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公开(公告)号：EP3036230A1
公开(公告)日：2016-06-29
申请号：EP14755806.8
申请日：2014-08-22
发明人： BLAQUIERE, Nicole , BURCH, Jason , CASTANEDO, Georgette , FENG, Jianwen A. , HU, Baihua , STABEN, Steven , WU, Guosheng , YUEN, Po-wai
IPC分类号： C07D401/14 , C07D413/14 , C07D401/10 , C07D403/10 , C07D403/14 , C07D413/10 , C07D471/04 , C07D487/04 , C07D495/04 , C07D417/10 , C07D491/048 , C07D491/052 , C07D513/04 , A61K31/416 , A61K31/4155
CPC分类号： C07D513/04 , C07D401/10 , C07D401/14 , C07D403/10 , C07D403/14 , C07D413/10 , C07D413/14 , C07D417/10 , C07D471/04 , C07D487/04 , C07D491/048 , C07D491/052 , C07D495/04
摘要： The invention relates to compounds of Formula (0): wherein Q, A
1 -A
8 , R
4 and R
5 and each has the meaning as described herein. Compounds of Formula (0) and pharmaceutical compositions thereof are useful in the treatment of diseases and disorders in which undesired or over- activation of NF-kB signaling is observed.摘要翻译： 本发明涉及式（O）的化合物：其中Q，A1-A8，R4和R5各自具有如本文所述的含义。 式（0）的化合物及其药物组合物可用于治疗其中观察到NF-kB信号传导的不期望或过度活化的疾病和病症。
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公开(公告)号：EP3036229A1
公开(公告)日：2016-06-29
申请号：EP14755363.0
申请日：2014-08-22
发明人： BLAQUIERE, Nicole , BURCH, Jason , CASTANEDO, Georgette , FENG, Jianwen A. , HU, Baihua , LIN, Xingyu , STABEN, Steven , WU, Guosheng , YUEN, Po-wai
IPC分类号： C07D401/14 , C07D405/14 , C07D413/14 , C07D401/10 , C07D403/10 , C07D403/14 , C07D409/14 , C07D413/10 , C07D417/14 , C07D471/04 , C07D487/04 , C07D491/107 , C07D495/04 , A61K31/439 , A61P29/00
CPC分类号： C07D401/10 , A61K31/395 , C07D401/14 , C07D403/10 , C07D403/14 , C07D405/10 , C07D405/14 , C07D409/14 , C07D413/10 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04 , C07D491/048 , C07D491/107 , C07D495/04 , C07D495/06
摘要： wherein A1-A8, R4 and R5 each has the meaning as described herein. Compounds of Formula (0) and pharmaceutical compositions thereof are useful in the treatment of diseases and disorders in which undesired or over-activation of NF-kB signaling is observed.
摘要翻译： 本发明涉及式（O）的化合物：其中A1-A8，R4和R5各自具有如本文所述的含义。 式（0）的化合物及其药物组合物可用于治疗其中观察到NF-kB信号传导的不期望或过度活化的疾病和病症。
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公开(公告)号：EP2882718A1
公开(公告)日：2015-06-17
申请号：EP13827574.8
申请日：2013-08-09
发明人： BROOKFIELD, Frederick , BURCH, Jason , GOLDSMITH, Richard A. , HU, Baihua , LAU, Kevin Hon Luen , MACKINNON, Colin H. , ORTWINE, Daniel Fred , PEI, Zhonghua , WU, Guosheng , YUEN, Po-wai , ZHANG, Yamin
IPC分类号： C07D231/56 , A61K31/416 , A61P37/00
CPC分类号： C07D403/12 , C07D401/14 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D487/10 , C07D491/044 , C07D491/10 , C07D491/107 , C07D495/10 , Y02P20/582
摘要： Provided herein are compounds of formula (AA): N N H HN O N N R R 6 A (R a ) p, (AA) stereoisomers or a pharmaceutically acceptable salt thereof, wherein A, R a, p, R and R 6 are defined herein, compositions including the compounds and methods of manufacturing and using the compounds for the treatment of diseases.
摘要翻译： 本文提供了式（AA）的化合物：其中A，R a，p，R和R 6如本文定义的组合物，其包含 该化合物以及制造和使用该化合物治疗疾病的方法。
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