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公开(公告)号：EP2882725A1
公开(公告)日：2015-06-17
申请号：EP13747659.4
申请日：2013-08-06
发明人： DONNELL, Andrew F. , HAN,Xiaochun , KESTER, Robert Francis , KONG, Norman , LE, Kang , LOU, Yan , MICHOUD, Christophe , MOLITERNI, John Anthony , REMISZEWSKI, Stacy , RUPERT, Kenneth Carey , YUN, Weiya
IPC分类号： C07D267/14 , C07D498/10 , C07D281/10 , A61K31/553 , A61K31/554
CPC分类号： C07D267/14 , C07D267/12 , C07D281/10 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/06 , C07D417/12 , C07D498/10
摘要： There are provided compounds of the formula (1) wherein W, X, Y, Z, R1, R2, R3, R4, R5 and R6 are described herein. These compounds are useful for the treatment of proliferative diseases, including cancer.
摘要翻译： 提供下式化合物其中：本文描述了V，W，X，Y，Z，R 1，R 2，R 3，R 4，R 5和R 6。 该化合物可用于治疗包括癌症在内的增殖性疾病。
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公开(公告)号：EP2504324A1
公开(公告)日：2012-10-03
申请号：EP10782584.6
申请日：2010-11-19
发明人： ANDERSON, Kevin William , GILLESPIE, Paul , HUBY, Nicholas John Silvester , KONG, Norman , ROBERTS, John Lawson , ROSSMAN, Pamela Loreen , SO, Sung-Sau
IPC分类号： C07D275/06 , A61K31/425 , A61P35/00
CPC分类号： C07D275/06
摘要： The present invention relates to compounds according to formula (1), and pharmaceutically-acceptable salts thereof, wherein R
2 , R
3 , R
4 , R
5 , and R
6 are as defined herein.-
3.发明公开CIS-2,4,5- TRIPHENYL-IMIDAZOLINES AND THEIR USE IN THE TREATMENT OF TUMORS 有权CIS-2,4,5-三苯基咪唑啉它们在肿瘤的治疗
公开(公告)号：EP1458380A1
公开(公告)日：2004-09-22
申请号：EP02804883.3
申请日：2002-12-09
发明人： KONG, Norman , LIU, Emily, Aijun , VU, Binh, Thanh
IPC分类号： A61K31/4164 , C07D233/22 , C07D233/24 , C07D233/26 , C07D401/06 , C07D403/06 , C07D405/06 , C07D405/10 , C07D409/06 , C07D413/06 , C07D521/00 , A61K31/422 , A61K31/454 , A61K31/4545 , A61K31/501
CPC分类号： C07D401/06 , C07D233/22 , C07D233/24 , C07D233/26 , C07D403/06 , C07D403/12 , C07D405/04 , C07D409/06 , C07D413/06
摘要： The present invention provides compounds according to formula I and formula II and pharmaceutically acceptable salts ad esters thereof, having the designations provides herein and which inhibit the interaction of MDM2 protein with a p53-like peptide and have antiproliferative activity. Formula (I).
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公开(公告)号：EP3080098A1
公开(公告)日：2016-10-19
申请号：EP14809643.1
申请日：2014-12-10
IPC分类号： C07D401/14 , C07D403/06 , A61K31/4155 , A61K31/4439 , A61P29/00 , A61P11/06
CPC分类号： C07D403/06 , C07D401/14
摘要： This application discloses compounds according to generic Formula (I): wherein all variables are defined as described herein, which inhibit Btk. The compounds disclosed herein are useful to modulate the activity of Btk and treat diseases associated with excessive Btk activity. The compounds are useful for the treatment of oncological, auto-immune, and inflammatory diseases caused by aberrant B-cell activation. Also disclosed are compositions containing compounds of Formula I and at least one carrier, diluent or excipient.
摘要翻译： 该申请公开了根据通式（I）的化合物：其中所有变量如本文所述定义，其抑制Btk。 本文公开的化合物可用于调节Btk的活性并治疗与过度Btk活性相关的疾病。 该化合物可用于治疗由异常B细胞活化引起的肿瘤，自身免疫和炎性疾病。 还公开了含有式I化合物和至少一种载体，稀释剂或赋形剂的组合物。
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公开(公告)号：EP2504324B1
公开(公告)日：2015-02-25
申请号：EP10782584.6
申请日：2010-11-19
发明人： ANDERSON, Kevin William , GILLESPIE, Paul , HUBY, Nicholas John Silvester , KONG, Norman , ROBERTS, John Lawson , ROSSMAN, Pamela Loreen , SO, Sung-Sau
IPC分类号： C07D275/06 , A61K31/425 , A61P35/00
CPC分类号： C07D275/06
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6.发明授权CIS-2,4,5- TRIPHENYL-IMIDAZOLINES AND THEIR USE IN THE TREATMENT OF TUMORS 有权CIS-2,4,5-三苯基咪唑啉它们在肿瘤的治疗
公开(公告)号：EP1458380B1
公开(公告)日：2008-03-19
申请号：EP02804883.3
申请日：2002-12-09
发明人： KONG, Norman , LIU, Emily, Aijun , VU, Binh, Thanh
IPC分类号： A61K31/4164 , C07D233/22 , C07D233/24 , C07D233/26 , C07D401/06 , C07D403/06 , C07D405/06 , C07D405/10 , C07D409/06 , C07D413/06 , C07D521/00 , A61K31/422 , A61K31/454 , A61K31/4545 , A61K31/501
CPC分类号： C07D401/06 , C07D233/22 , C07D233/24 , C07D233/26 , C07D403/06 , C07D403/12 , C07D405/04 , C07D409/06 , C07D413/06
摘要： The present invention provides compounds according to formula I and formula II and pharmaceutically acceptable salts ad esters thereof, having the designations provides herein and which inhibit the interaction of MDM2 protein with a p53-like peptide and have antiproliferative activity. Formula (I).
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公开(公告)号：EP1989186A1
公开(公告)日：2008-11-12
申请号：EP07726336.6
申请日：2007-02-12
发明人： CHEN, Shaoqing , HUBY, Nicholas John Silvester , KONG, Norman , MISCHKE, Steven Gregory , MOLITERNI, John Anthony , WANG, Hong , ZHANG, Zhuming
IPC分类号： C07D233/76 , C07D233/78 , A61K31/4166 , A61K31/4178
CPC分类号： C07D233/76 , C07D233/78 , C07D401/04 , C07D401/06 , C07D403/06 , C07D405/04 , C07D405/12 , C07D407/04 , C07D407/12 , C07D409/04 , C07D409/06 , C07D417/06
摘要： The present invention relates to compounds of the formula (I), pharmaceutical compositions containing said compounds, methods for the preparation thereof, and methods for their use. The compounds are useful in treating diseases characterized by the hyperactivity of MEK. Accordingly the compounds are useful in the treatment of diseases, such as cancer, cognitive and CNS disorders, and inflammatory/autoimmune diseases.
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公开(公告)号：EP3080099A1
公开(公告)日：2016-10-19
申请号：EP14809645.6
申请日：2014-12-10
IPC分类号： C07D401/14 , C07D403/06 , C07D403/14 , A61K31/4155 , A61K31/4439 , A61P29/00 , A61P11/06
CPC分类号： C07D403/06 , A61K31/4155 , A61K31/4439 , C07D401/14 , C07D403/14 , C07D487/04
摘要： This application discloses compounds according to generic Formula (I) wherein all variables are defined as described herein, which inhibit Btk. The compounds disclosed herein are useful to modulate the activity of Btk and treat diseases associated with excessive Btk activity. The compounds are useful for the treatment of oncological, auto-immune, and inflammatory diseases caused by aberrant B-cell activation. Also disclosed are compositions containing compounds of Formula (I) and at least one carrier, diluent or excipient.
摘要翻译： 该申请公开了根据通式（I）的化合物，其中所有变量如本文所述定义，其抑制Btk。 本文公开的化合物可用于调节Btk的活性并治疗与过度Btk活性相关的疾病。 该化合物可用于治疗由异常B细胞活化引起的肿瘤，自身免疫和炎性疾病。 还公开了含有式（I）化合物和至少一种载体，稀释剂或赋形剂的组合物。
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公开(公告)号：EP1989186B1
公开(公告)日：2010-11-17
申请号：EP07726336.6
申请日：2007-02-12
发明人： CHEN, Shaoqing , HUBY, Nicholas John Silvester , KONG, Norman , MISCHKE, Steven Gregory , MOLITERNI, John Anthony , WANG, Hong , ZHANG, Zhuming
IPC分类号： C07D233/76 , C07D233/78 , A61K31/4166 , A61K31/4178
CPC分类号： C07D233/76 , C07D233/78 , C07D401/04 , C07D401/06 , C07D403/06 , C07D405/04 , C07D405/12 , C07D407/04 , C07D407/12 , C07D409/04 , C07D409/06 , C07D417/06
摘要： The present invention relates to compounds of the formula (I), pharmaceutical compositions containing said compounds, methods for the preparation thereof, and methods for their use. The compounds are useful in treating diseases characterized by the hyperactivity of MEK. Accordingly the compounds are useful in the treatment of diseases, such as cancer, cognitive and CNS disorders, and inflammatory/autoimmune diseases.
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