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公开(公告)号：EP1989186A1
公开(公告)日：2008-11-12
申请号：EP07726336.6
申请日：2007-02-12
发明人： CHEN, Shaoqing , HUBY, Nicholas John Silvester , KONG, Norman , MISCHKE, Steven Gregory , MOLITERNI, John Anthony , WANG, Hong , ZHANG, Zhuming
IPC分类号： C07D233/76 , C07D233/78 , A61K31/4166 , A61K31/4178
CPC分类号： C07D233/76 , C07D233/78 , C07D401/04 , C07D401/06 , C07D403/06 , C07D405/04 , C07D405/12 , C07D407/04 , C07D407/12 , C07D409/04 , C07D409/06 , C07D417/06
摘要： The present invention relates to compounds of the formula (I), pharmaceutical compositions containing said compounds, methods for the preparation thereof, and methods for their use. The compounds are useful in treating diseases characterized by the hyperactivity of MEK. Accordingly the compounds are useful in the treatment of diseases, such as cancer, cognitive and CNS disorders, and inflammatory/autoimmune diseases.
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公开(公告)号：EP2758370A1
公开(公告)日：2014-07-30
申请号：EP12753948.4
申请日：2012-08-29
IPC分类号： C07C317/44 , C07D237/18 , A61K31/495 , A61K31/167 , A61P35/00
CPC分类号： C07C317/44 , C07C2601/08 , C07C2601/14 , C07D237/18
摘要： The present application disclosed compounds of Formula I wherein variables R
1 and R
2 are defined as described herein, which are inhibitors of PARP and provides compounds and compositions containing the compounds of Formula I. The present application further provides methods of using the disclosed PARP inhibitors for the treatment of PARP-mediated diseases and disorders.摘要翻译： 本申请公开了式I的化合物，其中变量R1和R2如本文所述定义，其是PARP的抑制剂，并提供含有式I化合物的化合物和组合物。本申请还提供了使用所公开的PARP抑制剂用于 治疗PARP介导的疾病和病症。
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公开(公告)号：EP2504324A1
公开(公告)日：2012-10-03
申请号：EP10782584.6
申请日：2010-11-19
发明人： ANDERSON, Kevin William , GILLESPIE, Paul , HUBY, Nicholas John Silvester , KONG, Norman , ROBERTS, John Lawson , ROSSMAN, Pamela Loreen , SO, Sung-Sau
IPC分类号： C07D275/06 , A61K31/425 , A61P35/00
CPC分类号： C07D275/06
摘要： The present invention relates to compounds according to formula (1), and pharmaceutically-acceptable salts thereof, wherein R
2 , R
3 , R
4 , R
5 , and R
6 are as defined herein.-
公开(公告)号：EP2931721A1
公开(公告)日：2015-10-21
申请号：EP13805327.7
申请日：2013-12-09
IPC分类号： C07D417/14 , A61K31/445 , A61P37/00 , A61P29/00 , A61P19/00
CPC分类号： C07D417/14
摘要： This application discloses compounds according to generic Formula I: wherein all variables are defined as described herein, which inhibit Btk. The compounds disclosed herein are useful to modulate the activity of Btk and treat diseases associated with excessive Btk activity. The compounds are further useful to treat inflammatory and auto immune diseases associated with aberrant B-cell proliferation such as rheumatoid arthritis. Also disclosed are compositions containing compounds of Formula I and at least one carrier, diluent or excipient.
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公开(公告)号：EP2504324B1
公开(公告)日：2015-02-25
申请号：EP10782584.6
申请日：2010-11-19
发明人： ANDERSON, Kevin William , GILLESPIE, Paul , HUBY, Nicholas John Silvester , KONG, Norman , ROBERTS, John Lawson , ROSSMAN, Pamela Loreen , SO, Sung-Sau
IPC分类号： C07D275/06 , A61K31/425 , A61P35/00
CPC分类号： C07D275/06
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公开(公告)号：EP2931721B1
公开(公告)日：2016-10-26
申请号：EP13805327.7
申请日：2013-12-09
IPC分类号： C07D417/14 , A61K31/445 , A61P37/00 , A61P29/00 , A61P19/00
CPC分类号： C07D417/14
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公开(公告)号：EP1989186B1
公开(公告)日：2010-11-17
申请号：EP07726336.6
申请日：2007-02-12
发明人： CHEN, Shaoqing , HUBY, Nicholas John Silvester , KONG, Norman , MISCHKE, Steven Gregory , MOLITERNI, John Anthony , WANG, Hong , ZHANG, Zhuming
IPC分类号： C07D233/76 , C07D233/78 , A61K31/4166 , A61K31/4178
CPC分类号： C07D233/76 , C07D233/78 , C07D401/04 , C07D401/06 , C07D403/06 , C07D405/04 , C07D405/12 , C07D407/04 , C07D407/12 , C07D409/04 , C07D409/06 , C07D417/06
摘要： The present invention relates to compounds of the formula (I), pharmaceutical compositions containing said compounds, methods for the preparation thereof, and methods for their use. The compounds are useful in treating diseases characterized by the hyperactivity of MEK. Accordingly the compounds are useful in the treatment of diseases, such as cancer, cognitive and CNS disorders, and inflammatory/autoimmune diseases.
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