公开(公告)号：EP2303889A1

公开(公告)日：2011-04-06

申请号：EP09765777.9

申请日：2009-06-10

申请人： F. Hoffmann-La Roche AG

发明人： CAI, Jianping ,  CHEN, Shaoqing ,  CHU, Xin-Jie ,  LUK, Kin-Chun Thomas ,  MISCHKE, Steven Gregory ,  SUN, Hongmao ,  WOVKULICH, Peter Michael

IPC分类号： C07D487/04 ,  A61K31/5513 ,  A61K35/00

CPC分类号： C07D487/04

摘要： The present invention provides PLK1 inhibitor compounds of formula (I): useful in the treatment or control of cell proliferative disorders, particularly oncological disorders. These compounds and formulations containing such compounds may be useful in the treatment or control of solid tumors, such as, for example, breast, colon, lung and prostate tumors and other oncological diseases such as non-Hodgkin's lymphomas. Also provided are intermediate compounds useful in the synthesis of compounds of formula (I).