-
公开(公告)号：EP2297581B1
公开(公告)日：2013-04-03
申请号：EP09772167.4
申请日：2009-07-01
IPC分类号： G01N33/574
CPC分类号： G01N33/57423 , G01N2333/4742
-
公开(公告)号：EP2223116A2
公开(公告)日：2010-09-01
申请号：EP08860118.2
申请日：2008-12-08
IPC分类号： G01N33/574
CPC分类号： G01N33/57419
摘要： The present invention relates to a method for assessing colorectal cancer (CRC) in vitro comprising measuring in a sample the concentration and/or activity of a seprase polypeptide and/or fragments thereof and of either anti-p53 and/or osteopontin and/or Ferritin, of optionally one or more other marker of CRC, and using the combined measurement result in the assessment of CRC. Furthermore, it especially relates to a method for assessing CRC from a liquid sample, derived from an individual by measuring seprase and at least anti-p53, Ferritin and/or osteopontin in said sample. The method according to the present invention can, e.g., be used in the early detection of cancer by screening of asymptomatic individuals or in the surveillance of patients who undergo surgery.
-
公开(公告)号：EP1676136A1
公开(公告)日：2006-07-05
申请号：EP04790499.0
申请日：2004-10-15
发明人： PESTLIN, Gabriele , ANDRES, Herbert , BERNDT, Peter , HAGMANN, Marie-Luise , KARL, Johann , LANGEN, Hanno , ZOLG, Werner
IPC分类号： G01N33/574
CPC分类号： G01N33/57415
摘要： The present invention relates to the diagnosis of breast cancer. It discloses the use of ubiquitin-conjugating enzyme E2N (UBC13) in the diagnosis of breast cancer. It relates to a method for diagnosis of breast cancer from a liquid sample, derived from an individual by measuring UBC13 in said sample. Measurement of UBC13 can, e.g., be used in the early detection or diagnosis of breast cancer.
-
4.发明公开
公开(公告)号：EP1402015A2
公开(公告)日：2004-03-31
申请号：EP02758265.9
申请日：2002-06-24
IPC分类号： C12N9/90
CPC分类号： G01N33/56988 , A61K39/00 , A61K47/64 , C07K14/005 , C07K2319/00 , C12N9/90 , C12N2740/16122 , G01N33/54306 , G01N33/56911 , G01N33/56983 , G01N2333/005 , G01N2333/16 , G01N2333/195 , G01N2469/20
摘要： The present invention relates to the diagnosis of HIV infections. It especially teaches the production of a soluble retroviral surface glycoprotein- (or transmembrane glycoprotein)- chaperone complex and the advantageous use of a chaperone-antigen complex especially in the detection of antibodies to HIV in immunoassays, preferably according to the double antigen bridge concept, or as an immunogen. The invention also discloses soluble complexes comprising a variant of HIV-1 gp41 or a variant of HIV-2 gp36, respectively, and a chaperone selected from the peptidyl-prolyl-isomerase class of chaperones. Variants comprising specific amino-acid substitutions in the N-helical domain of HIV-1 gp41 or of HIV-2 gp36, respectively are also described.
-
5.发明授权
公开(公告)号：EP3472622B1
公开(公告)日：2020-08-05
申请号：EP17733406.7
申请日：2017-06-19
发明人： ANDRES, Herbert , BLOCK, Dirk , KARL, Johann , KASTNER, Peter , WIENHUES-THELEN, Ursula-Henrike , LATINI, Roberto , MASSON, Serge , ZIEGLER, André , KAISER, Edelgard , PALME, Stefan , THOMAS, Markus , BARLERA, Simona
IPC分类号： G01N33/68
-
6.发明公开
公开(公告)号：EP2684051A1
公开(公告)日：2014-01-15
申请号：EP12707316.1
申请日：2012-03-07
发明人： ANDRES, Herbert , KARL, Johann , RIEDLINGER, Julia
IPC分类号： G01N33/68
CPC分类号： G01N33/6893 , G01N33/6884 , G01N2333/4703 , G01N2800/122
摘要： The present invention relates to an in vitro method aiding in the assessment of chronic obstructive pulmonary disease (=COPD). It discloses the use of the protein ASC as a marker of COPD. Furthermore, it especially relates to a method for assessing COPD from a sample, derived from an individual by measuring the protein ASC in said sample in vitro.
-
公开(公告)号：EP2297581A1
公开(公告)日：2011-03-23
申请号：EP09772167.4
申请日：2009-07-01
IPC分类号： G01N33/574
CPC分类号： G01N33/57423 , G01N2333/4742
摘要： The present invention relates to the assessment of lung cancer. It discloses the use of protein ASC in the assessment of lung cancer. It also relates to a method for assessing lung cancer in vitro using a liquid sample, derived from an individual by measuring ASC in said sample. Measurement of ASC can, e.g., be used in the early detection or in the follow-up of patients with lung cancer.
摘要翻译： 本发明涉及肺癌的评估。 它公开了蛋白质ASC在评估肺癌中的用途。 本发明还涉及使用液体样品体外评估肺癌的方法，所述液体样品通过测量所述样品中的ASC从个体获得。 ASC的测量可以例如用于肺癌患者的早期检测或随访中。
-
8.发明公开USE OF PROTEIN CELLULAR RETINOIC ACID-BINDING PROTEIN II (CRABP II) AS MARKER FOR BREAST CANCER 有权中蛋白质CRABP II（CELLULAR视黄酸结合蛋白II）作为标志物用于乳腺癌USE
公开(公告)号：EP1636584A1
公开(公告)日：2006-03-22
申请号：EP04739585.0
申请日：2004-06-04
发明人： PESTLIN, Gabriele , ANDRES, Herbert , BERNDT, Peter , HAGMANN, Marie-Luise , KARL, Johann , LANGEN, Hanno , ZOLG, Werner
IPC分类号： G01N33/574
CPC分类号： G01N33/57415 , G01N33/57473 , G01N2333/70567
摘要： The present invention relates to the diagnosis of breast cancer. It discloses the use of protein cellular retinoic acid-binding protein II in the diagnosis of breast cancer. It relates to a method for diagnosis of breast cancer from a liquid sample, derived from an individual by measuring cellular retinoic acid-binding protein II in said sample. Measurement of cellular retinoic acid-binding protein II can, e.g., be used in the early detection or diagnosis of breast cancer.
-
公开(公告)号：EP1364208B1
公开(公告)日：2005-12-21
申请号：EP01969773.9
申请日：2001-09-26
发明人： HOESS, Eva , ANDRES, Herbert , DONIE, Frederic , VOGEL, Rudolf , JOSEL, Hans-Peter , HERRMANN, Rupert , VON DER ELTZ, Herbert
IPC分类号： G01N33/531
CPC分类号： C07K1/1077 , A61K47/643 , A61K47/6889 , G01N33/5306 , G01N33/531 , G01N33/68 , G01N33/6845 , Y10S435/961 , Y10S435/962
-
公开(公告)号：EP1364208A2
公开(公告)日：2003-11-26
申请号：EP01969773.9
申请日：2001-09-26
发明人： HOESS, Eva , ANDRES, Herbert , DONIE, Frederic , VOGEL, Rudolf , JOSEL, Hans-Peter , HERRMANN, Rupert , VON DER ELTZ, Herbert
IPC分类号： G01N33/531
CPC分类号： C07K1/1077 , A61K47/643 , A61K47/6889 , G01N33/5306 , G01N33/531 , G01N33/68 , G01N33/6845 , Y10S435/961 , Y10S435/962
摘要： The invention relates to a process for the production of a biomolecule-linker conjugate of uniform stochiometry. It especially relates to a conjugate consisting of a biomolecule of a molecular weight between 5 kD and 500 kD and a hydrophilic linker molecule said linker having a molecular weight between 1 and 15 kD and between 4 and 60 charged residues, characterized in that said conjugate comprises at least one biomelecule-linker product of uniform stoichiometry in a pre-selected amount.
-
-
-
-
-
-
-
-
-
搜索结果
44 条记录 (耗时 0.025 秒)
