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    Anti-FR-900506 substance antibodies and highly-sensitive enzyme immunoassay method
    4.
    发明公开
    Anti-FR-900506 substance antibodies and highly-sensitive enzyme immunoassay method 失效
    抗FR-900506-Stoffe-AntikörperundhöchstempfindlichesEnzym-Immunoassay-Verfahren。

    公开(公告)号：EP0293892A2

    公开(公告)日：1988-12-07

    申请号：EP88108837.1

    申请日：1988-06-02

    申请人： FUJISAWA PHARMACEUTICAL CO., LTD.

    发明人： Niwa, Mineo ,  Tamura, Kouichi ,  Kaizu, Tsutomu ,  Kobayashi, Masakazu

    IPC分类号： C12P21/00 ,  G01N33/543

    CPC分类号： C07D498/18 ,  C07K16/1292 ,  C12P17/188 ,  C12P19/44 ,  Y10S435/81 ,  Y10S436/808 ,  Y10S530/808 ,  Y10S530/809 ,  Y10S530/815 ,  Y10S530/864 ,  Y10S530/868

    摘要： An antibody capable of recognizing antigenic determinant(s) located on the FR-900506 substance, a highly-sensitive enzyme immunoassay method for the FR-900506 substance, which comprises immobilizing an antibody capable of recognizing antigenic determinant(s) located on the FR-900506 substance, allowing the FR-900506 substance contained in a sample and an enzyme-labeled FR-900506 substance to react competitively with the immobilized antibody and detect­ing the enzyme-labeled substance bound to the immobilized antibody, and a test kit for the detection of the FR-900506 substance. The invention also comprises a process for preparation of the monoclonal antibody of claim 4, which comprises culturing a hybridoma cell line capable of producing anti-FR-900506 substance antibody and isolating it from the cultured broth.

    摘要翻译： 能够识别位于FR-900506物质上的抗原决定簇的抗体，FR-900506物质的高度灵敏的酶免疫测定方法，该方法包括将能够识别位于FR-900506物质上的抗原决定簇的抗体固定在FR- 900506物质，允许样品中所含的FR-900506物质和酶标记的FR-900506物质与固定的抗体竞争性地反应并检测与固定的抗体结合的酶标记物质，以及检测试剂盒 FR-900506物质。 本发明还包括权利要求4的单克隆抗体的制备方法，其包括培养能产生抗FR-900506物质抗体的杂交瘤细胞系，并从培养的培养液中分离。

    A new antimicrobial compound,WF11605,derivatives therof and processes for preparing the same
    7.
    发明公开
    A new antimicrobial compound,WF11605,derivatives therof and processes for preparing the same 失效
    Antimikrobielle Verbindung，WF 11605，derenAbkömmlingeund Verfahren zu deren Herstellung。

    公开(公告)号：EP0330334A1

    公开(公告)日：1989-08-30

    申请号：EP89301203.9

    申请日：1989-02-08

    申请人： FUJISAWA PHARMACEUTICAL CO., LTD.

    发明人： Okamoto, Masanori ,  Tsujii, Eisaku ,  Kaizu, Tsutomu ,  Hatanaka, Hiroshi ,  Okuhara, Masakuni ,  Sawada, Kozo ,  Tanaka, Hirokazu

    IPC分类号： C07D309/10 ,  C12P17/06 ,  A61K31/71 ,  C07C62/38 ,  C07J63/00

    CPC分类号： C07J63/008 ,  C12P17/06

    摘要： Compounds of the formula:
    wherein R¹ is hydrogen or acyl,
    R² is hydrogen or
    in which
    R⁴, R⁵, R⁶ and R⁷ are hydrogen or acyl,
    R³ is carboxy or protected carboxy,
    and pharmaceutically acceptable salts thereof.
    One of these compounds, designated WF11605, can be prepared by culturing a WF11605 - producing microorganism, such as Agonomycetes strain F-11605, in an aqueous nutrient medium under aerobic conditions. Processes are also provided for the preparation of various synthetic derivatives of WF11605.
    The compound WF11605 and its derivatives possess antimicrobial activity and are useful as antibiotics and as agents for the prevention and treatment of diseases caused by Leukotriene B₄ (LTB₄). Pharmaceutical compositions containing these compounds are described.

    摘要翻译： 其中R 1是氢或酰基，R 2是氢或CHEM，其中R 4，R 5，R 6和R 7分别是 氢或酰基，R 3是羧基或被保护的羧基，及其药学上可接受的盐。 这些化合物中的一种，称为WF11605，可以通过在有氧条件下在水性营养培养基中培养产生WF11605的微生物，例如Agiogretes菌株F-11605来制备。 还提供了制备WF11605的各种合成衍生物的方法。 化合物WF11605及其衍生物具有抗微生物活性，可用作抗生素和预防和治疗由白三烯B4（LTB4）引起的疾病的药剂。 描述含有这些化合物的药物组合物。