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公开(公告)号：EP2560683B1
公开(公告)日：2016-12-14
申请号：EP11718831.8
申请日：2011-04-22
CPC分类号： C07K16/468 , A61K2039/505 , C07K16/244 , C07K16/247 , C07K16/2863 , C07K16/30 , C07K2317/31 , C07K2317/526 , C07K2317/73 , C07K2317/76 , C07K2317/90 , C07K2317/92 , Y02A50/41
摘要： Described herein are methods for the efficient production of antibodies and other multimeric protein complexes (collectively referred to herein as heteromultimeric proteins) capable of specifically binding to more than one target. The targets may be, for example, different epitopes on a single molecule or located on different molecules. The methods combine efficient, high gene expression level, appropriate assembly, and ease of purification for the heteromultimeric proteins. The invention also provides methods of using these heteromultimeric proteins, and compositions, kits and articles of manufacture comprising these antibodies.
摘要翻译： 本文描述了能够有效地产生能够特异性结合多于一个靶的抗体和其它多聚体蛋白复合物（统称为异源多聚体蛋白质）的方法。 靶可以是例如在单个分子上或位于不同分子上的不同表位。 该方法结合了有效，高基因表达水平，合适的组装和异源多聚体蛋白质的纯化方便。 本发明还提供使用这些异源多聚体蛋白质的方法，以及包含这些抗体的组合物，试剂盒和制品。
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公开(公告)号：EP2560683A2
公开(公告)日：2013-02-27
申请号：EP11718831.8
申请日：2011-04-22
CPC分类号： C07K16/468 , A61K2039/505 , C07K16/244 , C07K16/247 , C07K16/2863 , C07K16/30 , C07K2317/31 , C07K2317/526 , C07K2317/73 , C07K2317/76 , C07K2317/90 , C07K2317/92 , Y02A50/41
摘要： Described herein are methods for the efficient production of antibodies and other multimeric protein complexes (collectively referred to herein as heteromultimeric proteins) capable of specifically binding to more than one target. The targets may be, for example, different epitopes on a single molecule or located on different molecules. The methods combine efficient, high gene expression level, appropriate assembly, and ease of purification for the heteromultimeric proteins. The invention also provides methods of using these heteromultimeric proteins, and compositions, kits and articles of manufacture comprising these antibodies.
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公开(公告)号：EP3086807A1
公开(公告)日：2016-11-02
申请号：EP14827379.0
申请日：2014-12-23
发明人： CHEN, Yongmei , ERNST, James , KIM, Hok Seon , SONODA, Junichiro , SPIESS, Christoph , STAWICKI, Scott , WU, Yan
IPC分类号： A61K39/395 , C07K14/71 , C07K16/18 , C07K16/28 , C07K16/46
CPC分类号： C07K16/40 , A61K2039/505 , C07K14/71 , C07K16/2863 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/33 , C07K2317/34 , C07K2317/40 , C07K2317/41 , C07K2317/51 , C07K2317/515 , C07K2317/524 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/71 , C07K2317/75 , C07K2317/92
摘要： The presently disclosed subject matter provides antibodies that bind KLB and FGFR1, and methods of using the same. In certain embodiments, an antibody of the present disclosure includes a bispecific antibody that binds to an epitope present on FGFR1 and binds to an epitope present on KLB.
摘要翻译： 目前公开的主题提供了结合KLB和FGFR1的抗体及其使用方法。 在某些实施方案中，本公开的抗体包括结合存在于FGFR1上并与KLB上存在的表位结合的双特异性抗体。
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公开(公告)号：EP2981286A2
公开(公告)日：2016-02-10
申请号：EP14779789.8
申请日：2014-04-04
发明人： YANSURA, Daniel G. , CHIANG, Nancy Y. , DENNIS, Mark S. , DILLON, Michael , FUH, Germaine G. , NAKAMURA, Gerald R. , SPIESS, Christoph , WU, Lawren C. , ZHANG, Yin
IPC分类号： A61K39/00 , A61K39/395 , C07K16/00
CPC分类号： C07K16/247 , A61K39/3955 , A61K45/06 , A61K2039/505 , A61K2039/54 , A61K2039/545 , C07K16/244 , C07K2317/14 , C07K2317/24 , C07K2317/31 , C07K2317/51 , C07K2317/56 , C07K2317/76 , C07K2317/92
摘要： The invention provides anti-IL-4 antibodies and bispecific antibodies and methods of using the same.
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