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1.发明授权NOVEL 4-AMINO-N-HYDROXY-BENZAMIDES AS HDAC INHIBITORS FOR THE TREATMENT OF CANCER 有权NEW 4-氨基-N-羟基 - 苯甲酰胺作为HDAC抑制剂的用于癌症的治疗
公开(公告)号：EP2665706B1
公开(公告)日：2014-10-22
申请号：EP12700482.8
申请日：2012-01-18
IPC分类号： C07D207/50 , C07D401/04 , C07D403/04 , C07D403/10 , C07D413/10 , C07D471/04 , A61K31/4015 , A61K31/402 , A61K31/4025 , A61K31/407 , A61P35/00
CPC分类号： C07D207/50 , C07D401/04 , C07D403/04 , C07D403/10 , C07D413/10 , C07D471/04
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2.发明公开NOVEL 4-AMINO-N-HYDROXY-BENZAMIDES AS HDAC INHIBITORS FOR THE TREATMENT OF CANCER 有权NEW 4-氨基-N-羟基 - 苯甲酰胺作为HDAC抑制剂的用于癌症的治疗
公开(公告)号：EP2665706A1
公开(公告)日：2013-11-27
申请号：EP12700482.8
申请日：2012-01-18
IPC分类号： C07D207/50 , C07D401/04 , C07D403/04 , C07D403/10 , C07D413/10 , C07D471/04 , A61K31/4015 , A61K31/402 , A61K31/4025 , A61K31/407 , A61P35/00
CPC分类号： C07D207/50 , C07D401/04 , C07D403/04 , C07D403/10 , C07D413/10 , C07D471/04
摘要： The present invention provides hdac inhibitors of formula (I), or pharmaceutically acceptable salts, esters or stereoisomers thereof, wherein R
1 to R
4 , A and Y have the meanings given herein, as well as methods for making those compounds and their use as medicament, in particular as medicament for the treatment of cancer.-
3.发明公开6-AMINO ACID HETEROARYLDIHYDROPYRIMIDINES FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS INFECTION 有权6-氨基HETEROARYLDIHYDROPYRIMIDINE用于治疗和预防乙型肝炎病毒INFECTION-
公开(公告)号：EP2892893A1
公开(公告)日：2015-07-15
申请号：EP13763201.4
申请日：2013-09-06
发明人： GUO, Lei , HU, Taishan , HU, Yimin , KOCER, Buelent , LIN, Xianfeng , LIU, Haixia , MAYWEG, Alexander V. , QIU, Zongxing , SHEN, Hong , TANG, Guozhi , WANG, Lisha , WU, Guolong , YAN, Shixiang , ZHANG, Weixing , ZHOU, Mingwei , ZHU, Wei
IPC分类号： C07D401/14 , C07D413/14 , C07D403/06 , C07D409/14 , C07D417/14 , A61K31/506 , A61K31/5355 , A61P31/20
CPC分类号： C07D417/14 , A61K31/506 , A61K31/5377 , A61K31/541 , A61K45/06 , C07D401/14 , C07D403/06 , C07D409/14 , C07D413/14 , A61K2300/00
摘要： The invention provides novel compounds having the general formula:, wherein R
1 , R
2 , R
3 , R
4 and A are as described herein, compositions including the compounds and methods of using the compounds.-
4.发明公开NOVEL 4-METHYL-DIHYDROPYRIMIDINES FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS INFECTION 有权新的4-甲基 - 二氢嘧啶可用于治疗和预防乙型肝炎病毒感染的
公开(公告)号：EP2831060A1
公开(公告)日：2015-02-04
申请号：EP13712263.6
申请日：2013-03-26
发明人： GUO, Lei , LIN, Xianfeng , LIU, Haixia , QIU, Zongxing , SHEN, Hong , TANG, Guozhi , WU, Guolong , ZHANG, Weixing , ZHU, Wei
IPC分类号： C07D401/14 , C07D413/14 , A61K31/506 , C07D403/14 , C07D409/14 , C07D417/04 , C07D417/14 , A61P31/12
CPC分类号： C07D401/14 , C07D403/14 , C07D409/14 , C07D413/14 , C07D417/04 , C07D417/14
摘要： The invention provides novel compounds having the general formula (I): wherein R
1 , R
2 , R
3 , R
4 , R
5 , M and X are as described herein, compositions including the compounds and methods of using the compounds.-
5.发明授权NOVEL 4-METHYL-DIHYDROPYRIMIDINES FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS INFECTION 有权新的4-甲基 - 二氢嘧啶可用于治疗和预防乙型肝炎病毒感染的
公开(公告)号：EP2831060B1
公开(公告)日：2016-05-04
申请号：EP13712263.6
申请日：2013-03-26
发明人： GUO, Lei , LIN, Xianfeng , LIU, Haixia , QIU, Zongxing , SHEN, Hong , TANG, Guozhi , WU, Guolong , ZHANG, Weixing , ZHU, Wei
IPC分类号： C07D401/14 , C07D413/14 , A61K31/506 , C07D403/14 , C07D409/14 , C07D417/04 , C07D417/14 , A61P31/12
CPC分类号： C07D401/14 , C07D403/14 , C07D409/14 , C07D413/14 , C07D417/04 , C07D417/14
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6.发明公开NEW OCTAHYDRO-PYRROLO[3,4-C]-PYRROLE DERIVATIVES AND ANALOGS THEREOF AS AUTOTAXIN INHIBITORS 审中-公开NEER OCAHYDRO-PYRROLO [3,4-C] -PYRROL-DERIVATE UND ANALOGA DAVON ALS AUTOTAXIN-INHIBITOREN
公开(公告)号：EP2970256A1
公开(公告)日：2016-01-20
申请号：EP14708891.8
申请日：2014-03-11
发明人： HERT, Jérôme , HUNZIKER, Daniel , MATTEI, Patrizio , MAUSER, Harald , TANG, Guozhi , WANG, Lisha
IPC分类号： C07D471/04 , C07D487/04 , A61K31/437 , A61K31/407 , A61K31/5517 , A61P29/00
CPC分类号： C07D487/04 , C07D471/04
摘要： The invention provides novel compounds having the general formula (I) wherein R1, Y, A, W, R2, m, n, p and q are as described herein, compositions including the compounds and methods of using the compounds.
摘要翻译： 本发明提供具有通式（I）的新化合物，其中R 1，Y，A，W，R 2，m，n，p和q如本文所述，包括该化合物的组合物和使用该化合物的方法。
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7.发明公开NEW BICYCLIC DERIVATIVES 审中-公开六氢[3,4-c]吡咯衍生物和相关化合物作为自分泌运动因子（ATX）抑制剂和ASLYSOPHOSPHATINSÄURE（LPA）的生产用于治疗例如抑制剂 肾脏疾病
公开(公告)号：EP2900669A1
公开(公告)日：2015-08-05
申请号：EP13766056.9
申请日：2013-09-23
发明人： HERT, Jérôme , HUNZIKER, Daniel , MATTEI, Patrizio , MAUSER, Harald , TANG, Guozhi , WANG, Lisha
IPC分类号： C07D487/04 , A61K31/407 , A61P13/12 , A61P1/16 , A61P25/00 , A61P37/06
CPC分类号： C07D471/04 , C07D403/12 , C07D413/12 , C07D487/04 , C07D519/00
摘要： The invention provides novel compounds having the general formula (I) wherein R1, Y, A, W, R2, m, n, p and q are as described herein, compositions including the compounds and methods of using the compounds.
摘要翻译： worin R1，Y，A，W，R 2，M，N，p和q是如描述于，组合物，包括的化合物和使用所述化合物的方法。
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公开(公告)号：EP2613775B1
公开(公告)日：2014-07-30
申请号：EP11757581.1
申请日：2011-09-05
IPC分类号： A61K31/16 , A61K31/352 , A61K31/47 , C07C259/10 , C07C311/07 , C07C311/20 , C07D213/74 , C07D215/48 , C07D239/30 , C07D239/42 , C07D239/56 , C07D311/04 , A61P25/00
CPC分类号： C07C259/10 , C07C311/07 , C07C311/20 , C07C311/29 , C07C2602/10 , C07D213/56 , C07D213/71 , C07D213/74 , C07D215/48 , C07D239/42 , C07D239/47 , C07D401/04 , C07D401/14 , C07D405/14
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公开(公告)号：EP2613775A1
公开(公告)日：2013-07-17
申请号：EP11757581.1
申请日：2011-09-05
IPC分类号： A61K31/16 , A61K31/352 , A61K31/47 , C07C259/10 , C07C311/07 , C07C311/20 , C07D213/74 , C07D215/48 , C07D239/30 , C07D239/42 , C07D239/56 , C07D311/04 , A61P25/00
CPC分类号： C07C259/10 , C07C311/07 , C07C311/20 , C07C311/29 , C07C2602/10 , C07D213/56 , C07D213/71 , C07D213/74 , C07D215/48 , C07D239/42 , C07D239/47 , C07D401/04 , C07D401/14 , C07D405/14
摘要： The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt, ester or stereoisomer thereof, wherein R1 to R3 and X have the significances given herein. The present invention is also directed to processes for making said compounds and uses of said compounds, in particular their use as medicaments, more particularly their use as medicaments in the treatment of cancer.
摘要翻译： 本发明提供式（I）化合物或其药学上可接受的盐，酯或立体异构体，其中R1至R3和X具有本文给出的含义。 本发明还涉及制备所述化合物的方法和所述化合物的用途，特别是其用作药物，更具体地说，其用作治疗癌症中的药物。
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