-
1.发明授权NOVEL 4-AMINO-3-(-AZOLYL-PHENOXYMETHYL)-THIENOÝ3,2¨PYRIDINE-7-CARBOXYLIC ACID DERIVATIVES 有权NEW 4-氨基-3 - （ - AZOLYLPHENOXYMETHYL）噻吩并[3,2-c]吡啶-7-羧酸衍生物
公开(公告)号：EP2038288B1
公开(公告)日：2010-11-24
申请号：EP07730300.6
申请日：2007-06-22
IPC分类号： C07D495/04 , A61K31/4365 , A61P35/00
CPC分类号： C07D495/04
摘要： There are provided compounds of the formula (I) wherein R1 , R2 , R3 , X, ring A and ring B are as described. The compounds exhibit anticancer properties.
-
公开(公告)号：EP2504324A1
公开(公告)日：2012-10-03
申请号：EP10782584.6
申请日：2010-11-19
发明人： ANDERSON, Kevin William , GILLESPIE, Paul , HUBY, Nicholas John Silvester , KONG, Norman , ROBERTS, John Lawson , ROSSMAN, Pamela Loreen , SO, Sung-Sau
IPC分类号： C07D275/06 , A61K31/425 , A61P35/00
CPC分类号： C07D275/06
摘要： The present invention relates to compounds according to formula (1), and pharmaceutically-acceptable salts thereof, wherein R
2 , R
3 , R
4 , R
5 , and R
6 are as defined herein.-
公开(公告)号：EP1926737A1
公开(公告)日：2008-06-04
申请号：EP06793204.6
申请日：2006-09-05
发明人： BARTKOVITZ, David Joseph , CHEN, Yi , CHU, Xin-Jie , LUK, Kin-Chun , ROSSMAN, Pamela Loreen , SO, Sung-Sau
IPC分类号： C07D495/04 , A61K31/435 , A61P35/00
CPC分类号： C07D495/04 , Y02P20/582
摘要： The present invention relates to compounds of the formula (I-A) medicaments containing them and the use of these compounds as pharmaceutically active agents. The compounds exhibit activity as Raf kinase inhibitors and therefore may be useful for the treatment of diseases mediated by said kinases, especially as anticancer agents.
-
公开(公告)号：EP2504324B1
公开(公告)日：2015-02-25
申请号：EP10782584.6
申请日：2010-11-19
发明人： ANDERSON, Kevin William , GILLESPIE, Paul , HUBY, Nicholas John Silvester , KONG, Norman , ROBERTS, John Lawson , ROSSMAN, Pamela Loreen , SO, Sung-Sau
IPC分类号： C07D275/06 , A61K31/425 , A61P35/00
CPC分类号： C07D275/06
-
5.发明公开NOVEL 4-AMINO-3-(-AZOLYL-PHENOXYMETHYL)-THIENOÝ3,2¨PYRIDINE-7-CARBOXYLIC ACID DERIVATIVES 有权NEUE 4-氨基-3-（ - 三唑基甲基）三苯并[3,2-C]吡啶-7-碳酸二乙酯
公开(公告)号：EP2038288A1
公开(公告)日：2009-03-25
申请号：EP07730300.6
申请日：2007-06-22
IPC分类号： C07D495/04 , A61K31/4365 , A61P35/00
CPC分类号： C07D495/04
摘要： There are provided compounds of the formula (I) wherein R1 , R2 , R3 , X, ring A and ring B are as described. The compounds exhibit anticancer properties.
-
6.发明公开
公开(公告)号：EP1917015A1
公开(公告)日：2008-05-07
申请号：EP05792209.8
申请日：2005-08-16
发明人： LUK, Kin-Chun , MCDERMOTT, Lee Apostle , ROSSMAN, Pamela Loreen , WOVKULICH, Peter Michael , ZHANG, Zhuming
IPC分类号： A61K31/4365 , A61P35/00 , C07D495/04
CPC分类号： C07D495/04
摘要： The present invention relates to novel 4-amino-thieno[3,2-c]pyridine-7-carboxylic acid amides of formula (I), and their pharmaceutically acceptable salts and esters which compounds of formula (I) are selective inhibitors of KDR and/or FGFR kinases. These compounds and their pharmaceutically acceptable salts are anti-proliferative agents useful in the treatment or control of solid tumors, in particular solid tumors of the breast, colon, lung and prostate. Also disclosed are pharmaceutical compositions or medicaments containing these compounds, processes for making them and methods of treating cancer using these compounds.
-
-
-
-
-
搜索结果
6 条记录 (耗时 0.018 秒)
