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    RECOMBINANT FSH INCLUDING ALPHA 2,3- AND ALPHA 2,6-SIALYLATION
    3.
    发明公开
    RECOMBINANT FSH INCLUDING ALPHA 2,3- AND ALPHA 2,6-SIALYLATION 审中-公开
    重组FSH包括α2,3-和α2,6-二酰化

    公开(公告)号：EP3098234A1

    公开(公告)日：2016-11-30

    申请号：EP16179121.5

    申请日：2009-04-16

    申请人： Ferring B.V.

    发明人： COTTINGHAM, Ian ,  PLAKSIN, Daniel ,  WHITE, Richard, Boyd

    IPC分类号： C07K14/59 ,  A61K38/24 ,  A61K38/00

    CPC分类号： C07K14/59 ,  A61K38/00

    摘要： Preparations including recombinant FSH (rFSH).
    Figs 1, 2 and 3: Plasmid maps of the pFSHalpha/beta, pST3 and pST6 expression vectors. CMV = Cytomegalovirus promoter, BGHp(A) = Bovine Growth Hormone poly-adenylation sequence, fl ori = fl origin of replication, SV40 = Simian Virus 40 promoter, Neo = neomycin resistance marker, Hyg = Hygromycin resistance marker, SV40 p(A) = Simian Virus 40 poly-adenylation sequence, FSH A = Follicle stimulating hormone alpha polypeptide, FSH B) Follicle stimulating hormone beta polypeptide, ST3GAL4 = α2,6-sialyltransferase, ColEl = ColEl origine of replication, Amp = ampicillin resistance marker.

    摘要翻译： 包括重组FSH（rFSH）在内的制剂。 图1,2和3：pFSHα/β，pST3和pST6表达载体的质粒图谱。 CMV =巨细胞病毒启动子，BGHp（A）=牛生长激素聚腺苷酸化序列，fl ori = fl复制起点，SV40 =猿猴病毒40启动子，Neo =新霉素抗性标记，Hyg =潮霉素抗性标记，SV40p =猿猴病毒40聚腺苷酸化序列，FSH A =促卵泡激素α多肽，FSH B）促卵泡激素β多肽，ST3GAL4 =α2,6-唾液酸转移酶，ColE1 = ColE1复制起点，Amp =氨苄青霉素抗性标记物。

    ADMINISTRATION OF A SELECTIVE IL-6-TRANS-SIGNALLING INHIBITOR
    7.
    发明公开
    ADMINISTRATION OF A SELECTIVE IL-6-TRANS-SIGNALLING INHIBITOR 审中-公开
    选择性IL-6转导信号抑制剂的施用

    公开(公告)号：EP3226888A1

    公开(公告)日：2017-10-11

    申请号：EP15832692.6

    申请日：2015-12-01

    申请人： Ferring B.V.

    发明人： COTTINGHAM, Ian ,  PETRI, Niclas, Axel

    IPC分类号： A61K38/20 ,  C07K14/715

    CPC分类号： C07K14/7155 ,  A61K38/00 ,  C07K14/5412 ,  C07K2319/30

    摘要： A selective IL-6-trans-signalling inhibitor can be used to treat a variety of IL-6-mediated conditions, including inflammatory diseases and cancer. The inhibitor can safely be administered to humans at a variety of doses. Moreover, the inhibitor lessens deleterious effects associated with other IL-6 inhibitors such as lowering neutrophil counts, platelet counts and levels of C-reactive protein.

    摘要翻译： 选择性IL-6反式信号抑制剂可用于治疗多种IL-6介导的病症，包括炎性疾病和癌症。 该抑制剂可以安全地以各种剂量施用给人。 此外，该抑制剂减轻了与其他IL-6抑制剂相关的有害作用，例如降低嗜中性粒细胞计数，血小板计数和C-反应蛋白水平。

    PHARMACEUTICAL PREPARATION COMPRISING RECOMBINANT HCG
    10.
    发明公开
    PHARMACEUTICAL PREPARATION COMPRISING RECOMBINANT HCG 审中-公开
    药剂ZUBEREITUNG MIT REKOMBINANTEM HCG

    公开(公告)号：EP2486051A1

    公开(公告)日：2012-08-15

    申请号：EP10763000.6

    申请日：2010-10-04

    申请人： Ferring B.V.

    发明人： COTTINGHAM, Ian ,  PLAKSIN, Daniel ,  WHITE, Richard, Boyd

    IPC分类号： C07K14/59 ,  A61K38/24

    摘要： The present disclosure describes recombinant human chorionic gonadotropin (hCG) and methods for the production thereof. The recombinant hCG can include α2,3, α2,6, and, optionally, α2,8 sialylation. The recombinant hCG can be produced in a human cell line such as a PER.C6® cell line.

    摘要翻译： 本公开描述了重组人绒毛膜促性腺激素（hCG）及其生产方法。 重组hCG可以包括α2,3，α2,6和任选的α2,8唾液酸化。 重组hCG可以在人细胞系如PER.C6细胞系中产生。