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1.发明公开
公开(公告)号：EP3124483A1
公开(公告)日：2017-02-01
申请号：EP16180927.2
申请日：2011-11-09
发明人： BAKER-GLENN, Charles , BURDICK, Daniel Jon , CHAMBERS, Mark , CHEN, Huifen , ESTRADA, Anthony , SWEENEY, Zachary Kevin , CHAN, Bryan K.
IPC分类号： C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D413/14 , A61K31/506 , A61P25/16
CPC分类号： C07D403/14 , C07D401/14 , C07D403/12 , C07D405/14 , C07D413/14
摘要： Compounds of the formula I:
or pharmaceutically acceptable salts thereof,
wherein X, R 1 , R 2 , R 3 , R 4 and R 5 are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of diseases associated with LRRK2 receptor, such as Parkinson's disease.摘要翻译： 式I化合物或其药学上可接受的盐，其中X，R 1，R 2，R 3，R 4和R 5如本文所定义。 还公开了制备化合物和使用该化合物治疗与LRRK2受体相关的疾病如帕金森病的方法。
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公开(公告)号：EP2300459B1
公开(公告)日：2013-05-29
申请号：EP09772333.2
申请日：2009-06-22
IPC分类号： C07D403/10 , C07D403/14 , A61K31/4725 , A61P37/00 , C07D401/14 , C07D413/14 , C07D417/14
CPC分类号： C07D403/10 , C07D401/14 , C07D403/14 , C07D413/14 , C07D417/14
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公开(公告)号：EP2155692B1
公开(公告)日：2015-06-17
申请号：EP08759780.3
申请日：2008-05-20
IPC分类号： C07D233/72 , C07D233/78 , C07D239/22 , C07D239/54 , C07D239/553 , C07D239/545 , A61K31/4174 , A61K31/513 , A61P31/18
CPC分类号： C07D239/22 , C07D233/72 , C07D233/78 , C07D239/54 , C07D239/545 , C07D239/553
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公开(公告)号：EP2300459A1
公开(公告)日：2011-03-30
申请号：EP09772333.2
申请日：2009-06-22
IPC分类号： C07D403/10 , C07D403/14 , A61K31/4725 , A61P37/00 , C07D401/14 , C07D413/14 , C07D417/14
CPC分类号： C07D403/10 , C07D401/14 , C07D403/14 , C07D413/14 , C07D417/14
摘要： The present invention provides 5 -phenyl- 1H-pyrazin-2 -one derivatives according to generic Formulae I-V: wherein, variables Q, R, Y
1 , Y
2 , Y
2' , Y
3 , Y
4 , n and m are defined as described herein, which inhibit Btk. The compounds disclosed herein are useful to modulate the activity of Btk and treat diseases associated with excessive Btk activity. The compounds are further useful to treat inflammatory and auto immune diseases associated with aberrant B-cell proliferation such as rheumatoid arthritis. Also disclosed are compositions comprising compounds of Formulae I-V and at least one carrier, diluent or excipient.-
公开(公告)号：EP2155692A1
公开(公告)日：2010-02-24
申请号：EP08759780.3
申请日：2008-05-20
IPC分类号： C07D233/72 , C07D233/78 , C07D239/22 , C07D239/54 , C07D239/553 , C07D239/545 , A61K31/4174 , A61K31/513 , A61P31/18
CPC分类号： C07D239/22 , C07D233/72 , C07D233/78 , C07D239/54 , C07D239/545 , C07D239/553
摘要： Compounds of formula (I), wherein R1, X1, X2 and A, are as defined herein or pharmaceutically acceptable salts thereof, inhibit HIV-1 reverse transcriptase and afford a method for prevention and treatment of HIV-1 infections and the treatment of AIDS and/or ARC. The present invention also relates to compositions containing compounds of formula (I) useful for the prevention and treatment of HIV-1 infections and the treatment of AIDS and/or ARC.
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公开(公告)号：EP2057125A1
公开(公告)日：2009-05-13
申请号：EP07802503.8
申请日：2007-08-06
IPC分类号： C07D231/12 , C07D231/56 , C07D471/04 , C07D487/04 , A61K31/415 , A61K31/4162 , A61P31/18
CPC分类号： C07D471/04 , C07D231/12 , C07D231/56 , C07D487/04
摘要： The present invention provides for compounds useful for treating an HIV infection, or preventing an HIV infection, or treating AIDS or ARC. The compounds of the invention are of formula I wherein A is A1, A2, A3 or A4 and R1, R2, R3, R4a, R4b, R5, R6, Ar, X1, X2, X3, X4 and X5 are as herein defined. Also disclosed in the present invention are methods of treating an HIV infection with compounds defined herein and pharmaceutical compositions containing said compounds.
摘要翻译： 本发明提供可用于治疗HIV感染，或预防HIV感染，或治疗AIDS或ARC的化合物。 本发明的化合物是其中A是A1，A2，A3或A4并且R1，R2，R3，R4a，R4b，R5，R6，Ar，X1，X2，X3，X4和X5如本文所定义的式I的化合物。 本发明还公开了用本文定义的化合物治疗HIV感染的方法和含有所述化合物的药物组合物。
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公开(公告)号：EP3075730A1
公开(公告)日：2016-10-05
申请号：EP16155153.6
申请日：2011-06-01
发明人： BAKER-GLENN, Charles , BURDICK, Daniel Jon , CHAMBERS, Mark , CHAN, Bryan K. , CHEN, Huifen , ESTRADA, Anthony , GUNZNER, Janet L. , SHORE, Daniel , SWEENEY, Zachary Kevin , WANG, Shumei , ZHAO, Guiling
IPC分类号： C07D403/14 , C07D473/16 , A61K31/52
CPC分类号： C07D413/14 , C07D403/14 , C07D413/12 , C07D473/16 , C07D498/06 , C07D498/08
摘要： Compounds of the formula I or pharmaceutically acceptable salts thereof, wherein m, n. X, R 1 , R 2 , R 3 , R 5 , R 6 and R 7 are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of diseases associated with LRRK2 receptor, such as Parkinson's disease.
摘要翻译： 式I化合物或其药学上可接受的盐，其中m，n。 X，R 1，R 2，R 3，R 5，R 6和R 7如本文所定义。 还公开了制备化合物和使用该化合物治疗与LRRK2受体相关的疾病如帕金森病的方法。
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公开(公告)号：EP2225239B1
公开(公告)日：2014-10-22
申请号：EP08865894.3
申请日：2008-12-11
IPC分类号： C07D471/04 , C07D487/04 , A61K31/5025 , A61K31/437 , A61P31/12 , A61P31/18
CPC分类号： C07D471/04 , C07D487/04
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公开(公告)号：EP2142520A1
公开(公告)日：2010-01-13
申请号：EP08717940.4
申请日：2008-03-18
IPC分类号： C07D249/12 , A61K31/4196 , A61P31/18
CPC分类号： C07D249/12
摘要： Compounds of formula (I), wherein R1, R2, R3, R4, R5, X, Y, and Ar are as defined herein or pharmaceutically acceptable salts thereof, inhibit HIV-1 reverse transcriptase and afford a method for prevention and treatment of HIV-1 infections and the treatment of AIDS and/or ARC. The present invention also relates to compositions containing compounds of formula I useful for the prevention and treatment of HIV-1 infections and the treatment of AIDS and/or ARC.
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公开(公告)号：EP2134711A2
公开(公告)日：2009-12-23
申请号：EP08735604.4
申请日：2008-03-31
IPC分类号： C07D471/04 , C07D487/04 , A61K31/4353 , A61K31/4162 , A61P31/18
CPC分类号： C07D487/04 , C07D471/04
摘要： Compounds of formula (I), wherein R1, R2, R3, R4, Ra, X, X1, and Y are as defined herein or pharmaceutically acceptable salts thereof, inhibit HIV-1 reverse transcriptase and afford a method for prevention and treatment of HIV-1 infections and the treatment of AIDS and/or ARC. The present invention also relates to compositions containing compounds of formula (I) useful for the prevention and treatment of HIV-1 infections and the treatment of AIDS and/or ARC.
摘要翻译： 其中R 1，R 2，R 3，R 4，R a，X，X 1和Y如本文所定义的式（I）化合物或其药学上可接受的盐抑制HIV-1逆转录酶并提供预防和治疗HIV的方法 -1感染和艾滋病和/或ARC的治疗。 本发明还涉及含有用于预防和治疗HIV-1感染和治疗AIDS和/或ARC的式（I）化合物的组合物。
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