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公开(公告)号：EP0736018B1
公开(公告)日：2000-07-05
申请号：EP95902969.5
申请日：1994-12-16
发明人： TANIGUCHI, Kiyoshi , NAGANO, Masanobu , HATTORI, Kouji , TSUBAKI, Kazunori , OKITSU, Osamu , TABUCHI, Seiichiro
IPC分类号： C07D263/32 , A61K31/42
CPC分类号： C07D263/32
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公开(公告)号：EP0934282A1
公开(公告)日：1999-08-11
申请号：EP97941281.0
申请日：1997-09-29
CPC分类号： C07K5/0821 , A61K38/00 , C07D243/14 , C07D243/18 , C07K5/0205 , C07K5/06139
摘要： Benzodiazepine derivatives of formula (I) wherein R2 is alkyl or cycloalkyl-alkyl when R4 is hydrogen, or R2 is a variety of specified groups when R4 is alkyl, halogen or dialkylamino, are useful as cholecystokinin antagonists.
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公开(公告)号：EP0736018A1
公开(公告)日：1996-10-09
申请号：EP95902969.0
申请日：1994-12-16
发明人： TANIGUCHI, Kiyoshi , NAGANO, Masanobu , HATTORI, Kouji , TSUBAKI, Kazunori , OKITSU, Osamu , TABUCHI, Seiichiro
CPC分类号： C07D263/32
摘要： Heterocyclic compounds of formula (I) wherein R1 is carboxy or protected carboxy, R2 is aryl which may have suitable substituent(s), R3 is aryl which may have suitable substituent(s), A1 is lower alkylene, A2 is bond or lower alkylene and -Q- is (II), etc., and pharmaceutically acceptable salts thereof which are useful as a medicament.
摘要翻译： 其中R 1为羧基或被保护的羧基的式（I）杂环化合物，R 2为可具有合适取代基的芳基，R 3为可具有合适取代基的芳基，A 1为低级亚烷基，A 2为键或低级亚烷基 和-Q-是（II）等，及其药学上可接受的盐，它们可用作药物。
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公开(公告)号：EP0842161B1
公开(公告)日：2002-09-18
申请号：EP96924137.1
申请日：1996-07-18
IPC分类号： C07D263/32 , A61K31/42 , C07D413/04
CPC分类号： C07D263/32 , C07D413/04
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5.发明授权NAPHTHALENE DERIVATIVES AS PROSTAGLANDIN I2 AGONISTS 失效NAPHTALEN-DERIVATE ALS PROSTAGLANDIN I2 AGONISTEN
公开(公告)号：EP0749424B1
公开(公告)日：2001-09-12
申请号：EP95910763.2
申请日：1995-03-08
发明人： TANIGUCHI, Kiyoshi , NAGANO, Masanobu , HATTORI, Kouji , TSUBAKI, Kazunori , OKITSU, Osamu , TABUCHI, Seiichiro
IPC分类号： C07D213/64 , C07D237/14 , C07C271/28 , C07C235/40 , A61K31/44 , A61K31/50 , A61K31/16
CPC分类号： C07D213/64 , C07C271/12 , C07C271/28 , C07C281/02 , C07C2602/10 , C07D237/14 , C07D303/16
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公开(公告)号：EP0842161A1
公开(公告)日：1998-05-20
申请号：EP96924137.0
申请日：1996-07-18
CPC分类号： C07D263/32 , C07D413/04
摘要： Heterocyclic compounds of formula (I), wherein R1 is carboxy or protected carboxy, R2 is aryl which may have suitable substituent(s), R3 is aryl which may have suitable substituent(s), R4 is hydrogen, lower alkyl, hydroxy or aryl, A1 is lower alkylene, (a) is (b), etc., -A3- is (c), etc. and n is 0 or 1, and pharmaceutically acceptable salts thereof which are useful as a medicament.
摘要翻译： 下式的杂环化合物：其中R 1为羧基或酯化羧基，R 2和R 3为苯基或（C 1 -C 6）烷基苯基，A 1为（C 1 -C 6）亚烷基 ，n为0或1，用于治疗或预防动脉阻塞，肝炎，肝功能不全，经皮腔内冠状动脉血管成形术，动脉硬化，脑血管病或缺血性心脏病之后的再狭窄。
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公开(公告)号：EP0804425A2
公开(公告)日：1997-11-05
申请号：EP95926512.0
申请日：1995-07-27
发明人： SATO, Yoshinari , SAKANE, Kazuo , TABUCHI, Seiichiro , MITSUI, Hitoshi , KATSUMI, Ikuyo , SATOH, Yuichi
IPC分类号： C07D243 , A61K31 , A61P1 , A61P25 , C07D401 , C07D403 , C07D405 , C07D409 , C07D413 , C07D417 , C07D487
CPC分类号： C07D243/24
摘要： Benzodiazepine derivatives of formula (I) wherein R1 is aryl which may have one or more suitable substituent(s), R2 is C3-C8 cycloalkyl which may have one or more suitable substituent(s), A is lower alkylene, R3 is a heterocyclic group selected from the group consisting of tetrahydrofuryl, dioxolanyl, furyl, thienyl, isoxazolyl, pyridyl, benzimidazolyl, benzothiazolyl, benzoxazolyl, benzopyranyl, quinolyl, isoquinolyl, tetrahydroisoquinolyl, benzothienyl and benzofuryl, each of which may have one or more suitable substituent(s), or a pharmaceutically acceptable salt thereof, which are useful as a medicament.
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公开(公告)号：EP0749424A1
公开(公告)日：1996-12-27
申请号：EP95910763.0
申请日：1995-03-08
发明人： TANIGUCHI, Kiyoshi , NAGANO, Masanobu , HATTORI, Kouji , TSUBAKI, Kazunori , OKITSU, Osamu , TABUCHI, Seiichiro
IPC分类号： A61K31 , A61P7 , A61P9 , A61P43 , C07C69 , C07C235 , C07C271 , C07C281 , C07D213 , C07D237 , C07D303
CPC分类号： C07D213/64 , C07C271/12 , C07C271/28 , C07C281/02 , C07C2602/10 , C07D237/14 , C07D303/16
摘要： A compound of formula (I) wherein, R1 is carboxy or protected carboxy; R2 is hydrogen, hydroxy or protected hydroxy; R3 is hydrogen, hydroxy, protected hydroxy, etc.; R4 is hydrogen or halogen; A1 is lower alkylene; A2 is bond or lower alkylene; -R5 is (a) (in which R6 is mono(or di or tri)aryl(lower)alkyl and Z is N or CH), etc.; and (b) is (c), etc.; and a pharmaceutically acceptable salt thereof which are useful as medicaments.
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