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公开(公告)号：EP2882776A1
公开(公告)日：2015-06-17
申请号：EP13751040.0
申请日：2013-08-13
发明人： SIEBEL, Christian W. , WU, Yan
IPC分类号： C07K16/28 , C07K16/30 , A61K39/395 , A61P35/00
CPC分类号： C07K16/28 , A61K2039/505 , C07K16/30 , C07K2317/21 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： The disclosure provides anti-Jagged antibodies and methods of using the same.
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公开(公告)号：EP2710035A1
公开(公告)日：2014-03-26
申请号：EP12722058.0
申请日：2012-05-15
发明人： SONODA, Junichiro , WU, Yan
IPC分类号： C07K16/28 , A61P3/10 , A61K39/395
CPC分类号： C07K16/2863 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K16/28 , C07K16/40 , C07K2317/31 , C07K2317/34 , C07K2317/35 , C07K2317/56 , C07K2317/75 , C07K2317/92
摘要： The disclosure provides FGFR1 agonists, including agonistic anti-FGFRl antibodies, and methods of using the same.
摘要翻译： 本发明提供FGFR1激动剂，包括激动性抗FGFR1抗体及其使用方法。
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公开(公告)号：EP2550295A1
公开(公告)日：2013-01-30
申请号：EP11711425.6
申请日：2011-03-23
发明人： BOURHIS, Eric , CARANO, Rick , COCHRAN, Andrea , COSTA, Mike , DE ALMEIDA, Venita , ERNST, James , GONG, Yan , HANNOUSH, Rami , POLAKIS, Paul , RUBINFELD, Bonnee , SOLLOWAY, Mark , WU, Yan , CAO, Tim Christopher
IPC分类号： C07K16/28 , A61K39/395 , A61P35/00
CPC分类号： C07K16/28 , A61K39/3955 , A61K2039/505 , A61K2039/507 , C07K16/2863 , C07K2317/21 , C07K2317/31 , C07K2317/34 , C07K2317/526 , C07K2317/55 , C07K2317/75 , C07K2317/76 , C07K2317/92 , C07K2319/00
摘要： The invention provides anti-LRP6 antibodies and methods of using the same. A particular aspect of the invention provides for bispecific anti-LRP6 antibodies that inhibit signaling by multiple Wnt isoforms.
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公开(公告)号：EP2414395A1
公开(公告)日：2012-02-08
申请号：EP10711526.3
申请日：2010-03-31
发明人： ELKINS, Kristi , POLSON, Andrew , EBENS, Allen , ADAMS, Camelia , ZHENG, Bing , JUNUTULA, Jagath, R. , HONGO, Jo-anne , WU, Yan
IPC分类号： C07K16/28 , A61K39/395 , A61P35/02 , C12N15/13 , C12N5/20 , C07K19/00 , G01N33/574
CPC分类号： A61K39/3955 , A61K31/69 , A61K39/395 , A61K45/06 , A61K2039/505 , C07K16/283 , C07K2317/24 , C07K2317/92 , A61K2300/00
摘要： The present invention is directed to compositions of matter useful for the treatment of hematopoietic tumor in mammals and to methods of using those compositions of matter for the same.
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公开(公告)号：EP2334331A1
公开(公告)日：2011-06-22
申请号：EP09793181.0
申请日：2009-09-30
发明人： SIEBEL, Christian, W. , WU, Yan
IPC分类号： A61K39/395 , A61P35/00 , C07K16/28
CPC分类号： C07K16/28 , A61K2039/505 , C07K16/30 , C07K16/3053 , C07K2317/21 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/92 , C07K2319/00
摘要： The invention provides anti-Notch antibodies, and in particular, antibodies that bind Notch2 NRR, and methods of using the same.
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6.发明公开RON COMPOSITIONS AND METHODS OF USE THEREOF 有权RON-ZUSAMMENSETZUNGEN UND VERFAHREN ZUR VERWENDUNG DAVON
公开(公告)号：EP2925781A1
公开(公告)日：2015-10-07
申请号：EP13802836.0
申请日：2013-11-27
发明人： EGEN, Jackson G. , HONGO, Jo-Anne , KAUDER, Steven , LAZARUS, Robert A. , SANTELL, Lydia , WU, Yan , HAZEN, Meredith , LIANG, Wei-Ching
IPC分类号： C07K16/28 , A61K39/395 , C07K14/52 , C12N5/10
CPC分类号： C07K16/40 , A61K2039/505 , C07K14/52 , C07K14/70596 , C07K16/2863 , C07K2317/55 , C07K2317/74 , C07K2317/75 , C07K2317/76 , C07K2317/92 , C07K2319/30 , C12Q1/6883 , C12Q2600/106 , C12Q2600/156 , G01N33/74 , G01N2333/71 , G01N2333/912 , G01N2800/065 , G01N2800/20 , G01N2800/52
摘要： This invention relates to RON compositions, in particular RON composition comprising a RON agonist, and methods of using the compositions for the treatment of diseases. The invention also relates to diagnosis of RON-associated or MSP-associated diseases.
摘要翻译： 本发明涉及RON组合物，特别是包含RON激动剂的RON组合物，以及使用该组合物治疗疾病的方法。 本发明还涉及RON相关或MSP相关疾病的诊断。
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公开(公告)号：EP2744824A1
公开(公告)日：2014-06-25
申请号：EP12751691.2
申请日：2012-08-16
发明人： JACKSON, Erica , SCHAEFER, Gabriele , WU, Yan
IPC分类号： C07K16/22 , A61K39/395 , A61P35/00
CPC分类号： C07K16/22 , A01K2267/0331 , A61K47/6845 , A61K2039/505 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C12N15/1135 , C12N15/1136 , C12N2310/14 , C12N2310/531 , C12N2330/50 , C12N2740/16043
摘要： The invention provides anti-neuregulin1 antibodies and methods of using the antibodies in treating diseases or disorders, such as cancer. In a particular embodiment, the anti-neuregulin1 antibodies bind to both neuregulin1α and neuregulin 1β isoforms.
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公开(公告)号：EP2582729A1
公开(公告)日：2013-04-24
申请号：EP11796485.8
申请日：2011-06-17
发明人： PEI, Lin , WU, Yan , YE, Xiaofen
CPC分类号： A61K45/06 , A61K39/39558 , A61K2039/505 , A61K2039/507 , C07K16/22 , C07K16/2863 , C07K2317/21 , C07K2317/31 , C07K2317/73 , C07K2317/76 , C07K2317/92 , A61K2300/00
摘要： The invention provides anti-Axl antibodies and methods of using the same.
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公开(公告)号：EP3086807A1
公开(公告)日：2016-11-02
申请号：EP14827379.0
申请日：2014-12-23
发明人： CHEN, Yongmei , ERNST, James , KIM, Hok Seon , SONODA, Junichiro , SPIESS, Christoph , STAWICKI, Scott , WU, Yan
IPC分类号： A61K39/395 , C07K14/71 , C07K16/18 , C07K16/28 , C07K16/46
CPC分类号： C07K16/40 , A61K2039/505 , C07K14/71 , C07K16/2863 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/33 , C07K2317/34 , C07K2317/40 , C07K2317/41 , C07K2317/51 , C07K2317/515 , C07K2317/524 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/71 , C07K2317/75 , C07K2317/92
摘要： The presently disclosed subject matter provides antibodies that bind KLB and FGFR1, and methods of using the same. In certain embodiments, an antibody of the present disclosure includes a bispecific antibody that binds to an epitope present on FGFR1 and binds to an epitope present on KLB.
摘要翻译： 目前公开的主题提供了结合KLB和FGFR1的抗体及其使用方法。 在某些实施方案中，本公开的抗体包括结合存在于FGFR1上并与KLB上存在的表位结合的双特异性抗体。
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公开(公告)号：EP3057615A2
公开(公告)日：2016-08-24
申请号：EP14790974.1
申请日：2014-10-17
发明人： STORM, Elaine , DE SAUVAGE, Frederic J. , MURRAY, Jeremy M. , NOLAND, Cameron L. , WU, Yan , TAN, Christine , HONGO, Jo-Anne , CHEN, Yongmei
IPC分类号： A61K39/395 , C07K16/18 , C07K16/28 , C07K16/30 , G01N33/574 , A61K39/00
CPC分类号： C07K16/18 , A61K39/3955 , A61K45/06 , A61K47/6843 , A61K2039/505 , C07K16/2818 , C07K16/3046 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/56 , C07K2317/75 , C07K2317/76 , C07K2317/92
摘要： Provided herein are anti-RSPO antibodies, in particular anti-RSPO2 antibodies and/or anti-RSPO3 antibodies, and methods of using the same.
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