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公开(公告)号：EP2872490B1
公开(公告)日：2018-02-07
申请号：EP13736570.6
申请日：2013-07-11
发明人： HAN, Xiaochun , LOU, Yan , MICHOUD, Christophe , MISCHKE, Steven Gregory , REMISZEWSKI, Stacy , RUPERT, Kenneth Carey
IPC分类号： C07D223/16 , C07D401/06 , C07D403/06 , C07D403/10 , C07D403/12 , C07D405/10 , C07D405/12 , C07D409/06 , C07D413/06 , C07D413/10 , C07D417/06 , C07D417/10 , C07D471/04 , A61K31/55 , A61P35/00
CPC分类号： C07D223/16 , C07D401/06 , C07D403/06 , C07D403/10 , C07D403/12 , C07D405/10 , C07D405/12 , C07D409/06 , C07D413/06 , C07D413/10 , C07D417/06 , C07D417/10 , C07D471/04
摘要： Disclosed are compounds of Formula (I) or pharmaceutically acceptable salts thereof, wherein W, X, Y, Z, R1, R2, R3 and R4 are described in this application, and methods of using said compounds in the treatment of cancer.
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2.发明授权4-ALKENYL (AND ALKYNYL) OXINDOLES AS INHIBITORS OF CYCLIN-DEPENDENT KINASES, IN PARTICULAR CDK2 有权4 - 烯基（和炔基）氧代吲哚作为抑制剂细胞周期蛋白依赖性激酶，特别是CDK2
公开(公告)号：EP1157019B1
公开(公告)日：2003-03-19
申请号：EP99963422.3
申请日：1999-12-08
发明人： CHEN, Yi , CORBETT, Wendy, Lea , DERMATAKIS, Apostolos , LIU, Jin-Jun , LUK, Kin-Chun , MAHANEY, Paige E. , MISCHKE, Steven Gregory
IPC分类号： C07D403/06 , A61K31/40 , C07D405/14 , C07D409/14 , C07D401/14 , C07D403/14
CPC分类号： C07D401/14 , C07D403/06 , C07D403/14 , C07D405/14 , C07D409/14
摘要： Novel 4-alkenyl- and 4-alkynyl oxindoles having formulas (I) and (II) and the pharmaceutically acceptable salts thereof, wherein R?1, R2, R3¿, a, b, and X are as defined herein inhibit cyclin-dependent kinases (CDKs), in particular CDK2 and are useful as anti-proliferative agents in the treatment or control of cell proliferative disorders, in particular breast and colon tumors.
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3.发明公开4-ALKENYL (AND ALKYNYL) OXINDOLES AS INHIBITORS OF CYCLIN-DEPENDENT KINASES, IN PARTICULAR CDK2 有权4 - 烯基（和炔基）的羟吲哚作为抑制剂细胞周期蛋白依赖性激酶，特别是CDK2
公开(公告)号：EP1157019A1
公开(公告)日：2001-11-28
申请号：EP99963422.3
申请日：1999-12-08
发明人： CHEN, Yi , CORBETT, Wendy, Lea , DERMATAKIS, Apostolos , LIU, Jin-Jun , LUK, Kin-Chun , MAHANEY, Paige E. , MISCHKE, Steven Gregory
IPC分类号： C07D403/06 , A61K31/40 , C07D405/14 , C07D409/14 , C07D401/14 , C07D403/14
CPC分类号： C07D401/14 , C07D403/06 , C07D403/14 , C07D405/14 , C07D409/14
摘要： Novel 4-alkenyl- and 4-alkynyl oxindoles having formulas (I) and (II) and the pharmaceutically acceptable salts thereof, wherein R?1, R2, R3¿, a, b, and X are as defined herein inhibit cyclin-dependent kinases (CDKs), in particular CDK2 and are useful as anti-proliferative agents in the treatment or control of cell proliferative disorders, in particular breast and colon tumors.
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4.发明公开4- AND 5-ALKYNYLOXINDOLES AND 4- AND 5-ALKENYLOXINDOLES 有权图4和5 ALKYNYLOXINDOLE和4以及5 ALKENYLOXINDOLE
公开(公告)号：EP1149092A2
公开(公告)日：2001-10-31
申请号：EP99957341.3
申请日：1999-12-07
IPC分类号： C07D403/00
CPC分类号： C07D401/14 , C07D403/06 , C07D403/14 , C07D405/14 , C07D409/14
摘要： 4- and 5-alkynyloxindoles as well as 4- and 5-alkenyloxindoles having formula (I) and (II), wherein R?1, R2, R3, R11, R12¿, X and z have the meaning indicated in the specification, inhibit or modulate protein kinases, in particular JNK protein kinases and are useful as anti-inflammatory agents, particularly in the treatment of rheumatoid arthritis.
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公开(公告)号：EP1149092B1
公开(公告)日：2003-10-29
申请号：EP99957341.3
申请日：1999-12-07
IPC分类号： C07D403/00
CPC分类号： C07D401/14 , C07D403/06 , C07D403/14 , C07D405/14 , C07D409/14
摘要： 4- and 5-alkynyloxindoles as well as 4- and 5-alkenyloxindoles having formula (I) and (II), wherein R?1, R2, R3, R11, R12¿, X and z have the meaning indicated in the specification, inhibit or modulate protein kinases, in particular JNK protein kinases and are useful as anti-inflammatory agents, particularly in the treatment of rheumatoid arthritis.
摘要翻译： 4-和5-炔基羟吲哚以及具有式（I）和（II）的4-和5-烯基羟吲哚，其中R 1，R 2，R 3，R 11，R 12，X和z具有说明书中所述的含义， 抑制或调节蛋白激酶，尤其是JNK蛋白激酶，并且可用作抗炎剂，特别是用于治疗类风湿性关节炎。
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公开(公告)号：EP1149106A2
公开(公告)日：2001-10-31
申请号：EP99964543.5
申请日：1999-12-10
IPC分类号： C07D487/04 , A61K31/4188 , A61K31/424 , A61K31/425
CPC分类号： C07D403/06 , C07D487/04 , C07D513/04 , C09B23/04
摘要： Novel 4,5-azolo-oxindoles having formula (I), wherein R1, R2, Y, Z and a have the meaning indicated in the specification, inhibit cyclin-dependent kinases (CDKs), in particular CDK2 and are useful in the treatment or control of cell proliferative disorders, in particular cancer.
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公开(公告)号：EP2931719B1
公开(公告)日：2017-01-25
申请号：EP13802359.3
申请日：2013-12-09
IPC分类号： C07D403/12 , C07D401/14 , C07D403/14 , C07D243/12 , A61K31/551 , A61P35/00
CPC分类号： C07D403/14 , C07D243/00 , C07D243/12 , C07D401/14 , C07D403/12
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8.发明公开
公开(公告)号：EP2303889A1
公开(公告)日：2011-04-06
申请号：EP09765777.9
申请日：2009-06-10
发明人： CAI, Jianping , CHEN, Shaoqing , CHU, Xin-Jie , LUK, Kin-Chun Thomas , MISCHKE, Steven Gregory , SUN, Hongmao , WOVKULICH, Peter Michael
IPC分类号： C07D487/04 , A61K31/5513 , A61K35/00
CPC分类号： C07D487/04
摘要： The present invention provides PLK1 inhibitor compounds of formula (I): useful in the treatment or control of cell proliferative disorders, particularly oncological disorders. These compounds and formulations containing such compounds may be useful in the treatment or control of solid tumors, such as, for example, breast, colon, lung and prostate tumors and other oncological diseases such as non-Hodgkin's lymphomas. Also provided are intermediate compounds useful in the synthesis of compounds of formula (I).
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公开(公告)号：EP1149106B1
公开(公告)日：2003-03-19
申请号：EP99964543.5
申请日：1999-12-10
IPC分类号： C07D487/04 , A61K31/4188 , A61K31/424 , A61K31/425
CPC分类号： C07D403/06 , C07D487/04 , C07D513/04 , C09B23/04
摘要： Novel 4,5-azolo-oxindoles having formula (I), wherein R1, R2, Y, Z and a have the meaning indicated in the specification, inhibit cyclin-dependent kinases (CDKs), in particular CDK2 and are useful in the treatment or control of cell proliferative disorders, in particular cancer.
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