MESSVERFAHREN UNTER EINSATZ MINDESTENS EINER BIOLOGISCHEN REZEPTORZELLE SOWIE EINE ZUR DURCHFÜHRUNG DES MESSVERFAHRENS GEEIGNETE VORRICHTUNG
    3.
    发明授权
    MESSVERFAHREN UNTER EINSATZ MINDESTENS EINER BIOLOGISCHEN REZEPTORZELLE SOWIE EINE ZUR DURCHFÜHRUNG DES MESSVERFAHRENS GEEIGNETE VORRICHTUNG 有权
    测量方法使用至少一个生物受体细胞以及实施测量器件非常适合的一种方法

    公开(公告)号:EP1255982B1

    公开(公告)日:2005-11-09

    申请号:EP00989805.7

    申请日:2000-11-28

    IPC分类号: G01N27/414

    CPC分类号: G01N33/5005 G01N33/0031

    摘要: The reactions of single cells to particular substances in their environment can be established by means of signal converters. In a manner known per se, the potential difference between the interior and the exterior of a cell is measured by means of electrodes, whereby the cell is, however, damaged at least in certain places. Conventional methods which permit a recording of a cell reaction without intervening in the cell interior are either complex or limited in response. In a measuring technique, using at least one biological receptor cell, an asymmetric, extra-cellular, electrical potential of the at least one receptor cell is formed, which produces a multi-pole field and said multi-pole field is applied to determining the cell reaction. The asymmetry in the extra-cellular electrical potential of the at least one receptor cell which reacts to environmental changes can be achieved by, for example, embedding the at least one receptor cell in a bedding element which corresponds to the geometrical form thereof.