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    COMPOSITIONS AND METHODS FOR ENHANCED GENERATION OF HEMATOPOIETIC STEM/PROGENITOR CELLS
    2.
    发明公开
    COMPOSITIONS AND METHODS FOR ENHANCED GENERATION OF HEMATOPOIETIC STEM/PROGENITOR CELLS 审中-公开
    组合物和方法的造血干/祖细胞的增加的生产

    公开(公告)号：EP2788476A1

    公开(公告)日：2014-10-15

    申请号：EP12806795.6

    申请日：2012-12-07

    申请人： Fred Hutchinson Cancer Research Center ,  Novartis Institute For Functional Genomics, Inc. d/b/a The Genomics Institute of the Novartis Research Foundation (GNF)

    发明人： BERNSTEIN, Irwin, D. ,  BOITANO, Anthony, E. ,  COOKE, Michael

    IPC分类号： C12N5/0789 ,  A61K35/12

    CPC分类号： C12N5/0647 ,  A61K35/28 ,  A61K2035/124 ,  C12N2501/125 ,  C12N2501/145 ,  C12N2501/2303 ,  C12N2501/2306 ,  C12N2501/26 ,  C12N2501/38 ,  C12N2501/42 ,  C12N2501/60 ,  C12N2501/999

    摘要： The present invention relates to methods, kits and compositions for expansion of hematopoietic stem/progenitor cells and providing hematopoietic function to human patients in need thereof. In one aspect, it relates to kits and compositions comprising a Notch agonist and an aryl hydrocarbon receptor antagonist. Also provided herein are methods for expanding the hematopoietic stem/progenitor cells using kits and compositions comprising a Notch agonist and an aryl hydrocarbon receptor antagonist. The hematopoietic stem/progenitor cells expanded using the disclosed kits, compositions and methods include human umbilical cord blood stem/progenitor cells, placental cord blood stem/progenitor cells and peripheral blood stem cells. The present invention also relates to administering hematopoietic stem/progenitor cells expanded using a combination of a Notch agonist and an aryl hydrocarbon receptor antagonist to a patient for short-term and/or long-term in vivo repopulation benefits.

    摘要翻译： 本发明涉及一种方法，试剂盒和组合物的造血干/祖细胞和造血功能提供对人类患者需要其的膨胀。 在一个方面，它涉及试剂盒和组合物，包含一陷波激动剂芳香烃受体拮抗剂和。 所以提供了用于使用试剂盒扩大的造血干/祖细胞和组合物，其包括的Notch激动剂芳香烃受体拮抗剂和方法。 使用盘扩大了的造血干/祖细胞的试剂盒游离缺失，组合物和方法包括人脐血干/祖细胞，胎盘脐带血干细胞/祖细胞和外周血干细胞。 因此，本发明涉及管理使用的Notch激动剂和芳香烃受体拮抗剂的组合，以在体内再增殖好处短期和/或长期的患者扩增的造血干/祖细胞。