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公开(公告)号：EP2287310B1
公开(公告)日：2015-05-06
申请号：EP10179665.4
申请日：2005-07-21
发明人： Behrens, Dirk , Bosch, Elizabeth , Doberstein, Steven , Halenbeck, Robert, Forgan , Hestir, Kevin , Huang, Min, Mei , Lee, Ernestine , Lin, Haishan , Linnemann, Thomas , Marshall, Shannon , Wong, Justin, G., P. , WU, Ge , Zhou, Aileen , Leo, Cindy , Williams, Lewis, T.
CPC分类号： C07K16/243 , A61K38/00 , C07K14/53
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公开(公告)号：EP2479277B1
公开(公告)日：2015-09-02
申请号：EP12150386.6
申请日：2005-07-21
发明人： Behrens, Dirk , Marshall, Shannon , Wong, Justin, G., P. , Wu, Ge , Zhou, Aileen , Leo, Cindy , Williams, Lewis, T. , Bosch, Elizabeth , Doberstein, Steven , Halenbeck, Robert, Forgan , Hestir, Kevin , Huang, Min, Mei , Lee, Ernestine , Lin, Haishan , Linnemann, Thomas
CPC分类号： C07K16/243 , A61K38/00 , C07K14/53
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公开(公告)号：EP2479277A3
公开(公告)日：2012-08-22
申请号：EP12150386.6
申请日：2005-07-21
发明人： Behrens, Dirk , Marshall, Shannon , Wong, Justin, G., P. , Wu, Ge , Zhou, Aileen , Leo, Cindy , Williams, Lewis, T. , Bosch, Elizabeth , Doberstein, Steven , Halenbeck, Robert, Forgan , Hestir, Kevin , Huang, Min, Mei , Lee, Ernestine , Lin, Haishan , Linnemann, Thomas
CPC分类号： C07K16/243 , A61K38/00 , C07K14/53
摘要： The present invention relates to in vitro methods for stimulating, or increasing a population of, immune cells comprising using compositions which comprise a substantially pure polypeptide comprising a first amino acid sequence having at least about 70% homology to a sequence selected from SEQ. ID. NOs:7, 8, 9, and 11; or a biologically active fragment of any of these, wherein said polypeptide or fragment thereof can stimulate the proliferation and differentiation of granulocytes, monocytes, or dendritic cells; and to the use of these polypeptides in methods of treatment
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4.发明公开Compositions and methods of use for MGD-CSF in disease treatment 有权Verwendung von MGD-CDF zur Behandlung der Alzheimer's Krankheit
公开(公告)号：EP2479277A2
公开(公告)日：2012-07-25
申请号：EP12150386.6
申请日：2005-07-21
发明人： Behrens, Dirk , Marshall, Shannon , Wong, Justin, G., P. , Wu, Ge , Zhou, Aileen , Leo, Cindy , Williams, Lewis, T. , Bosch, Elizabeth , Doberstein, Steven , Halenbeck, Robert, Forgan , Hestir, Kevin , Huang, Min, Mei , Lee, Ernestine , Lin, Haishan , Linnemann, Thomas
CPC分类号： C07K16/243 , A61K38/00 , C07K14/53
摘要： The present invention relates to in vitro methods for stimulating, or increasing a population of, immune cells comprising using compositions which comprise a substantially pure polypeptide comprising a first amino acid sequence having at least about 70% homology to a sequence selected from SEQ. ID. NOs:7, 8, 9, and 11; or a biologically active fragment of any of these, wherein said polypeptide or fragment thereof can stimulate the proliferation and differentiation of granulocytes, monocytes, or dendritic cells; and to the use of these polypeptides in methods of treatment
摘要翻译： 本发明涉及用于刺激或增加免疫细胞群体的体外方法，其包括使用包含基本上纯的多肽的组合物，所述组合物包含与选自SEQ ID NO：1的序列具有至少约70％同源性的第一氨基酸序列。 ID。 NO：7,8,9和11; 或任何这些的生物活性片段，其中所述多肽或其片段可以刺激粒细胞，单核细胞或树突状细胞的增殖和分化; 以及这些多肽在治疗方法中的用途
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5.发明公开Compositions and methods of use for mgd-csf in disease treatment 有权Zusammensetzungen und Verfahren zur Verwendung von MGD-CSF zur Krankheitsbehandlung
公开(公告)号：EP2287310A1
公开(公告)日：2011-02-23
申请号：EP10179665.4
申请日：2005-07-21
发明人： Behrens, Dirk , Bosch, Elizabeth , Doberstein, Steven , Halenbeck, Robert, Forgan , Hestir, Kevin , Huang, Min, Mei , Lee, Ernestine , Lin, Haishan , Linnemann, Thomas , Marshall, Shannon , Wong, Justin, G., P. , WU, Ge , Zhou, Aileen , Leo, Cindy , Williams, Lewis, T.
CPC分类号： C07K16/243 , A61K38/00 , C07K14/53
摘要： The present invention relates to in vitro methods for stimulating, or increasing a population of, immune cells comprising using compositions which comprise a substantially pure polypeptide comprising a first amino acid sequence having at least about 70% homology to a sequence selected from SEQ. ID. NOs:7, 8, 9, and 11; or a biologically active fragment of any of these, wherein said polypeptide or fragment thereof can stimulate the proliferation and differentiation of granulocytes, monocytes, or dendritic cells; and to the use of these polypeptides in methods of treatment
摘要翻译： 本发明涉及用于刺激或增加免疫细胞群体的体外方法，其包括使用包含基本上纯的多肽的组合物，所述组合物包含与选自SEQ ID NO：1的序列具有至少约70％同源性的第一氨基酸序列。 ID。 NO：7,8,9和11; 或任何这些的生物活性片段，其中所述多肽或其片段可以刺激粒细胞，单核细胞或树突状细胞的增殖和分化; 以及这些多肽在治疗方法中的用途
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