公开(公告)号：EP4041760A1

公开(公告)日：2022-08-17

申请号：EP20874677.6

申请日：2020-10-08

申请人： Zymeworks Inc. ,  Provincial Health Services Authority ,  UVic Industry Partnerships Inc.

发明人： VOLKERS, Gesa ,  FULLER, Megan ,  BOULANGER, Martin J. ,  DIXIT, Surjit Bhimarao ,  NELSON, Brad ,  SANCHES, Mario ,  LOVELESS, Bianca

IPC分类号： C07K14/715 ,  A61K35/12 ,  A61K35/17 ,  A61P29/00 ,  A61P31/00 ,  A61P35/00 ,  A61P37/06 ,  C07K14/705 ,  C07K19/00 ,  C12N1/21 ,  C12N15/12 ,  C12N15/27 ,  C12N15/62 ,  C12N15/63 ,  C12N15/85 ,  C12N5/078 ,  C12N5/10 ,  C12P21/02

公开(公告)号：EP3460044A1

公开(公告)日：2019-03-27

申请号：EP18187407.4

申请日：2015-05-16

申请人： Academia Sinica

发明人： CHANG, Jui-Jen ,  THIA, Caroline ,  LIN, Hao-Yeh ,  LIN, Yu-Ju ,  HUANG, Chieh-Chen ,  LI, Wen-Hsiung

IPC分类号： C12N1/13 ,  C12N15/27 ,  C12N15/52 ,  C12N15/82 ,  C12N15/21 ,  C12N15/16

摘要： Disclosed herein are recombinant polynucleotide sequences, vectors, host cells and methods for producing astaxanthin. The recombinant polynucleotide sequence is designed to provide a higher level of astaxanthin precursors via a shorter metabolic pathway, and thereby attains higher level of end products (e.g., astaxanthin) with desired stereoisomeric form and/or esterified form.

公开(公告)号：EP2632944B1

公开(公告)日：2017-06-21

申请号：EP11836621.0

申请日：2011-10-26

申请人： Hanmi Science Co., Ltd.

发明人： CHOI, Sung Chul ,  KIM, Jin Ki ,  OH, Young Hak ,  LEE, Jong Soo

IPC分类号： C07K14/53 ,  C07K1/16 ,  C12N15/27 ,  C12N15/70

CPC分类号： C07K1/36 ,  C07K14/535

公开(公告)号：EP2552949B1

公开(公告)日：2016-08-17

申请号：EP11763394.1

申请日：2011-03-30

申请人： Pfenex Inc.

发明人： JIN, Hongfan ,  CHEW, Lawrence

IPC分类号： C07K14/535 ,  C12N15/27 ,  C12N15/78 ,  C12R1/39

CPC分类号： C07K14/535 ,  C07K2319/034 ,  C12P21/02

公开(公告)号：EP2345724B1

公开(公告)日：2013-07-03

申请号：EP10011853.8

申请日：1994-01-27

申请人： Amgen Inc.

发明人： Osslund, Timothy

IPC分类号： C07K14/535 ,  A61K38/19 ,  A61K47/48 ,  C12P21/02 ,  G06F19/10 ,  C12N15/27

CPC分类号： C07K1/00 ,  A61K38/00 ,  C07K14/535 ,  C07K2299/00 ,  C07K2319/00 ,  Y02A90/26

摘要： Provided herein are granulocyte colony stimulating factor ("G-CSF") analogs, compositions containing such analogs, and related compositions. In another aspect, provided herein are nucleic acids encoding the present analogs or related nucleic acids, related host cells and vectors. In yet another aspect, provided herein are computer programs and apparatuses for expressing the three dimensional structure of G-CSF and analogs thereof. In another aspect, provided herein are methods for rationally designing G-CSF analogs and related compositions. In yet another aspect, provided herein are methods for treatment using the present G-CSF analogs.

公开(公告)号：EP2479277A2

公开(公告)日：2012-07-25

申请号：EP12150386.6

申请日：2005-07-21

申请人： Five Prime Therapeutics, Inc.

发明人： Behrens, Dirk ,  Marshall, Shannon ,  Wong, Justin, G., P. ,  Wu, Ge ,  Zhou, Aileen ,  Leo, Cindy ,  Williams, Lewis, T. ,  Bosch, Elizabeth ,  Doberstein, Steven ,  Halenbeck, Robert, Forgan ,  Hestir, Kevin ,  Huang, Min, Mei ,  Lee, Ernestine ,  Lin, Haishan ,  Linnemann, Thomas

IPC分类号： C12N15/27 ,  C12N5/10 ,  C07K14/53 ,  C07K16/18 ,  C12Q1/68 ,  G01N33/68

CPC分类号： C07K16/243 ,  A61K38/00 ,  C07K14/53

摘要： The present invention relates to in vitro methods for stimulating, or increasing a population of, immune cells comprising using compositions which comprise a substantially pure polypeptide comprising a first amino acid sequence having at least about 70% homology to a sequence selected from SEQ. ID. NOs:7, 8, 9, and 11; or a biologically active fragment of any of these, wherein said polypeptide or fragment thereof can stimulate the proliferation and differentiation of granulocytes, monocytes, or dendritic cells; and to the use of these polypeptides in methods of treatment

摘要翻译： 本发明涉及用于刺激或增加免疫细胞群体的体外方法，其包括使用包含基本上纯的多肽的组合物，所述组合物包含与选自SEQ ID NO：1的序列具有至少约70％同源性的第一氨基酸序列。 ID。 NO：7,8,9和11; 或任何这些的生物活性片段，其中所述多肽或其片段可以刺激粒细胞，单核细胞或树突状细胞的增殖和分化; 以及这些多肽在治疗方法中的用途

公开(公告)号：EP1272633B1

公开(公告)日：2011-04-27

申请号：EP01920913.9

申请日：2001-03-30

申请人： DENDREON CORPORATION

发明人： LAUS, Reiner ,  VIDOVIC, Damir ,  GRADDIS, Thomas

IPC分类号： C12N15/12 ,  C12N15/27 ,  C12N15/55 ,  C12N15/62 ,  C12N9/16 ,  C12N5/07 ,  C07K14/535 ,  C07K14/71 ,  C07K19/00 ,  A61K39/00

CPC分类号： A61K39/0011 ,  A61K39/385 ,  A61K2039/5154 ,  A61K2039/5158 ,  A61K2039/55522 ,  A61K2039/6031 ,  C07K14/535 ,  C07K14/71 ,  C07K2319/00 ,  C07K2319/02 ,  C12N9/16

摘要： Disclosed are immunostimulatory fusion proteins and methods for generating protective DC-induced, T cell-mediated immune responses in vitro and in vivo. The immunostimulatory fusion proteins comprise a polypeptide antigen component and an immunostimulatory component derived from the intracellular domain of the HER-2 protein. Also disclosed are immunostimulatory compositions comprising dendritic cells pulsed with such an immunostimulatory fusion protein and methods for immunotherapy using the compositions.

公开(公告)号：EP2287310A1

公开(公告)日：2011-02-23

申请号：EP10179665.4

申请日：2005-07-21

申请人： Five Prime Therapeutics, Inc.

发明人： Behrens, Dirk ,  Bosch, Elizabeth ,  Doberstein, Steven ,  Halenbeck, Robert, Forgan ,  Hestir, Kevin ,  Huang, Min, Mei ,  Lee, Ernestine ,  Lin, Haishan ,  Linnemann, Thomas ,  Marshall, Shannon ,  Wong, Justin, G., P. ,  WU, Ge ,  Zhou, Aileen ,  Leo, Cindy ,  Williams, Lewis, T.

IPC分类号： C12N15/27 ,  C12N5/10 ,  C07K14/53 ,  C07K16/18 ,  C12Q1/68 ,  G01N33/68

CPC分类号： C07K16/243 ,  A61K38/00 ,  C07K14/53

摘要： The present invention relates to in vitro methods for stimulating, or increasing a population of, immune cells comprising using compositions which comprise a substantially pure polypeptide comprising a first amino acid sequence having at least about 70% homology to a sequence selected from SEQ. ID. NOs:7, 8, 9, and 11; or a biologically active fragment of any of these, wherein said polypeptide or fragment thereof can stimulate the proliferation and differentiation of granulocytes, monocytes, or dendritic cells; and to the use of these polypeptides in methods of treatment

摘要翻译： 本发明涉及用于刺激或增加免疫细胞群体的体外方法，其包括使用包含基本上纯的多肽的组合物，所述组合物包含与选自SEQ ID NO：1的序列具有至少约70％同源性的第一氨基酸序列。 ID。 NO：7,8,9和11; 或任何这些的生物活性片段，其中所述多肽或其片段可以刺激粒细胞，单核细胞或树突状细胞的增殖和分化; 以及这些多肽在治疗方法中的用途

公开(公告)号：EP1933857A2

公开(公告)日：2008-06-25

申请号：EP06814307.2

申请日：2006-09-07

申请人： Jennerex Biotherapeutics ULC

发明人： KIRN, David

IPC分类号： A61K35/76 ,  A61P35/00 ,  C12N15/27

CPC分类号： A61K35/768 ,  A01K67/0271 ,  A01K2207/20 ,  A01K2227/105 ,  A01K2267/0331 ,  A01K2267/0393 ,  A61K9/0019 ,  A61K38/00 ,  A61K49/0008 ,  A61K2039/54 ,  C07K14/535 ,  C12N7/00 ,  C12N15/86 ,  C12N2710/24111 ,  C12N2710/24132 ,  C12N2710/24143 ,  A61K2300/00

摘要： The present invention concerns methods and compositions for the treatment of cancer and cancer cells using intravascular administration of a vaccinia virus. In some embodiments, methods and compositions involve a replicative vaccinia virus that encodes GM-CSF.

公开(公告)号：EP1801204A1

公开(公告)日：2007-06-27

申请号：EP06026820.8

申请日：1995-08-09

申请人： Schering-Plough Ltd.

发明人： Wild, Martha ,  Junker, David E. ,  Cochran, Mark D. ,  Singer, Philip

IPC分类号： C12N5/10 ,  C12N5/20 ,  C12N7/01 ,  C12N15/00 ,  C12N15/09 ,  C12N15/12 ,  C12N15/19 ,  C12N15/24 ,  C12N15/26 ,  C12N15/27

CPC分类号： C12N15/86 ,  C12N2710/16334 ,  C12N2710/16343

摘要： This invention provides a recombinant herpesvirus of turkeys comprising a foreign DNA sequence encoding a cytokine inserted into an insertion region which comprises a Xhol site within an EcoR1 #9 fragment of a herpesvirus of turkeys viral genome, and the foreign DNA sequence encoding a cytokine which is capable of being expressed in a host cell infected with the herpesvirus of turkeys. This invention provides a recombinant herpesvirus of turkeys-Marek's disease virus chimera comprising a herpesvirus of turkeys unique long viral genome region and a Marek's disease virus unique short region. Lastly, this invention provides homology vectors for producing a recombinant herpesvirus of turkeys, host cells, and vaccines and methods for immunization.