公开(公告)号：EP1142879A4

公开(公告)日：2002-02-06

申请号：EP99959929

申请日：1999-12-20

申请人： FUJISAWA PHARMACEUTICAL CO

发明人： KAYAKIRI HIROSHI ,  ABE YOSHITO ,  HAMASHIMA HITOSHI ,  SAWADA HITOSHI ,  ISHIBASHI NAOKI ,  SETOI HIROYUKI ,  OKU TERUO ,  YAMASAKI NORITSUGU ,  IMOTO TAKAFUMI ,  HIRAMURA TAKAHIRO

IPC分类号： A61K31/4174 ,  A61K31/4178 ,  A61P3/10 ,  A61P43/00 ,  C07D233/54 ,  C07D233/64 ,  C07D233/68 ,  C07D233/90 ,  C07D233/94 ,  C07D401/06 ,  C07D405/10 ,  C07D409/10 ,  C07D409/12

CPC分类号： C07D233/64 ,  C07D233/90 ,  C07D233/94 ,  C07D405/10 ,  C07D409/10 ,  C07D409/12

摘要： Imidazole compounds represented by general formula (I) and salts thereof and medicinal compositions containing the same. These compounds are useful in treating diseases which can be treated based on the hypoglycemic effect thereof, and diseases which can be treated based on the cGMP-PDE inhibitory effect, smooth muscular relaxant effect, bronchodilating effect, vasodilating effect, smooth muscle cell regulatory effect and allergy-inhibitory effects thereof, wherein each symbol is as defined in the description.

公开(公告)号：EP1136492A4

公开(公告)日：2002-03-27

申请号：EP99973290

申请日：1999-12-01

申请人： FUJISAWA PHARMACEUTICAL CO

发明人： KAYAKIRI HIROSHI ,  ABE YOSHITO ,  HAMASHIMA HITOSHI ,  SAWADA HITOSHI ,  ISHIBASHI NAOKI ,  SETOI HIROYUKI ,  OKU TERUO ,  YAMASAKI NORITSUGU ,  IMOTO TAKAFUMI ,  HIRAMURA TAKAHIRO

IPC分类号： A61P43/00 ,  C07D471/04 ,  A61K31/437 ,  A61P3/06 ,  A61P3/10 ,  A61P9/08 ,  A61P11/08 ,  A61P37/08

CPC分类号： C07D471/04

摘要： Sulfonamide compounds represented by general formula (I), or salts thereof; and drug compositions containing the same (wherein each symbol is as defined in the description). These compounds serve as preventive or therapeutic agents efficacious against diseases which can be cured through decrease in blood sugar level and those which can be cured through inhibition of cGMP-PDE, relaxation of smooth muscle, bronchodilation, vasodilation, inhibition of smooth muscle fiber, or inhibition of allergy.

公开(公告)号：EP1142880A4

公开(公告)日：2002-02-27

申请号：EP99961320

申请日：1999-12-22

申请人： FUJISAWA PHARMACEUTICAL CO

发明人： YAMASAKI NORITSUGU ,  IMOTO TAKAFUMI ,  HIRAMURA TAKAHIRO ,  KAWAUCHI MIHO ,  OKU TERUO ,  KAYAKIRI HIROSHI ,  SAWADA HITOSHI ,  ABE YOSHITO ,  HAMASHIMA HITOSHI ,  ISHIBASHI NAOKI ,  SETOI HIROYUKI

IPC分类号： A61P3/06 ,  A61P3/10 ,  A61P9/00 ,  A61P9/10 ,  A61P15/10 ,  A61P27/06 ,  C07D235/08 ,  C07D235/12 ,  C07D405/10 ,  C07D405/12 ,  C07D409/10 ,  C07D409/12 ,  C07D409/14 ,  A61K31/4184 ,  A61K31/5377

CPC分类号： C07D405/10 ,  C07D235/08 ,  C07D235/12 ,  C07D405/12 ,  C07D409/10 ,  C07D409/12 ,  C07D409/14

摘要： Novel benzimidazole derivatives represented by general formula (I) or salts thereof, which have hypoglycemic and PDE5-inhibiting effects and are therefore useful as drugs; in formula (I) R1 is lower alkyl which may be substituted with lower alkyloxy; R2 is hydrogen, halogeno, C1-C8 alkyl, aryl, or the like; R3 is lower alkyl, lower alkenyl, aryl, lower alkylaryl, aryl-substituted lower alkenyl, halothienyl, lower alkylamino or aryl lower alkylamino; A is a benzene ring, a naphthalene ring, or a pyridine ring; and X is halogeno.