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公开(公告)号：EP2464640A1
公开(公告)日：2012-06-20
申请号：EP10739948.7
申请日：2010-08-06
IPC分类号： C07D403/04 , C07D401/14 , A61K31/506 , A61P29/00 , A61P25/00 , A61P35/00
CPC分类号： C07D403/04 , C07D401/14
摘要： The invention relates to JNK inhibitors and corresponding methods, formulations, and compositions for inhibiting JNK and treating JNK-mediated disorders. The application discloses JNK inhibitors, as described below in Formula I: wherein p, q, Y', r, R
1 , R
2 , X, X
1 , X
2 , X
3 , and X
4 are as defined herein. The compounds and compositions disclosed herein are useful to modulate the activity of JNK and treat diseases associated with JNK activity. Disclosed are methods and formulations for inhibiting JNK and treating JNK-mediated disorders, and the like, with the compounds, and processes for making said compounds, and corresponding compositions, disclosed herein.摘要翻译： 本发明涉及用于抑制JNK和治疗JNK介导的病症的JNK抑制剂和相应的方法，制剂和组合物。 该申请公开了如下式I所述的JNK抑制剂：其中p，q，Y'，r，R 1，R 2，X，X 1，X 2，X 3和X 4如本文所定义。 本文公开的化合物和组合物可用于调节JNK的活性并治疗与JNK活性相关的疾病。 公开了用于抑制JNK和治疗JNK介导的病症等的方法和制剂，以及用于制备所述化合物的化合物和方法以及本文公开的相应组合物。
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公开(公告)号：EP1756054B1
公开(公告)日：2010-03-31
申请号：EP05747507.1
申请日：2005-05-27
发明人： GREENHOUSE, Robert , JAIME-FIGUEROA, Saul , RAPTOVA, Lubica , REUTER, Deborah, Carol , STEIN, Karin, Ann , WEIKERT, Robert, James
IPC分类号： C07D209/04 , A61K31/4045
CPC分类号： C07D401/06 , C07D209/08 , C07D209/14 , C07D231/56 , C07D307/14
摘要： Compounds of formula I: or pharmaceutically acceptable salts thereof, wherein p, Ar, R1, R2, R3, Ra, Rb, Rc, Rd and Re are defined herein, pharmaceutical compositions containing them and methods of using them for the preparation of medicaments for treating depression or anxiety.
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公开(公告)号：EP1957488A1
公开(公告)日：2008-08-20
申请号：EP06819602.1
申请日：2006-11-20
发明人： GREENHOUSE, Robert , JAIME-FIGUEROA, Saul , LYNCH, Stephen M. , RAPTOVA, Lubica , STEIN, Karin Ann , WEIKERT, Robert James
IPC分类号： C07D471/04 , C07D487/04 , C07D487/14 , A61K31/395 , A61K31/437 , A61P25/22 , A61P25/24
CPC分类号： C07D471/04 , C07D487/04 , C07D487/14
摘要： The present invention provides compounds of the formula I: or pharmaceutically acceptable salts, solvates or prodrugs thereof, wherein p, Ar, R1, R2, R3, Ra, Rb, Rc, Rd and Re are defined herein. Also provided are pharmaceutical compositions, methods of using, and methods of preparing the compounds. The compounds are useful for the treatment of diseases associated with monoamine reuptake inhibitors.
摘要翻译： 本发明提供了式I化合物或其药学上可接受的盐，溶剂合物或前药，其中p，Ar，R 1，R 2，R 3，R a，R b，R c，R d和R e如本文所定义。 还提供了药物组合物，使用方法和制备该化合物的方法。 该化合物可用于治疗与单胺再摄取抑制剂有关的疾病。
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公开(公告)号：EP1957488B1
公开(公告)日：2009-09-09
申请号：EP06819602.1
申请日：2006-11-20
发明人： GREENHOUSE, Robert , JAIME-FIGUEROA, Saul , LYNCH, Stephen M. , RAPTOVA, Lubica , STEIN, Karin Ann , WEIKERT, Robert James
IPC分类号： C07D471/04 , C07D487/04 , C07D487/14 , A61K31/395 , A61K31/437 , A61P25/22 , A61P25/24
CPC分类号： C07D471/04 , C07D487/04 , C07D487/14
摘要： The present invention provides compounds of the formula I: or pharmaceutically acceptable salts, solvates or prodrugs thereof, wherein p, Ar, R1, R2, R3, Ra, Rb, Rc, Rd and Re are defined herein. Also provided are pharmaceutical compositions, methods of using, and methods of preparing the compounds. The compounds are useful for the treatment of diseases associated with monoamine reuptake inhibitors.
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公开(公告)号：EP1756054A1
公开(公告)日：2007-02-28
申请号：EP05747507.1
申请日：2005-05-27
发明人： GREENHOUSE, Robert , JAIME-FIGUEROA, Saul , RAPTOVA, Lubica , REUTER, Deborah, Carol , STEIN, Karin, Ann , WEIKERT, Robert, James
IPC分类号： C07D209/04 , A61K31/4045
CPC分类号： C07D401/06 , C07D209/08 , C07D209/14 , C07D231/56 , C07D307/14
摘要： Compounds of formula I: or pharmaceutically acceptable salts thereof, wherein p, Ar, R1, R2, R3, Ra, Rb, Rc, Rd and Re are defined herein, pharmaceutical compositions containing them and methods of using them for the preparation of medicaments for treating depression or anxiety.
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