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1.发明授权MESSVERFAHREN UNTER EINSATZ MINDESTENS EINER BIOLOGISCHEN REZEPTORZELLE SOWIE EINE ZUR DURCHFÜHRUNG DES MESSVERFAHRENS GEEIGNETE VORRICHTUNG 有权测量方法使用至少一个生物受体细胞以及实施测量器件非常适合的一种方法
公开(公告)号：EP1255982B1
公开(公告)日：2005-11-09
申请号：EP00989805.7
申请日：2000-11-28
发明人： SCHÖNING, Michael, J. , LÜTH, Hans , KAUPP, Ulrich, B. , SCHÜTZ, Stefan , SCHROTH, Peter , THUST, Marion
IPC分类号： G01N27/414
CPC分类号： G01N33/5005 , G01N33/0031
摘要： The reactions of single cells to particular substances in their environment can be established by means of signal converters. In a manner known per se, the potential difference between the interior and the exterior of a cell is measured by means of electrodes, whereby the cell is, however, damaged at least in certain places. Conventional methods which permit a recording of a cell reaction without intervening in the cell interior are either complex or limited in response. In a measuring technique, using at least one biological receptor cell, an asymmetric, extra-cellular, electrical potential of the at least one receptor cell is formed, which produces a multi-pole field and said multi-pole field is applied to determining the cell reaction. The asymmetry in the extra-cellular electrical potential of the at least one receptor cell which reacts to environmental changes can be achieved by, for example, embedding the at least one receptor cell in a bedding element which corresponds to the geometrical form thereof.
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2.发明公开MESSVERFAHREN UNTER EINSATZ MINDESTENS EINER BIOLOGISCHEN REZEPTORZELLE SOWIE EINE ZUR DURCHFÜHRUNG DES MESSVERFAHRENS GEEIGNETE VORRICHTUNG 有权测量方法使用至少一个生物受体细胞以及实施测量器件非常适合的一种方法
公开(公告)号：EP1255982A2
公开(公告)日：2002-11-13
申请号：EP00989805.7
申请日：2000-11-28
发明人： SCHÖNING, Michael, J. , LÜTH, Hans , KAUPP, Ulrich, B. , SCHÜTZ, Stefan , SCHROTH, Peter , THUST, Marion
IPC分类号： G01N27/414
CPC分类号： G01N33/5005 , G01N33/0031
摘要： The reactions of single cells to particular substances in their environment can be established by means of signal converters. In a manner known per se, the potential difference between the interior and the exterior of a cell is measured by means of electrodes, whereby the cell is, however, damaged at least in certain places. Conventional methods which permit a recording of a cell reaction without intervening in the cell interior are either complex or limited in response. In a measuring technique, using at least one biological receptor cell, an asymmetric, extra-cellular, electrical potential of the at least one receptor cell is formed, which produces a multi-pole field and said multi-pole field is applied to determining the cell reaction. The asymmetry in the extra-cellular electrical potential of the at least one receptor cell which reacts to environmental changes can be achieved by, for example, embedding the at least one receptor cell in a bedding element which corresponds to the geometrical form thereof.
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3.发明公开MESSVORRICHTUNG MIT PROBENZELLE ZUM NACHWEIS VON KLEINEN PROBENMENGEN IN FLÜSSIGKEITEN 审中-公开测量与样品室设备技术液体的少量样品的检测
公开(公告)号：EP1029235A1
公开(公告)日：2000-08-23
申请号：EP98963337.5
申请日：1998-11-02
IPC分类号： G01N27/327 , C12Q1/00 , G01N27/22 , G01N27/414
CPC分类号： C12Q1/005 , G01N27/221
摘要： The present invention relates to a measuring device which comprises a sampling cell as well as an electrolyte contained in said cell, wherein said device is used for detecting the quantity of a sample using a sensor. The active side of the sensor is in direct contact with the amount of sample to be analysed, while a diffusion barrier, such as a polymeric film readily available on the market, is used for separating the sample from the electrolyte.
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