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    SYSTEM FOR DELIVERY OF PULSED ELECTRIC FIELD ABLATIVE ENERGY TO ENDOCARDIAL TISSUE
    1.
    发明公开
    SYSTEM FOR DELIVERY OF PULSED ELECTRIC FIELD ABLATIVE ENERGY TO ENDOCARDIAL TISSUE 审中-公开

    公开(公告)号：EP4000547A1

    公开(公告)日：2022-05-25

    申请号：EP21193873.3

    申请日：2017-01-04

    申请人： Farapulse, Inc.

    发明人： PAGEARD, Jean-Luc ,  VISWANATHAN, Raju ,  LONG, Gary L.

    IPC分类号： A61B18/14 ,  A61N1/05 ,  A61N1/32 ,  A61N1/362 ,  A61B18/00 ,  A61B18/12 ,  A61B90/00

    摘要： Systems, devices, and methods for electroporation ablation therapy are disclosed, with the system including a pulse waveform signal generator for medical ablation therapy, and an endocardial ablation device includes at least one electrode for ablation pulse delivery to tissue. The signal generator may deliver voltage pulses to the ablation device in the form of a pulse waveform. The system may include a cardiac stimulator for generation of pacing signals and for sequenced delivery of pulse waveforms in synchrony with the pacing signal. The pulse waveform including:
    • a first level of a hierarchy of the pulse waveform includes a first set of pulses, each pulse having a pulse time duration, a first time interval separating successive pulses;
    • a second level of the hierarchy of the pulse waveform includes a plurality of first sets of pulses as a second set of pulses, a second time interval separating successive first sets of pulses, the second time interval being at least three times the duration of the first time interval; and
    • a third level of the hierarchy of the pulse waveform includes a plurality of second sets of pulses as a third set of pulses, a third time interval separating successive second sets of pulses, the third time interval being at least thirty times the duration of the second level time interval

    SYSTEMS, DEVICES, AND METHODS FOR DELIVERY OF PULSED ELECTRIC FIELD ABLATIVE ENERGY TO ESOPHAGEAL TISSUE
    3.
    发明公开
    SYSTEMS, DEVICES, AND METHODS FOR DELIVERY OF PULSED ELECTRIC FIELD ABLATIVE ENERGY TO ESOPHAGEAL TISSUE 审中-公开

    公开(公告)号：EP3456278A3

    公开(公告)日：2019-06-19

    申请号：EP18170210.1

    申请日：2018-04-30

    申请人： Farapulse, Inc.

    发明人： PAGEARD, Jean-Luc ,  LONG, Gary L. ,  VISWANATHAN, Raju

    IPC分类号： A61B18/00 ,  A61N1/05 ,  A61N1/32

    摘要： Systems, devices, and methods for electroporation ablation therapy are disclosed in the context of esophageal ablation. An ablation device may include a first catheter defining a longitudinal axis and a lumen therethrough. A balloon may be coupled to the first catheter. The balloon may be configured to transition between a deflated configuration and an inflated configuration. A second catheter may extend from a distal end of the first catheter lumen. A set of splines including electrodes formed on a surface of each of the splines may couple to the distal end of the first catheter lumen and a distal portion of the second catheter. The second catheter may be configured for translation along the longitudinal axis to transition the set of splines between a first configuration and a second configuration.

    SYSTEMS, DEVICES, AND METHODS FOR SIGNAL GENERATION
    10.
    发明公开
    SYSTEMS, DEVICES, AND METHODS FOR SIGNAL GENERATION 审中-公开

    公开(公告)号：EP4186454A1

    公开(公告)日：2023-05-31

    申请号：EP23151422.5

    申请日：2018-04-26

    申请人： Farapulse, Inc.

    发明人： BOWERS, William ,  VISWANATHAN, Raju ,  LONG, Gary

    IPC分类号： A61B18/14 ,  A61B18/12 ,  A61B18/00 ,  A61N1/05 ,  A61N1/362 ,  A61N1/32

    摘要： Systems, devices, and methods for electroporation ablation therapy are disclosed, with the system including a pulse waveform signal generator for medical ablation therapy that may be coupled to an ablation device including at least one electrode for ablation pulse delivery to tissue. The signal generator may generate and deliver voltage pulses to the ablation device in the form of a pulse waveform in a predetermined sequence where the signal generator may independently configure a set of electrodes of an ablation device. The signal generator may further perform active monitoring of a set of electrode channels and discharge excess energy using the set of electrode channels.