利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

20 条记录 (耗时 0.013 秒)

    Synisomer cephalosporin compounds and processes for their preparation
    3.
    发明公开
    Synisomer cephalosporin compounds and processes for their preparation 失效
    Synisomer von Cephalosporinverbindungen und Verfahren zu ihrer Herstellung。

    公开(公告)号：EP0036510A2

    公开(公告)日：1981-09-30

    申请号：EP81101456.2

    申请日：1981-02-28

    申请人： FUJISAWA PHARMACEUTICAL CO., LTD.

    发明人： Ueda, Ikuo ,  Kobayashi, Masakazu

    IPC分类号： C07D501/20 ,  C07D501/14

    CPC分类号： C07D277/587

    摘要： A syn compound of the formula:
    wherein

    R' is an aliphatic hydrocarbon group which may have suitable substituent(s),
    R 2 is carboxy or protected carboxy,
    R 5 is hydrogen or hydroxy,
    X 1 and X 2 are each halogen, and
    the dotted line represents cepham or cephem nucleus,
    or a salt thereof, and processes for their preparation. The invention also relates to intermediates of the formula
    and their preparation and to processes for preparing known cephem-compounds and their intermediates.

    摘要翻译： 下式的顺式化合物：其中... R 1是可具有合适取代基的脂族烃基，R 2是羧基或被保护的羧基，R 3是氢 或羟基，X 1和X 2各自为卤素，虚线代表头孢烯或头孢烯核，或其盐，及其制备方法本发明还涉及下式的中间体： ...及其制备方法以及制备已知的cephamen化合物及其中间体的方法。

    3,7-Disubstituted-2- or -3-cephem-4-carboxylic acid compounds, pharmaceutical compositions containing them and processes for the preparation thereof
    4.
    发明公开
    3,7-Disubstituted-2- or -3-cephem-4-carboxylic acid compounds, pharmaceutical compositions containing them and processes for the preparation thereof 失效
    3,7-二取代的2或3-头孢烯-4-羧酸化合物，含有它们的它们的制备方法的药物组合物。

    公开(公告)号：EP0010313A1

    公开(公告)日：1980-04-30

    申请号：EP79104084.3

    申请日：1979-10-22

    申请人： FUJISAWA PHARMACEUTICAL CO., LTD.

    发明人： Ueda, Ikuo ,  Kobayashi, Masakazu ,  Yamada, Hisashi ,  Ono, Hiroki

    IPC分类号： C07D501/18 ,  C07D501/26 ,  C07D501/60 ,  A61K31/545

    CPC分类号： C07D501/14

    摘要： New 3,7-disubstituted-2 or 3-cephem-4-carboxylic acid compounds of the formula:
    wherein

    R 1 is amino or a substituted amino group;
    R 2 is carboxy or a protected carboxy group;
    the group of the formula:
    is di(lower)alkylamino (lower)alkylamino, a N-containing heterocyclic (lower)alkylamino group which may have suitable substituent(s), a heterocyclic group containing 2 to 4 nitrogen atoms which may have suitable substituent(s) or hydroxypiperidino; and X is -S- or
    e.g. 7-[2-methoxyimino-2- (2-aminothiazol-4-yl) acetamido] -3-(4-methyl-1-piperazinyl) carbonyloxymethyl-3-cephem -4-carboxylic acid (syn isomer); pharmaceutically acceptablesalts thereof; and processes for their preparation. The invention also relates to pharmaceutical compositions comprising, as an effective ingredient, the above compounds in association with a pharmaceutically acceptable; substantially nontoxic carrier or excipient; and to a process for their preparation.

    摘要翻译： 新的3,7-二取代的2或下式的3-头孢烯-4-羧酸化合物：... ... worin ...... [R <1>被氨基或一substituiertem氨基; ... [R <2>是羧基或一个 被保护的羧基基团; ...的下式基团：... ...被二（低级）烷基氨基（低级）烷基胺基，可具有适宜取代基（或多个）含N杂环（低级）烷基氨基，杂环基包含 2可具有合适的取代基（一个或多个）或羟基哌啶子4个氮原子; 和X为-S-或0; ... S- E.G. 7-〔2-甲氧基亚氨基-2-（2-氨基噻唑-4-基）乙酰氨基] -3-（4-甲基-1-哌嗪基）羰氧基甲基-3-头孢烯-4-羧酸（顺式异构体）; 其药学上可接受的盐; 和它们的制备方法。 因此，本发明涉及药物组合物，其包含作为有效的成分，在关联上述化合物与药学上可接受的，无毒的载体或赋形剂实质上; 并到它们的制备方法。

    Intermediate compounds for preparing cephem compounds and processes for their preparation
    8.
    发明公开
    Intermediate compounds for preparing cephem compounds and processes for their preparation 失效
    制备化合物的中间体化合物及其制备方法

    公开(公告)号：EP0096903A3

    公开(公告)日：1984-02-01

    申请号：EP83106851

    申请日：1981-02-28

    申请人： FUJISAWA PHARMACEUTICAL CO., LTD.

    发明人： Ueda, Ikuo ,  Kobayashi, Masakazu

    IPC分类号： C07C131/00 ,  C07D277/38

    CPC分类号： C07D277/587

    摘要： The invention relates to intermediates of the formula
    wherein
    R 1 is C 1 to C 6 alkyl R 4 is carboxy or protected carboxy and X 1 and X 2 are each halogen, or a salt thereof, and to processes for their preparation.

    摘要翻译： 下式的顺式化合物：其中... R 1是可具有合适取代基的脂族烃基，R 2是羧基或被保护的羧基，R 3是氢 或羟基，X 1和X 2各自为卤素，虚线代表头孢烯或头孢烯核，或其盐，及其制备方法本发明还涉及下式的中间体： ...及其制备方法以及制备已知的cephamen化合物及其中间体的方法。

    Anti-FR-900506 substance antibodies and highly-sensitive enzyme immunoassay method
    10.
    发明公开
    Anti-FR-900506 substance antibodies and highly-sensitive enzyme immunoassay method 失效
    抗FR-900506-Stoffe-AntikörperundhöchstempfindlichesEnzym-Immunoassay-Verfahren。

    公开(公告)号：EP0293892A2

    公开(公告)日：1988-12-07

    申请号：EP88108837.1

    申请日：1988-06-02

    申请人： FUJISAWA PHARMACEUTICAL CO., LTD.

    发明人： Niwa, Mineo ,  Tamura, Kouichi ,  Kaizu, Tsutomu ,  Kobayashi, Masakazu

    IPC分类号： C12P21/00 ,  G01N33/543

    CPC分类号： C07D498/18 ,  C07K16/1292 ,  C12P17/188 ,  C12P19/44 ,  Y10S435/81 ,  Y10S436/808 ,  Y10S530/808 ,  Y10S530/809 ,  Y10S530/815 ,  Y10S530/864 ,  Y10S530/868

    摘要： An antibody capable of recognizing antigenic determinant(s) located on the FR-900506 substance, a highly-sensitive enzyme immunoassay method for the FR-900506 substance, which comprises immobilizing an antibody capable of recognizing antigenic determinant(s) located on the FR-900506 substance, allowing the FR-900506 substance contained in a sample and an enzyme-labeled FR-900506 substance to react competitively with the immobilized antibody and detect­ing the enzyme-labeled substance bound to the immobilized antibody, and a test kit for the detection of the FR-900506 substance. The invention also comprises a process for preparation of the monoclonal antibody of claim 4, which comprises culturing a hybridoma cell line capable of producing anti-FR-900506 substance antibody and isolating it from the cultured broth.

    摘要翻译： 能够识别位于FR-900506物质上的抗原决定簇的抗体，FR-900506物质的高度灵敏的酶免疫测定方法，该方法包括将能够识别位于FR-900506物质上的抗原决定簇的抗体固定在FR- 900506物质，允许样品中所含的FR-900506物质和酶标记的FR-900506物质与固定的抗体竞争性地反应并检测与固定的抗体结合的酶标记物质，以及检测试剂盒 FR-900506物质。 本发明还包括权利要求4的单克隆抗体的制备方法，其包括培养能产生抗FR-900506物质抗体的杂交瘤细胞系，并从培养的培养液中分离。