32 , A61P25/36 , C07D401/14 , C07D403/04 , C07D403/10 , C07D405/14 , C07D413/14 , C07D498/04
摘要： The compounds may be used in the treatment of CNS diseases related to positive (psychosis) and negative symptoms of schizophrenia, substance abuse, alcohol and drug addiction, obsessive-compulsive disorders, cognitive impairment, bipolar disorders, mood disorders, major depression, treatment resistant depression, anxiety disorders, Alzheimer's disease, autism, Parkinson's disease, chronic pain, borderline personality disorder, neurodegenerative disease, sleep disturbances, chronic fatigue syndrome, stiffness, inflammatory disease, asthma, Huntington's disease, ADHD, amyotrophic lateral sclerosis, effects in arthritis, autoimmune disease, viral and fungal infections, cardiovascular diseases, ophthalmology and inflammatory retinal diseases and balance problems, epilepsy and neurodevelopmental disorders with co morbid epilepsy.
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公开(公告)号：EP3160957B1
公开(公告)日：2018-06-06
申请号：EP15730199.5
申请日：2015-06-23
发明人： HILPERT, Hans , KOLCZEWSKI, Sabine , HUMM, Roland , STOLL, Theodor , MUSER, Thorsten , PLANCHER, Jean-Marc , GAUFRETEAU, Delphine
IPC分类号： C07D401/14 , C07D413/14 , C07D403/14 , C07D409/14 , C07D417/14 , C07D471/04 , A61K31/404 , A61K31/42 , A61K31/4245 , A61K31/415 , A61K31/4164 , A61K31/44 , A61K31/505 , A61P25/00
CPC分类号： C07D471/04 , A61K31/4439 , A61K31/506 , A61K45/06 , C07D401/14 , C07D403/04 , C07D403/14 , C07D409/14 , C07D413/14 , C07D417/14
摘要： The compounds may be used in the treatment of CNS diseases related to positive (psychosis) and negative symptoms of schizophrenia, substance abuse, alcohol and drug addiction, obsessive-compulsive disorders, cognitive impairment, bipolar disorders, mood disorders, major depression, treatment resistant depression, anxiety disorders, Alzheimer's disease, autism, Parkinson's disease, chronic pain, borderline personality disorder, neurodegenerative disease, sleep disturbances, chronic fatigue syndrome, stiffness, inflammatory disease, asthma, Huntington's disease, ADHD, amyotrophic lateral sclerosis, epilepsy, effects in arthritis, autoimmune disease, viral and fungal infections, cardiovascular diseases, ophthalmology and inflammatory retinal diseases and balance problems.
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公开(公告)号：EP3160957A1
公开(公告)日：2017-05-03
申请号：EP15730199.5
申请日：2015-06-23
发明人： HILPERT, Hans , KOLCZEWSKI, Sabine , HUMM, Roland , STOLL, Theodor , MUSER, Thorsten , PLANCHER, Jean-Marc , GAUFRETEAU, Delphine
IPC分类号： C07D401/14 , C07D413/14 , C07D403/14 , C07D409/14 , C07D417/14 , C07D471/04 , A61K31/404 , A61K31/42 , A61K31/4245 , A61K31/415 , A61K31/4164 , A61K31/44 , A61K31/505 , A61P25/00
CPC分类号： C07D471/04 , A61K31/4439 , A61K31/506 , A61K45/06 , C07D401/14 , C07D403/04 , C07D403/14 , C07D409/14 , C07D413/14 , C07D417/14
摘要： The compounds may be used in the treatment of CNS diseases related to positive (psychosis) and negative symptoms of schizophrenia, substance abuse, alcohol and drug addiction, obsessive-compulsive disorders, cognitive impairment, bipolar disorders, mood disorders, major depression, treatment resistant depression, anxiety disorders, Alzheimer's disease, autism, Parkinson's disease, chronic pain, borderline personality disorder, neurodegenerative disease, sleep disturbances, chronic fatigue syndrome, stiffness, inflammatory disease, asthma, Huntington's disease, ADHD, amyotrophic lateral sclerosis, epilepsy, effects in arthritis, autoimmune disease, viral and fungal infections, cardiovascular diseases, ophthalmology and inflammatory retinal diseases and balance problems.
摘要翻译： 该化合物可用于治疗与精神病（精神病）和精神分裂症，药物滥用，酒精和药物成瘾，强迫症，认知障碍，双相情感障碍，情绪障碍，重症抑郁症，耐药性治疗有关的CNS疾病 抑郁症，焦虑症，阿尔茨海默病，孤独症，帕金森病，慢性疼痛，边缘人格障碍，神经变性疾病，睡眠障碍，慢性疲劳综合征，僵硬，炎性疾病，哮喘，亨廷顿病，ADHD，肌萎缩性侧索硬化，癫痫， 关节炎，自身免疫疾病，病毒和真菌感染，心血管疾病，眼科和炎性视网膜疾病以及平衡问题。
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