公开(公告)号：EP0882718A4

公开(公告)日：1999-08-04

申请号：EP96943331

申请日：1996-12-27

申请人： FUJISAWA PHARMACEUTICAL CO

发明人： YAMASAKI NORITSUGU ,  IMOTO TAKAFUMI ,  MURAI YOSHIYUKI ,  HIRAMURA TAKAHIRO ,  OKU TERUO ,  SAWADA KOUZOU

IPC分类号： A61K31/4184 ,  A61K31/427 ,  A61K31/433 ,  A61K31/4427 ,  A61K31/443 ,  A61K31/4439 ,  A61K31/4709 ,  A61K31/5355 ,  A61K31/5377 ,  A61K31/541 ,  A61K31/55 ,  A61P1/00 ,  A61P3/06 ,  A61P3/10 ,  A61P9/00 ,  A61P9/10 ,  A61P9/12 ,  A61P13/12 ,  A61P15/10 ,  A61P17/00 ,  A61P27/06 ,  A61P27/16 ,  A61P43/00 ,  C07D209/08 ,  C07D235/08 ,  C07D401/06 ,  C07D401/10 ,  C07D401/12 ,  C07D403/06 ,  C07D403/12 ,  C07D405/06 ,  C07D405/12 ,  C07D405/14 ,  C07D417/06 ,  C07D417/10 ,  C07D417/12 ,  C07D417/14 ,  C07D235/10 ,  C07D235/22 ,  C07D235/24 ,  C07D235/26 ,  C07D235/28 ,  C07D235/30

CPC分类号： C07D401/06 ,  C07D209/08 ,  C07D235/08 ,  C07D401/12 ,  C07D403/06 ,  C07D403/12 ,  C07D405/06 ,  C07D405/12 ,  C07D417/06 ,  C07D417/10 ,  C07D417/12 ,  C07D417/14

摘要： Novel benzimidazole derivatives represented by general formula (I) or pharmaceutically acceptable salts thereof wherein R3 represents carboxy, esterified carboxy, carboxamide, amino, amido or sulfonyl. Because of having hypoglycemic or PDE5 inhibitory effects, these compounds or salts thereof are useful as remedies for impaired glucose tolerance, diabetes, complications of diabetes, insulin resistant syndrome, hyperlipidemia, atherosclerosis, cardiovascular diseases, hyperglycemia, hypertension, angina pectoris, pulmonary hypertension, congestive heart failure, glomerular diseases, tubular interstitial diseases, renal failure, angiostenosis, peripheral vascular disease, apoplexy, chronic reversible obstructive diseases, allergic rhinitis, urticaria, glaucoma, diseases characterized by abnormality in intestinal motility, sexual impotence, nephritis, cancerous cachexia, or post-PCTA reconstriction.