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公开(公告)号：EP1463531B1
公开(公告)日：2011-09-28
申请号：EP02804786.8
申请日：2002-12-11
IPC分类号： A61K48/00 , A61K39/395 , G01N33/53 , A61P27/02
CPC分类号： G01N33/6887 , A61K48/00 , A61K2039/505 , A61K2039/54 , C07K14/475 , C07K16/22 , C12N2799/022 , G01N2333/475
摘要： The present invention relates to methods for inhibiting or preventing ocular processes associated with CTGF. Methods and agents for use in treating or preventing ocular disorders, methods for diagnosing ocular disorders and related kits, and methods for screening for agents for use in the present methods are also provided.
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公开(公告)号：EP1463531A1
公开(公告)日：2004-10-06
申请号：EP02804786.8
申请日：2002-12-11
IPC分类号： A61K48/00 , A61K39/395 , G01N33/53
CPC分类号： G01N33/6887 , A61K48/00 , A61K2039/505 , A61K2039/54 , C07K14/475 , C07K16/22 , C12N2799/022 , G01N2333/475
摘要： The present invention relates to methods for inhibiting or preventing ocular processes associated with CTGF. Methods and agents for use in treating or preventing ocular disorders, methods for diagnosing ocular disorders and related kits, and methods for screening for agents for use in the present methods are also provided.
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3.发明授权CTGF AS TARGET FOR THE THERAPY OF MICROALBUMINURIA IN PATIENTS WITH DIABETIC NEPHROPATHY 有权CTGF AS靶分子中微量白蛋白尿的患者治疗糖尿病肾病
公开(公告)号：EP1715890B1
公开(公告)日：2008-07-09
申请号：EP05713358.9
申请日：2005-02-11
申请人： FIBROGEN, INC.
发明人： FLYVBJERG, Allan , GUO, Guangjie , LIU, David, Y. , NEFF, Thomas, B. , OLIVER, Noelynn, A. , USINGER, William, R. , WANG, Qingjian
IPC分类号： A61K39/39 , A61K39/395 , A61K31/00 , A61K38/00 , A61P13/12
CPC分类号： A61K38/556 , A61K31/00 , A61K39/395 , A61K2039/505 , C07K16/22 , A61K2300/00
摘要： The present invention relates to methods and compounds for treating specific early stage aspects and late stage aspects of diabetic nephropathy. Methods and compounds for treating various physiological features associated with early stage and with late stage diabetic nephropathy are also provided.
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公开(公告)号：EP1631591B1
公开(公告)日：2011-12-21
申请号：EP04753822.8
申请日：2004-06-02
申请人： FIBROGEN, INC.
发明人： LIN, Ai, Y. , NEFF, Thomas, B. , OLIVER, Noelynn, A. , USINGER, William, R. , WANG, Qingjian , YEOWELL, David, A.
IPC分类号： C07K16/22
CPC分类号： C07K16/22 , A61K2039/505 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/35 , C07K2317/41 , C07K2317/54 , C07K2317/55 , C07K2317/622 , C07K2317/76 , C07K2317/92
摘要： The present invention relates to antibodies that bind to CTGF. The antibodies are particularly directed to regions of CTGF involved in biological activities associated with fibrosis. The invention also relates to methods of using the antibodies to treat disorders associated with CTGF including localized and systemic fibrotic disorders including those of the lung, liver, heart, skin, and kidney.
摘要翻译： 本发明涉及结合CTGF的抗体。 抗体特别针对参与与纤维化相关的生物活性的CTGF的区域。 本发明还涉及使用抗体治疗与CTGF相关的疾病的方法，包括局部和全身纤维化疾病，包括肺，肝脏，心脏，皮肤和肾脏的疾病。
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公开(公告)号：EP1715890A1
公开(公告)日：2006-11-02
申请号：EP05713358.9
申请日：2005-02-11
申请人： FIBROGEN, INC.
发明人： FLYVBJERG, Allan , GUO, Guangjie , LIU, David, Y. , NEFF, Thomas, B. , OLIVER, Noelynn, A. , USINGER, William, R. , WANG, Qingjian
IPC分类号： A61K39/39 , A61K39/395 , A61K31/00 , A61K38/00 , A61P13/12
CPC分类号： A61K38/556 , A61K31/00 , A61K39/395 , A61K2039/505 , C07K16/22 , A61K2300/00
摘要： The present invention relates to methods and compounds for treating specific early stage aspects and late stage aspects of diabetic nephropathy. Methods and compounds for treating various physiological features associated with early stage and with late stage diabetic nephropathy are also provided.
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公开(公告)号：EP1631591A2
公开(公告)日：2006-03-08
申请号：EP04753822.8
申请日：2004-06-02
申请人： FIBROGEN, INC.
发明人： LIN, Ai, Y. , NEFF, Thomas, B. , OLIVER, Noelynn, A. , USINGER, William, R. , WANG, Qingjian , YEOWELL, David, A.
IPC分类号： C07K16/22
CPC分类号： C07K16/22 , A61K2039/505 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/35 , C07K2317/41 , C07K2317/54 , C07K2317/55 , C07K2317/622 , C07K2317/76 , C07K2317/92
摘要： The present invention relates to antibodies that bind to CTGF. The antibodies are particularly directed to regions of CTGF involved in biological activities associated with fibrosis. The invention also relates to methods of using the antibodies to treat disorders associated with CTGF including localized and systemic fibrotic disorders including those of the lung, liver, heart, skin, and kidney.
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