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公开(公告)号：EP2287310B1
公开(公告)日：2015-05-06
申请号：EP10179665.4
申请日：2005-07-21
发明人： Behrens, Dirk , Bosch, Elizabeth , Doberstein, Steven , Halenbeck, Robert, Forgan , Hestir, Kevin , Huang, Min, Mei , Lee, Ernestine , Lin, Haishan , Linnemann, Thomas , Marshall, Shannon , Wong, Justin, G., P. , WU, Ge , Zhou, Aileen , Leo, Cindy , Williams, Lewis, T.
CPC分类号： C07K16/243 , A61K38/00 , C07K14/53
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公开(公告)号：EP2479277B1
公开(公告)日：2015-09-02
申请号：EP12150386.6
申请日：2005-07-21
发明人： Behrens, Dirk , Marshall, Shannon , Wong, Justin, G., P. , Wu, Ge , Zhou, Aileen , Leo, Cindy , Williams, Lewis, T. , Bosch, Elizabeth , Doberstein, Steven , Halenbeck, Robert, Forgan , Hestir, Kevin , Huang, Min, Mei , Lee, Ernestine , Lin, Haishan , Linnemann, Thomas
CPC分类号： C07K16/243 , A61K38/00 , C07K14/53
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公开(公告)号：EP2479277A3
公开(公告)日：2012-08-22
申请号：EP12150386.6
申请日：2005-07-21
发明人： Behrens, Dirk , Marshall, Shannon , Wong, Justin, G., P. , Wu, Ge , Zhou, Aileen , Leo, Cindy , Williams, Lewis, T. , Bosch, Elizabeth , Doberstein, Steven , Halenbeck, Robert, Forgan , Hestir, Kevin , Huang, Min, Mei , Lee, Ernestine , Lin, Haishan , Linnemann, Thomas
CPC分类号： C07K16/243 , A61K38/00 , C07K14/53
摘要： The present invention relates to in vitro methods for stimulating, or increasing a population of, immune cells comprising using compositions which comprise a substantially pure polypeptide comprising a first amino acid sequence having at least about 70% homology to a sequence selected from SEQ. ID. NOs:7, 8, 9, and 11; or a biologically active fragment of any of these, wherein said polypeptide or fragment thereof can stimulate the proliferation and differentiation of granulocytes, monocytes, or dendritic cells; and to the use of these polypeptides in methods of treatment
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4.发明公开Compositions and methods of treating disease with FGFR fusion proteins 审中-公开Zusammensetzungen und Verfahren zur Behandlung von Krankheiten mit FGFR-Fusionsproteinen
公开(公告)号：EP2083081A1
公开(公告)日：2009-07-29
申请号：EP09075061.3
申请日：2006-07-24
发明人： Williams, Lewis T. , Bosch, Elizabeth , Doberstein, Stephen , Hestir, Kevin , Hollenbaugh, Diane , Lee, Ernestine , Qin, Minmin , Sadra, Ali , Wong, Justin , Wu, Ge , Zhang, Hongbing
CPC分类号： C07K14/71 , A61K45/06 , C07K14/765 , C07K16/2863 , C07K17/08 , C07K2319/30 , C07K2319/32
摘要： The invention provides FGFR fusion proteins, methods of making them, and methods of using them to treat proliferative disorders, including cancers and disorders of angiogenesis. The FGFR fusion molecules can be made in CHO cells and may comprise deletion mutations in the extracellular domains of the FGFRs which improve their stability. These fusion proteins inhibit the growth and viability of cancer cells in vitro and in vivo. The combination of the relatively high affinity of these receptors for their ligand FGFs and the demonstrated ability of these decoy receptors to inhibit tumor growth is an indication of the clinical value of the compositions and methods provided herein.
摘要翻译： 本发明提供了FGFR融合蛋白，其制备方法以及使用它们来治疗增殖性疾病（包括癌症和血管生成障碍）的方法。 FGFR融合分子可以在CHO细胞中制备，并且可以包含改善其稳定性的FGFRs的细胞外结构域中的缺失突变。 这些融合蛋白在体外和体内抑制癌细胞的生长和活力。 这些受体对其配体FGF的相对高亲和力的组合以及这些诱饵受体抑制肿瘤生长的证明的能力是本文提供的组合物和方法的临床价值的指示。
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5.发明公开Compositions and methods of use for MGD-CSF in disease treatment 有权Verwendung von MGD-CDF zur Behandlung der Alzheimer's Krankheit
公开(公告)号：EP2479277A2
公开(公告)日：2012-07-25
申请号：EP12150386.6
申请日：2005-07-21
发明人： Behrens, Dirk , Marshall, Shannon , Wong, Justin, G., P. , Wu, Ge , Zhou, Aileen , Leo, Cindy , Williams, Lewis, T. , Bosch, Elizabeth , Doberstein, Steven , Halenbeck, Robert, Forgan , Hestir, Kevin , Huang, Min, Mei , Lee, Ernestine , Lin, Haishan , Linnemann, Thomas
CPC分类号： C07K16/243 , A61K38/00 , C07K14/53
摘要： The present invention relates to in vitro methods for stimulating, or increasing a population of, immune cells comprising using compositions which comprise a substantially pure polypeptide comprising a first amino acid sequence having at least about 70% homology to a sequence selected from SEQ. ID. NOs:7, 8, 9, and 11; or a biologically active fragment of any of these, wherein said polypeptide or fragment thereof can stimulate the proliferation and differentiation of granulocytes, monocytes, or dendritic cells; and to the use of these polypeptides in methods of treatment
摘要翻译： 本发明涉及用于刺激或增加免疫细胞群体的体外方法，其包括使用包含基本上纯的多肽的组合物，所述组合物包含与选自SEQ ID NO：1的序列具有至少约70％同源性的第一氨基酸序列。 ID。 NO：7,8,9和11; 或任何这些的生物活性片段，其中所述多肽或其片段可以刺激粒细胞，单核细胞或树突状细胞的增殖和分化; 以及这些多肽在治疗方法中的用途
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6.发明公开Compositions and methods of use for mgd-csf in disease treatment 有权Zusammensetzungen und Verfahren zur Verwendung von MGD-CSF zur Krankheitsbehandlung
公开(公告)号：EP2287310A1
公开(公告)日：2011-02-23
申请号：EP10179665.4
申请日：2005-07-21
发明人： Behrens, Dirk , Bosch, Elizabeth , Doberstein, Steven , Halenbeck, Robert, Forgan , Hestir, Kevin , Huang, Min, Mei , Lee, Ernestine , Lin, Haishan , Linnemann, Thomas , Marshall, Shannon , Wong, Justin, G., P. , WU, Ge , Zhou, Aileen , Leo, Cindy , Williams, Lewis, T.
CPC分类号： C07K16/243 , A61K38/00 , C07K14/53
摘要： The present invention relates to in vitro methods for stimulating, or increasing a population of, immune cells comprising using compositions which comprise a substantially pure polypeptide comprising a first amino acid sequence having at least about 70% homology to a sequence selected from SEQ. ID. NOs:7, 8, 9, and 11; or a biologically active fragment of any of these, wherein said polypeptide or fragment thereof can stimulate the proliferation and differentiation of granulocytes, monocytes, or dendritic cells; and to the use of these polypeptides in methods of treatment
摘要翻译： 本发明涉及用于刺激或增加免疫细胞群体的体外方法，其包括使用包含基本上纯的多肽的组合物，所述组合物包含与选自SEQ ID NO：1的序列具有至少约70％同源性的第一氨基酸序列。 ID。 NO：7,8,9和11; 或任何这些的生物活性片段，其中所述多肽或其片段可以刺激粒细胞，单核细胞或树突状细胞的增殖和分化; 以及这些多肽在治疗方法中的用途
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