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    IMPROVED DISPOSABLE BIOREACTOR VESSEL PORT
    1.
    发明授权
    IMPROVED DISPOSABLE BIOREACTOR VESSEL PORT 有权

    公开(公告)号：EP2046941B1

    公开(公告)日：2017-08-23

    申请号：EP07795356.0

    申请日：2007-05-25

    申请人： Finesse Solutions, Inc.

    发明人： SELKER, Mark ,  JOHNSTON, Timothy ,  PALDUS, Barbara

    IPC分类号： C12M1/36

    CPC分类号： C12M23/00

    摘要： A port for use with a bioreactor vessel comprising: i) a base member comprising a hollow tubular portion and a base plate configured to be sealingly affixed to a hole in the wall of a bioreactor vessel ii) a hollow, generally tubular bushing member for containing electrical, optical, microfluidic and/or chemical monitoring components which bushing member fits inside the bore of the tubular portion of the base member, both the base member and bushing member providing access to the contents of a bioreactor by; iii) a monitoring assembly inserted into the bushing member which assembly comprises means for providing incoming optical and/or electrical signals and means for collecting and transmitting measurement signals resulting from the interaction of incoming optical and/or electrical signals with the contents of a bioreactor; and iv) a cover which maintains the position and alignment of components ii) and iii) relative to the base member.

    IMPROVED DISPOSABLE BIOREACTOR VESSEL PORT
    2.
    发明公开
    IMPROVED DISPOSABLE BIOREACTOR VESSEL PORT 审中-公开
    改进的一次性生物反应器容器端口

    公开(公告)号：EP3246393A1

    公开(公告)日：2017-11-22

    申请号：EP17180340.6

    申请日：2007-05-25

    申请人： Finesse Solutions, Inc.

    发明人： SELKER, Mark ,  JOHNSTON, Timothy ,  PALDUS, Barbara

    IPC分类号： C12M1/36

    CPC分类号： C12M23/00

    摘要： A port for use with a bioreactor vessel comprising:
    i) a base member comprising a hollow tubular portion and a base plate configured to be sealingly affixed to a hole in the wall of a bioreactor vessel
    ii) a hollow, generally tubular bushing member for containing electrical, optical, microfluidic and/or chemical monitoring components which bushing member fits inside the bore of the tubular portion of the base member, both the base member and bushing member providing access to the contents of a bioreactor by;
    iii) a monitoring assembly inserted into the bushing member which assembly comprises means for providing incoming optical and/or electrical signals and means for collecting and transmitting measurement signals resulting from the interaction of incoming optical and/or electrical signals with the contents of a bioreactor; and
    iv) a cover which maintains the position and alignment of components ii) and iii) relative to the base member.

    摘要翻译： 一种与生物反应器容器一起使用的端口，包括：i）基部构件，该基部构件包括中空管状部分和构造成密封地固定到生物反应器容器的壁中的孔的基板，ii）中空的，大致管状的衬套构件， 电气，光学，微流体和/或化学监测部件，所述衬套构件装配在所述基部构件的所述管状部分的孔内，所述基部构件和所述衬套构件均提供通向生物反应器的内容物的通路; iii）插入套管构件中的监测组件，所述组件包括用于提供输入光信号和/或电信号的装置以及用于收集和传输由输入光信号和/或电信号与生物反应器内容物相互作用产生的测量信号的装置; 和iv）保持部件ii）和iii）相对于基座部件的位置和对齐的盖子。

    BIOREACTOR WITH MULTIPLE COUPLED VESSELS
    5.
    发明公开
    BIOREACTOR WITH MULTIPLE COUPLED VESSELS 审中-公开
    具有多个耦合容器的生物反应器

    公开(公告)号：EP3290507A1

    公开(公告)日：2018-03-07

    申请号：EP17188616.1

    申请日：2017-08-30

    申请人： Finesse Solutions, Inc.

    发明人： PALDUS, Barbara ,  SELKER, Mark D.

    IPC分类号： C12M1/00 ,  C12M3/00 ,  C12M1/06 ,  C12M3/06 ,  C12M1/34

    CPC分类号： C12M23/02 ,  C12M23/40 ,  C12M23/44 ,  C12M23/58 ,  C12M25/06 ,  C12M27/00 ,  C12M27/02 ,  C12M27/16 ,  C12M29/10 ,  C12M29/16 ,  C12M29/18 ,  C12M33/14 ,  C12M41/12 ,  C12M41/26 ,  C12M41/44

    摘要： A bioreactor system may include (a) two or more fluidically coupled vessels configured to collectively carry out a bioreaction; (b) one or more fluidic paths coupling the two or more vessels to one another, where the fluidic paths are configured to provide flow of culture medium between the two or more vessels; (c) one or more fluid transfer devices along at least some of the one or more fluidic paths; and (d) a control system. The control system may be configured to (i) read or receive values of one or more parameters characterizing the culture medium in one or more of the vessels, and (ii) use the values to determine an adjusted flow rate in at least one of the fluidic paths to maintain substantially uniform values of the one or more parameters in the culture medium from vessel-to-vessel among the two or more vessels.

    摘要翻译： 生物反应器系统可以包括（a）被配置为共同执行生物反应的两个或更多个流体耦合容器; （b）将所述两个或更多个容器彼此连接的一个或更多个流体路径，其中所述流体路径被配置成提供所述两个或更多个容器之间的培养基的流动; （c）沿着所述一个或多个流体路径中的至少一些流体路径的一个或多个流体传输装置; 和（d）一个控制系统。 控制系统可以被配置为（i）读取或接收表征一个或多个容器中的培养基的一个或多个参数的值，并且（ii）使用这些值来确定在至少一个 流体路径以在两个或更多个容器之间的血管对血管中保持培养基中的一个或多个参数的基本上均匀的值。