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    4,5-DIARYLOXAZOLE DERIVATIVES
    2.
    发明公开
    4,5-DIARYLOXAZOLE DERIVATIVES 失效
    4,5-DIARYLOXAZOLE衍生物

    公开(公告)号：EP0736018A1

    公开(公告)日：1996-10-09

    申请号：EP95902969.0

    申请日：1994-12-16

    申请人： FUJISAWA PHARMACEUTICAL CO., LTD.

    发明人： TANIGUCHI, Kiyoshi ,  NAGANO, Masanobu ,  HATTORI, Kouji ,  TSUBAKI, Kazunori ,  OKITSU, Osamu ,  TABUCHI, Seiichiro

    IPC分类号： A61K31 ,  A61P9 ,  C07D263

    CPC分类号： C07D263/32

    摘要： Heterocyclic compounds of formula (I) wherein R1 is carboxy or protected carboxy, R2 is aryl which may have suitable substituent(s), R3 is aryl which may have suitable substituent(s), A1 is lower alkylene, A2 is bond or lower alkylene and -Q- is (II), etc., and pharmaceutically acceptable salts thereof which are useful as a medicament.

    摘要翻译： 其中R 1为羧基或被保护的羧基的式（I）杂环化合物，R 2为可具有合适取代基的芳基，R 3为可具有合适取代基的芳基，A 1为低级亚烷基，A 2为键或低级亚烷基 和-Q-是（II）等，及其药学上可接受的盐，它们可用作药物。

    ETHANOLAMINE DERIVATIVES WITH ANTI-POLLAKIURIA ACTIVITY
    8.
    发明授权
    ETHANOLAMINE DERIVATIVES WITH ANTI-POLLAKIURIA ACTIVITY 失效
    乙醇胺衍生物麻醉剂防腐剂

    公开(公告)号：EP0579833B1

    公开(公告)日：1997-08-20

    申请号：EP92908496.0

    申请日：1992-04-10

    申请人： FUJISAWA PHARMACEUTICAL CO., LTD.

    发明人： SHIOKAWA, Youichi ,  NAGANO, Masanobu ,  TANIGUCHI, Kiyoshi ,  TAKE Kazuhiko ,  KATO, Takeshi ,  TSUBAKI, Kazunori

    IPC分类号： C07C217/74

    CPC分类号： C07C255/59 ,  C07C217/74 ,  C07C317/32 ,  C07C2602/10

    摘要： This invention relates to new ethanolamine derivatives having gut selective sympathomimetic and anti-pollakiuria activities and represented by general formula (I), wherein R1 is hydrogen or halogen, R2 is halogen, hydroxy, protected hydroxy, aryloxy, lower alkoxy, halo(lower)alkoxy, nitro, cyano, amino or acylamino, R3 is hydrogen or halogen, R4 is hydrogen or lower alkyl, R5 is hydrogen or lower alkyl, R6 is hydrogen, hydroxy or lower alkyl, R7 is hygrogen or lower alkyl, R8 is hydrogen or halogen, R9 is carboxy or esterified carboxy, and A is lower alkylene, provided that R4 is lower alkyl; R5 is lower alkyl; R6 is hydroxy or lower alkyl; or R8 is halogen when R1 is hydrogen, R2 is halogen and R3 is hydrogen, and pharmaceutically acceptable salts thereof, to processes for the preparation thereof and to a pharmaceutical composition comprising the same.

    摘要翻译： 本发明涉及具有肠选择性交感神经和抗血尿功能的新型乙醇胺衍生物，其通式（I）表示，其中R 1为氢或卤素，R 2为卤素，羟基，被保护的羟基，芳氧基，低级 烷氧基，卤代（低级）烷氧基，硝基，氰基，氨基或酰氨基，R 3是氢或卤素，R 4是氢或低级烷基，R 5是氢或低级烷基，R 6是 氢，羟基或低级烷基，R 7为氢或低级烷基，R 8为氢或卤素，R 9为羧基或酯化羧基，A为低级亚烷基，条件是R 4较低 烷基; R 5是低级烷基; R 6是羟基或低级烷基; 或R 8为卤素时，R 1为氢，R 2为卤素且R 3为氢，R 3为其药学上可接受的盐，其制备方法和含有该化合物的药物组合物为卤素。

    ETHANOLAMINE DERIVATIVES HAVING SYMPATHOMIMETIC AND ANTI-POLLAKIURIA ACTIVITIES
    9.
    发明授权
    ETHANOLAMINE DERIVATIVES HAVING SYMPATHOMIMETIC AND ANTI-POLLAKIURIA ACTIVITIES 失效
    乙酰氨基酚衍生物麻疹麻醉药物在抗 - 布列塔尼亚州WIRKUNG

    公开(公告)号：EP0583485B1

    公开(公告)日：1997-08-13

    申请号：EP93914517.3

    申请日：1993-02-01

    申请人： FUJISAWA PHARMACEUTICAL CO., LTD.

    发明人： SHIOKAWA, Youichi ,  NAGANO, Masanobu ,  TANIGUCHI, Kiyoshi ,  TAKE, Kazuhiko ,  KATO, Takeshi ,  TSUBAKI, Kazunori

    IPC分类号： C07C217/74 ,  A61K31/135 ,  C07C215/64 ,  C07C229/46 ,  C07D213/61 ,  C07D317/58 ,  C07D271/12

    CPC分类号： C07C229/16 ,  C07C215/08 ,  C07C215/14 ,  C07C215/64 ,  C07C217/74 ,  C07C235/20 ,  C07C2602/12 ,  C07D213/61 ,  C07D271/12 ,  C07D317/58 ,  Y02P20/55

    摘要： This invention relates to new ethanolamine derivatives having gut selective sympathomimetic and anti-pollakiuria activities and represented by general formula (I) wherein R1 is aryl or a heterocyclic group, each of which may be substituted with halogen, etc., R2 is hydrogen, halogen, nitro, hydroxy, lower alkyl optionally substituted with acyl, lower alkenyl optionally substituted with acyl, lower alkoxy optionally substituted with acyl, or amino optionally substituted with acyl(lower)alkyl, R3 is hydrogen, an N-protective group, or lower alkyl optionally substituted with lower alkylthio, n is an integer of 0 to 3, and a heavy solid line means a single bond or a double bond, provided that when n is 1, then 1) R1 is a condensed aromatic hydrocarbon group or a heterocyclic group, each of which may be substituted with halogen, etc., and the like, and pharmaceutically acceptable salts thereof to processes for the preparation thereof and to a pharmaceutical composition comprising the same.

    摘要翻译： 本发明涉及具有肠选择性交感神经和抗血尿功能的新型乙醇胺衍生物，其通式[I]表示：其中R 1为可被卤素取代的芳基或杂环基， 等等，R2是氢，卤素，硝基，羟基，任选被酰基取代的低级烷基，任选被酰基取代的低级烯基，任选被酰基取代的低级烷氧基或任选被酰基（低级）烷基取代的氨基，R 3是氢， N-保护基或任选被低级烷硫基取代的低级烷基，n为0〜3的整数，重实线表示单键或双键，条件是当n为1时，则R1为 缩合芳族烃基或杂环基，其各自可以被卤素等取代，以及其药学上可接受的盐用于制备方法和药物组合物组合物 上升一样