公开(公告)号：EP2142520A1

公开(公告)日：2010-01-13

申请号：EP08717940.4

申请日：2008-03-18

申请人： F. Hoffmann-La Roche AG

发明人： SWEENEY, Zachary Kevin ,  WELCH, Michael

IPC分类号： C07D249/12 ,  A61K31/4196 ,  A61P31/18

CPC分类号： C07D249/12

摘要： Compounds of formula (I), wherein R1, R2, R3, R4, R5, X, Y, and Ar are as defined herein or pharmaceutically acceptable salts thereof, inhibit HIV-1 reverse transcriptase and afford a method for prevention and treatment of HIV-1 infections and the treatment of AIDS and/or ARC. The present invention also relates to compositions containing compounds of formula I useful for the prevention and treatment of HIV-1 infections and the treatment of AIDS and/or ARC.