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公开(公告)号：EP1487472A2
公开(公告)日：2004-12-22
申请号：EP02797195.1
申请日：2002-12-06
申请人： FIBROGEN, INC.
发明人： GUENZLER-PUKALL, Volkmar , NEFF, Thomas, B. , WANG, Qingjian , AREND, Michael P. , FLIPPIN, Lee, A.
CPC分类号： A61K31/4745 , A61K31/00 , A61K31/17 , A61K31/4375 , A61K31/44 , A61K31/4418 , A61K31/47 , A61K31/472 , A61K31/4738 , A61K31/496 , A61K31/63 , A61K38/1709 , C07K14/4702 , C07K14/505 , G01N33/746
摘要： The present invention relates to methods of stabilizing the alpha subunit of hypoxia inducible factor (HIF). The invention further relates to methods of preventing, pretreating, or treating conditions associated with HIF, including ischemic and hypoxic conditions. Compounds for use in these methods are also provided.
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公开(公告)号：EP2298301A2
公开(公告)日：2011-03-23
申请号：EP10181796.3
申请日：2002-12-06
申请人： Fibrogen, Inc.
发明人： KLAUS, Stephen J. , LIN, Al Y. , NEFF, Thomas B. , WANG, Qingjian , GUENZLER-PUKALL, Volkmar , AREND, Michael P. , FLIPPIN, Lee A.
IPC分类号： A61K31/47 , A61K31/4738 , A61K31/63 , A61K38/17 , A61K31/00 , C07K14/47 , C07K14/505 , A61P7/06
CPC分类号： A61K31/4745 , A61K31/00 , A61K31/17 , A61K31/4375 , A61K31/44 , A61K31/4418 , A61K31/47 , A61K31/472 , A61K31/4738 , A61K31/496 , A61K31/63 , A61K38/1709 , C07K14/4702 , C07K14/505 , G01N33/746
摘要： The present invention relates to compounds for use in methods for treating erythropoietin-associated conditions by increasing endogenous erythropoietin in vitro and in vivo . Compounds for use in methods for treating, pretreating or preconditioning, or preventing erythropoietin-associated conditions are also included.
摘要翻译： 本发明涉及用于通过在体外和体内增加内源促红细胞生成素来治疗促红细胞生成素相关病症的方法中使用的化合物。 还包括用于治疗，预处理或预处理或预防促红细胞生成素相关病症的方法的化合物。
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公开(公告)号：EP1487472B1
公开(公告)日：2019-06-26
申请号：EP02797195.1
申请日：2002-12-06
申请人： Fibrogen, Inc.
发明人： GUENZLER-PUKALL, Volkmar , NEFF, Thomas, B. , WANG, Qingjian , AREND, Michael P. , FLIPPIN, Lee, A.
IPC分类号： A61K31/44 , A61K31/4418 , A61K31/472 , A61K31/47 , A61K31/4738 , A61K31/496 , A61K31/4375 , A61K31/17 , C12N15/09 , C12Q1/56 , C12Q1/34 , A61K38/17 , A61K31/63 , A61K31/4745 , C07K14/505 , C07K14/47 , A61K38/00 , A61P9/10 , A61P1/16 , A61P11/00
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4.发明授权CTGF AS TARGET FOR THE THERAPY OF MICROALBUMINURIA IN PATIENTS WITH DIABETIC NEPHROPATHY 有权CTGF AS靶分子中微量白蛋白尿的患者治疗糖尿病肾病
公开(公告)号：EP1715890B1
公开(公告)日：2008-07-09
申请号：EP05713358.9
申请日：2005-02-11
申请人： FIBROGEN, INC.
发明人： FLYVBJERG, Allan , GUO, Guangjie , LIU, David, Y. , NEFF, Thomas, B. , OLIVER, Noelynn, A. , USINGER, William, R. , WANG, Qingjian
IPC分类号： A61K39/39 , A61K39/395 , A61K31/00 , A61K38/00 , A61P13/12
CPC分类号： A61K38/556 , A61K31/00 , A61K39/395 , A61K2039/505 , C07K16/22 , A61K2300/00
摘要： The present invention relates to methods and compounds for treating specific early stage aspects and late stage aspects of diabetic nephropathy. Methods and compounds for treating various physiological features associated with early stage and with late stage diabetic nephropathy are also provided.
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公开(公告)号：EP1463823A2
公开(公告)日：2004-10-06
申请号：EP02805548.1
申请日：2002-12-06
申请人： FibroGen, Inc.
发明人： KLAUS, Stephen, J. , LIN, Al, Y. , NEFF, Thomas, B. , WANG, Qingjian , GUENZLER-PUKALL, Volkmar , AREND, Michael, P. , FLIPPIN, Lee, A.
CPC分类号： A61K31/4745 , A61K31/00 , A61K31/17 , A61K31/4375 , A61K31/44 , A61K31/4418 , A61K31/47 , A61K31/472 , A61K31/4738 , A61K31/496 , A61K31/63 , A61K38/1709 , C07K14/4702 , C07K14/505 , G01N33/746
摘要： The present invention relates to methods of stabilizing the alpha subunit of hypoxia inducible factor (HIF). The invention further relates to methods of preventing, pretreating, or treating conditions associated with HIF, including ischemic and hypoxic conditions. Compounds for use in these methods are also provided.
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公开(公告)号：EP2298301B1
公开(公告)日：2018-07-04
申请号：EP10181796.3
申请日：2002-12-06
申请人： Fibrogen, Inc.
发明人： KLAUS, Stephen J. , LIN, Al Y. , NEFF, Thomas B. , WANG, Qingjian , GUENZLER-PUKALL, Volkmar , AREND, Michael P. , FLIPPIN, Lee A.
IPC分类号： A61K31/47 , A61K31/4738 , A61K31/63 , A61K38/17 , A61K31/00 , C07K14/47 , C07K14/505 , A61P7/06 , G01N33/74 , C12N15/09 , C12Q1/34 , C12Q1/56 , A61K31/472 , A61K31/4745 , A61K31/17 , A61K31/4375 , A61K31/44 , A61K31/4418 , A61K31/496
CPC分类号： A61K31/4745 , A61K31/00 , A61K31/17 , A61K31/4375 , A61K31/44 , A61K31/4418 , A61K31/47 , A61K31/472 , A61K31/4738 , A61K31/496 , A61K31/63 , A61K38/1709 , C07K14/4702 , C07K14/505 , G01N33/746
摘要： The present invention relates to methods of stabilizing the alpha subunit of hypoxia inducible factor (HIF). The invention further relates to methods of preventing, pretreating, or treating conditions associated with HIF, including ischemic and hypoxic conditions. Compounds for use in these methods are also provided.
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公开(公告)号：EP2298301A3
公开(公告)日：2013-03-13
申请号：EP10181796.3
申请日：2002-12-06
申请人： Fibrogen, Inc.
发明人： KLAUS, Stephen J. , LIN, Al Y. , NEFF, Thomas B. , WANG, Qingjian , GUENZLER-PUKALL, Volkmar , AREND, Michael P. , FLIPPIN, Lee A.
IPC分类号： A61K31/47 , A61K31/4738 , A61K31/63 , A61K38/17 , A61K31/00 , C07K14/47 , C07K14/505 , A61P7/06 , G01N33/74 , C12N15/09 , C12Q1/34 , C12Q1/56
CPC分类号： A61K31/4745 , A61K31/00 , A61K31/17 , A61K31/4375 , A61K31/44 , A61K31/4418 , A61K31/47 , A61K31/472 , A61K31/4738 , A61K31/496 , A61K31/63 , A61K38/1709 , C07K14/4702 , C07K14/505 , G01N33/746
摘要： The present invention relates to compounds for use in methods for treating erythropoietin-associated conditions by increasing endogenous erythropoietin in vitro and in vivo . Compounds for use in methods for treating, pretreating or preconditioning, or preventing erythropoietin-associated conditions are also included.
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公开(公告)号：EP1715890A1
公开(公告)日：2006-11-02
申请号：EP05713358.9
申请日：2005-02-11
申请人： FIBROGEN, INC.
发明人： FLYVBJERG, Allan , GUO, Guangjie , LIU, David, Y. , NEFF, Thomas, B. , OLIVER, Noelynn, A. , USINGER, William, R. , WANG, Qingjian
IPC分类号： A61K39/39 , A61K39/395 , A61K31/00 , A61K38/00 , A61P13/12
CPC分类号： A61K38/556 , A61K31/00 , A61K39/395 , A61K2039/505 , C07K16/22 , A61K2300/00
摘要： The present invention relates to methods and compounds for treating specific early stage aspects and late stage aspects of diabetic nephropathy. Methods and compounds for treating various physiological features associated with early stage and with late stage diabetic nephropathy are also provided.
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公开(公告)号：EP1631591A2
公开(公告)日：2006-03-08
申请号：EP04753822.8
申请日：2004-06-02
申请人： FIBROGEN, INC.
发明人： LIN, Ai, Y. , NEFF, Thomas, B. , OLIVER, Noelynn, A. , USINGER, William, R. , WANG, Qingjian , YEOWELL, David, A.
IPC分类号： C07K16/22
CPC分类号： C07K16/22 , A61K2039/505 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/35 , C07K2317/41 , C07K2317/54 , C07K2317/55 , C07K2317/622 , C07K2317/76 , C07K2317/92
摘要： The present invention relates to antibodies that bind to CTGF. The antibodies are particularly directed to regions of CTGF involved in biological activities associated with fibrosis. The invention also relates to methods of using the antibodies to treat disorders associated with CTGF including localized and systemic fibrotic disorders including those of the lung, liver, heart, skin, and kidney.
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公开(公告)号：EP3520784A1
公开(公告)日：2019-08-07
申请号：EP19172616.5
申请日：2002-12-06
申请人： Fibrogen, Inc.
发明人： KLAUS, Stephen J. , LIN, Al Y. , NEFF, Thomas B. , WANG, Qingjian , GUENZLER-PUKALL, Volkmar , AREND, Michael P. , FLIPPIN, Lee A.
IPC分类号： A61K31/17 , A61K31/4375 , A61K31/44 , A61K31/4418 , A61K31/47 , A61K31/472 , A61K31/4738 , A61K31/4745 , A61K31/496 , A61K31/63 , C07K14/505 , A61K31/00 , C07K14/47 , G01N33/74 , A61K38/17
摘要： The present invention relates to methods for treating anemia by increasing endogenous erythropoietin via inhibition of HIF prolyl hydroxylase enzyme activity.
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